Therapeutic immunization in hiv infected subjects receiving stable antiretroviral treatment

An anti-retroviral, treatment plan technology, applied in the direction of retro RNA virus, antiviral agent, virus, etc., can solve the problem of no HIV vaccine clinical access qualification

Inactive Publication Date: 2014-12-10
VACCINE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, no HIV vaccine has been clinically approved

Method used

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  • Therapeutic immunization in hiv infected subjects receiving stable antiretroviral treatment
  • Therapeutic immunization in hiv infected subjects receiving stable antiretroviral treatment
  • Therapeutic immunization in hiv infected subjects receiving stable antiretroviral treatment

Examples

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Embodiment approach

[0310] 1. The application of a pharmaceutical composition, the pharmaceutical composition comprises a pharmaceutically acceptable carrier and an antigen preparation, the antigen preparation comprises HIV polypeptide or a fragment thereof, and the antigen preparation also comprises Bacillus anthracis lethal factor (LFn) At least residues 34-288 of the N-terminus of the polypeptide to enhance the therapeutic effect of HIV antiretroviral therapy in patients.

[0311] 2. The use of the composition of paragraph 1, wherein the HIV polypeptide or fragment thereof is fused to a LFn polypeptide.

[0312] 3. The use of the composition of paragraph 1 or 2, wherein the composition is administered to a patient in combination with conventional antiretroviral therapy.

[0313] 4. The use of the composition of any of paragraphs 1 to 3, wherein the composition is administered to a patient periodically.

[0314] 5. The use of the composition of any of paragraphs 1 to 4, wherein the composition...

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Abstract

The present invention generally relates to HIV compositions and methods of use. One aspect of the present invention relates to a composition comprising a pharmaceutically acceptable carrier and an antigen preparation, the antigen preparation comprising an HIV polypeptide or fragment thereof and a Bacillus anthracis lethal factor (LF) polypeptide, such as a LFn polypeptide. In some embodiments, the LF polypeptide can be fused or otherwise associated with the HIV polypeptide. Other aspect of the present invention relate to use of vaccine comprising a HIV polypeptide and a Bacillus anthracis lethal factor (LF) polypeptide in methods to enhance efficacy traditional antiretroviral therapy.

Description

technical field [0001] The present invention relates to compositions and methods for vaccination against the HIV (AIDS virus) virus. Specifically, the present invention delivers exogenous HIV viral proteins to the cytosol of cells. The invention also relates to methods used in conjunction with conventional retroviral therapy to facilitate retroviral therapy. [0002] Cross References to Related Applications [0003] This application claims the benefit of US Provisional Patent Application No. 61 / 353,176, filed June 9, 2010, which is incorporated herein by reference. Background technique [0004] About 25 million people living with HIV live in sub-Saharan Africa. In resource-poor settings, restrictive treatment options and the cost of alternative treatment options may expand the limits of antiretroviral treatment (ART) programs 1 . Uganda's current HIV infection rate of 6-10% remains unacceptably high. Most ART regimens available in Uganda are limited to low-cost and fix...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/21A61K39/07A61P31/18
CPCA61K39/07A61K2039/6037A61K39/21C12N2740/16234A61K2039/55505C07K2319/55A61K2039/572A61K39/12A61P31/18A61K2300/00
Inventor 卢毅辰曹玄
Owner VACCINE TECH
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