Non-human animal models of depression and methods of use thereof

A technology for depression, rodents, biochemical devices and methods, diagnostics using light, applications, etc., capable of addressing adverse side effects, depression, suicide, etc.

Inactive Publication Date: 2015-01-07
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Major depressive disorder is characterized by low mood, suicidal thoughts, job burnout, and an inability to experience happiness
Despite the prevalence of this debil

Method used

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  • Non-human animal models of depression and methods of use thereof
  • Non-human animal models of depression and methods of use thereof
  • Non-human animal models of depression and methods of use thereof

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Embodiment Construction

[0033] The present disclosure provides a non-human optogenetic animal model of depression. The animal model is useful for identifying agents to treat depression and identifying targets for therapeutic strategies to treat depression.

[0034] Nonhuman Animal Models of Depression

[0035] The present disclosure provides non-human animals that express light-responsive opsins (eg, light-responsive ion channels, light-responsive ion pumps, etc.) in animal neurons. Activation of the light-responsive opsin by exposing the light-activated opsin to light modulates animal behavior. In specific embodiments, photoactivation of a light-responsive opsin induces depression in the animal. In other embodiments, photoactivation of a light-responsive opsin alleviates depression.

[0036]In some instances, a subject non-human animal model of depression exhibits symptoms of depression in the presence of light that activates a light-responsive opsin. In other cases, the subject non-human animal...

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Abstract

The disclosure provides non-human optogenetic animal models of depression. Specifically, non-human animals each expresses a light- responsive opsin in a neuron of the animal are provided. The animal models are useful for identifying agents and targets of therapeutic strategies for treatment of depression. Examples of using the non-human animals expressing light-responsive opsin including Halorhodopsin family of light-responsive chloride pumps and Channelrhodopsin family of light-responsive cation channel proteins are described.

Description

[0001] Related applications [0002] This application claims the benefit of US Provisional Patent Application No. 61 / 613,231, filed March 20, 2012, which is hereby incorporated by reference in its entirety. Background of the invention [0003] Major depressive disorder is characterized by depressed mood, suicidal thoughts, job burnout, and an inability to experience happiness. Despite the prevalence of this debilitating mental illness, the most commonly used therapeutic intervention, selective serotonin reuptake inhibitors, is often ineffective and has severe adverse side effects. [0004] Current nonhuman animal models of depression are nonspecific. There is a need in the art for improved non-human animal models of depression. Summary of the invention [0005] The present disclosure provides a non-human optogenetic animal model of depression. The animal model is useful for identifying agents to treat depression and identifying targets for therapeutic strategies to treat ...

Claims

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Application Information

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IPC IPC(8): A01K67/027A61N1/30A61N5/06
CPCA61B5/0059A61B5/4076A01K67/027A61N5/06A61B5/04001A61B5/24A61B5/165A61B5/4848A01K2227/105A01K2267/0356A01K2267/0393C12N2750/14143C12N2800/30C12N2830/48A01K67/0275A01K2267/0306A61K49/0008C12N15/8509C12N2015/8536
Inventor K·A·戴瑟罗斯K·M·泰M·R·瓦登
Owner THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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