A kind of dulcitol sulfate potassium or dulcitol sulfate sodium and its preparation method and application

A technology of dulcitol and sulfuric acid ester, applied in the field of preparation, can solve not many problems, achieve the effect of improving hyperlipidemia, improving hyperlipidemia and hypoalbuminemia, and reducing urinary protein

Inactive Publication Date: 2017-04-19
天津中津药业股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are not many studies on synthesizing biologically active derivatives using dulcitol as a raw material, so it is necessary to provide a method for synthesizing biologically active derivatives using dulcitol as a raw material

Method used

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  • A kind of dulcitol sulfate potassium or dulcitol sulfate sodium and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Take 1000 grams of dry dulcitol, put it in a sulfonation kettle, add 35 liters of formamide, stir evenly, pass through the outside of the sulfonation kettle, put ice salt water to cool down, add 4 liters of chlorosulfonic acid dropwise while stirring, During the process of adding chlorosulfonic acid, keep the temperature in the sulfonation tank at 1-5°C. After the dropwise addition of chlorosulfonic acid is completed, the reactant is heated to 65°C for reaction; after the reaction is completed, add ethanol so that the concentration of ethanol is 75% by weight, make it generate dulcitol sulfate precipitation; Wash the dulcitol sulfate precipitation 3 times with the ethanol of 75% by weight concentration; With the sodium hydroxide solution of 10% by weight concentration, adjust pH to 7.5, Generate dulcitol sulfate sodium solution; The dulcitol sulfate sodium solution that will be formed is refined through anion and cation exchange columns respectively, and then the potassi...

Embodiment 2

[0047] Example 2 Clinical Trials

[0048] 30 subjects took dulcitol sulfate sodium orally, 0.15g each time, three times a day, and there were no adverse reactions after taking the medicine, and all had different degrees of curative effect on patients with chronic renal failure.

[0049] Case 1 male, aged 70 years, suffering from uremia. Long-term hospitalization took dulcitol sulfate sodium for one month, plasma urea nitrogen decreased from 11.3mmol / L to 6.8mmol / L, plasma cholesterol decreased from 5.5mmol / L to 4.8mmol / L, and creatinine decreased from 600μmol / L to 220μmol / L.

[0050] Case 2 male, aged 57 years, with uremia. After taking dulcitol sulfate sodium for two months, plasma urea nitrogen decreased from 10.2mmol / L to 6.6mmol / L, plasma cholesterol decreased from 5.4mmol / L to 4.8mmol / L, and creatinine decreased from 1000μmol / L to 220μmol / L, the triglyceride 1.35mmol / L dropped to 0.75mmol / L.

[0051] Case 3 female, aged 66 years, suffering from uremia. After taking ...

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Abstract

The invention discloses dulcitol potassium sulfate ester or dulcitol sodium sulfate ester. The dulcitol potassium sulfate ester or dulcitol sodium sulfate ester is prepared according to the steps of firstly generating dulcitol sulfate ester by reacting dulcitol as the raw material and formamide and chlorosulfonic acid which are added inside, and then carrying out neutralization by adding potassium hydroxide or a potassium hydroxide solution to generate dulcitol potassium sulfate ester or dulcitol sodium sulfate ester. The dulcitol potassium sulfate ester or dulcitol sodium sulfate ester has the function of treating chronic renal failure.

Description

[0001] 【Technical field】 [0002] The invention relates to a preparation method, in particular to a preparation method of dulcitol sulfate potassium or dulcitol sulfate sodium. [0003] 【Background technique】 [0004] Dulcitol, also known as sweet alcohol, galactitol, hexyl alcohol. The structural formula is HOCH 2 (CHOH) 4 CH 2 Oh, Molecular weight: 182.18, it is a colorless monoclinic columnar crystal. The taste is slightly sweet. Slightly soluble in alcohol and ether; pH 4-7 when soluble in water, especially easily soluble in boiling water. Colorless crystalline powder. The taste is slightly sweet. 1g is dissolved in 2ml boiling water, 30ml cold water, slightly soluble in ethanol. Relative density (d20) 1.47. The melting point is 188-189°C. The boiling point is 275-280°C (0.13kPa). Dulcitol has been clinically used to treat rheumatoid for many years, and it has a certain effect. However, there are not many studies on the synthesis of biologically active derivat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/255A61P13/12
Inventor 宋富智梁世昌宋德顺
Owner 天津中津药业股份有限公司
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