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Use of hericium erinaceus hyphae extract in preparation of drug for resisting stomach cancer

A technology of mycelium and Hericium erinaceus, which is applied in the directions of anti-tumor drugs, drug combinations, medical raw materials derived from fungi, etc., can solve the problems of anti-stomach cancer of the extract of Hericium erinaceus mycelium which has not been seen.

Inactive Publication Date: 2014-12-24
HUNAN XINHUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report that the extract of Hericium erinaceus mycelium is used for anti-gastric cancer

Method used

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  • Use of hericium erinaceus hyphae extract in preparation of drug for resisting stomach cancer
  • Use of hericium erinaceus hyphae extract in preparation of drug for resisting stomach cancer
  • Use of hericium erinaceus hyphae extract in preparation of drug for resisting stomach cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A Hericium erinaceus mycelium extract, its preparation method comprises the steps:

[0030] (1) Take the mycelium of Hericium erinaceus, perform the first water normal temperature flash extraction for 20 minutes, then perform the second water normal temperature flash extraction for 15 minutes; in the first water normal temperature flash extraction, The weight of water is 5 times of Hericium erinaceus mycelium weight; In the second water normal temperature flash extraction, the weight of water is 3 times of Hericium erinaceus mycelium weight;

[0031] (2) The supernatant obtained after centrifuging the extracts obtained after the above two extractions was concentrated under reduced pressure at 60°C until precipitation precipitated to obtain a concentrate; the concentrate was vacuum freeze-dried at -60°C, that is Hericium erinaceus mycelium extract.

[0032] Wherein, the temperature of flash extraction at normal temperature of water is 30°C. The conditions for centrifug...

Embodiment 2

[0034] A Hericium erinaceus mycelium extract, its preparation method comprises the steps:

[0035] (1) Take the mycelium of Hericium erinaceus, perform the first water normal temperature flash extraction for 20 minutes, then perform the second water normal temperature flash extraction for 15 minutes; in the first water normal temperature flash extraction, The weight of water is 5 times of Hericium erinaceus mycelium weight; In the second water normal temperature flash extraction, the weight of water is 3 times of Hericium erinaceus mycelium weight;

[0036] (2) The supernatant obtained after centrifuging the extract obtained after the above two extractions was concentrated under reduced pressure at 60°C until precipitation was precipitated to obtain a concentrate;

[0037] (3) Dissolve the concentrated solution in step (2) with ethanol whose weight is 5 times the weight of the concentrated solution and whose volume percentage concentration is 80%, concentrate the dissolved par...

Embodiment 3

[0040] A Hericium erinaceus mycelium extract, its preparation method comprises the steps:

[0041] (1) Take the mycelium of Hericium erinaceus, perform the first water normal temperature flash extraction for 20 minutes, then perform the second water normal temperature flash extraction for 15 minutes; in the first water normal temperature flash extraction, The weight of water is 5 times of Hericium erinaceus mycelium weight; In the second water normal temperature flash extraction, the weight of water is 3 times of Hericium erinaceus mycelium weight;

[0042] (2) The supernatant obtained after centrifuging the extract obtained after the above two extractions was concentrated under reduced pressure at 60°C until precipitation was precipitated to obtain a concentrate;

[0043] (3) Dissolve the concentrated solution in step (2) with ethanol whose weight is 5 times the weight of the concentrated solution and whose volume percentage concentration is 80%, and vacuum freeze-dry the ins...

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PUM

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Abstract

The invention discloses a use of hericium erinaceus hyphae extract in preparation of a drug for resisting stomach cancer. Hericium erinaceus hyphae is subjected to two-step normal-temperature flash extraction, the extract is subjected to pressure reduction concentration, and the concentrate is subjected to vacuum freeze drying to form the hericium erinaceus hyphae extract. The hericium erinaceus hyphae extract has stomach cancer-resistant effects and can be used for preparation a drug for resisting stomach cancer.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and in particular relates to the application of Hericium erinaceus mycelium extract in the preparation of anti-gastric cancer drugs. Background technique [0002] Gastrointestinal cancer such as liver cancer, stomach cancer, colon cancer, and rectal cancer is one of the most common cancers, accounting for about 25% of all cancers according to the American Cancer Society. The incidence of gastric cancer ranks fourth among cancers in the world. China has a high incidence and mortality rate (50% of the deaths occur in China). The treatment of gastrointestinal cancer includes surgery, chemical drug therapy, and radiotherapy and immunotherapy. Chemotherapy is the most commonly used method although it cannot be completely cured. In the past few decades, the development of molecular biology has made some progress in the treatment of gastric cancer, but drug resistance and toxicity still lim...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/06A61P35/00
Inventor 何述金常耀台曹寿松
Owner HUNAN XINHUI PHARMA