A kind of pharmaceutical composition for analgesia and preparation method thereof
A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of toxicity, no ventilator, addictive liver and kidney, etc., achieve small side effects, safe and convenient management , quick effect
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Examples
Embodiment 1
[0018] The preparation of embodiment 1 pearl lotus extract
[0019] Clean and dry 1 kg of pearl lotus dry product, pulverize it with a FW135 type traditional Chinese medicine pulverizer, place it in an extraction device with a round bottom flask, and successively use 95% (v / v) ethanol 8 L for reflux extraction for 2 hours, filter, Obtain the alcohol extract, repeat twice, combine the alcohol extract, concentrate to dryness under reduced pressure to obtain a crude extract, dissolve it into a suspension with 3L of pure water, and extract twice with 3L of ethyl acetate to obtain an ethyl acetate extract and water raffinate were concentrated under reduced pressure to form a thick paste, freeze-dried, pulverized into fine powder, and passed through a 100-mesh sieve to obtain the extract of ethyl acetate part and water part of Pearl Lotus.
Embodiment 2
[0020] Example 2 Study on the analgesic effect of pearl lotus extract on hot plate-induced pain
[0021] Take healthy female Kunming mice, place them on a hot plate (55±0.5)°C in turn, observe and record the time (s) from putting them on the hot plate to licking their hind paws, and set the time for licking their hind paws to 30s or Leapers are discarded. 40 female mice that passed the screening were selected, and the pain threshold was re-measured once after an interval of 5 minutes, and the average value of the data measured twice was used as the pain threshold before administration. According to the pain threshold before administration, it was randomly divided into the following four groups: blank control group (blank group), positive control group (positive group), pearl lotus ethyl acetate part extract group (ethyl ester group), pearl lotus water part extract group (water extraction group), 10 rats in each group. Based on the body weight of the mice, each group was give...
Embodiment 3
[0031] Example 3 Study on the inhibitory effect of pearl lotus extract on pain induced by acetic acid
[0032] Take 40 healthy Kunming mice and randomly divide them into the following four groups: blank control group (blank group), positive control group (positive group), pearl lotus ethyl acetate part extract group (ethyl ester group), pearl lotus water part In the extract group (water extraction group), each group was divided into male and female, with 10 rats in each group. Based on the body weight of the mice, each group was given the corresponding test substance in the following doses:
[0033] Blank group: normal saline 0.15mL / 10g;
[0034] Positive group: aspirin 0.2g / kg;
[0035] Ethyl group: 600 mg / kg of the dry powder of the extract of the part of the pearl lotus ethyl acetate prepared in Example 1;
[0036] Water extraction group: 600mg / kg of dry powder of pearl lotus water part extract prepared in Example 1;
[0037] Each group was intragastrically administered...
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Description
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Application Information
- IPC
- A61K36/71; A61P29/00; A61K125/00
- Inventors
- 赵明强; 焦晨