A chromatographic column or protective column ultrasonic cleaning device

Abstract

The invention belongs to the field of liquid chromatography analysis instruments, and specifically relates to an ultrasonic cleaning device for a chromatographic column or a guard column, which includes an energy supply device (1), a heat dissipation device (4), and a lower liquid flow pipe (8) at the bottom The sleeve (5) and the sleeve cover (7) with the upper liquid flow pipe (9) on the top; the lower end of the energy supply device (1) is an ultrasonic transducer (2), and the energy supply device (1) The upper end of the concentrator (3) is the energy concentrator (3), and the energy concentrator (3) is drawn toward the longitudinal center line from bottom to top; the top of the energy concentrator (3) is fixedly connected with the casing (5); the casing (5) has a hollow Cavity, the size of the cavity matches the size of the chromatographic column or guard column; the sleeve cover (7) is sealed with the sleeve (5); the heat dissipation device (4) is arranged on the outer wall of the energy concentrator (3) superior. The device uses the cleaning solution flowing through the chromatographic column to clean, does not need to be disassembled and washed, is convenient to use, and prevents the chromatographic column from being blocked.

Description

technical field [0001] The invention belongs to the field of liquid chromatography analysis instruments, and in particular relates to an ultrasonic cleaning device for a chromatographic column or a protective column. Background technique [0002] The chromatographic column is the core component in liquid chromatography analysis. There are permeable sieve plates and fillers inside the chromatographic column, and the guard column is usually shorter than the chromatographic column, and there are also permeable sieve plates and fillers inside, which are added to the chromatographic column as replaceable parts. before use. [0003] When liquid chromatography is working, the mobile phase and sample pass through the chromatographic column, so the insoluble substances in the sample and mobile phase are easy to block the sieve plate and packing of the chromatographic column, resulting in a rise in pressure, which seriously causes the instrument to fail to work or the chromatographic ...

AI Technical Summary

Problems solved by technology

[0003] When liquid chromatography is working, the mobile phase and sample pass through the chromatographic column, so the insoluble substances in the sample and mobile phase are easy to block the sieve plate and packing of the chromatographic column, resulting in a rise in pressure, which seriously causes the instrument to fail to work or the chromatographic column to be damaged

After the chromatographic column or pre-column is blocked, the existing cleaning method usually requires disassembling the chromatographic column connector, taking out the sieve plate or other parts and placing them in an ultrasonic cleaner for cleaning; The risk of loosening of the internal packing structure may cause the chromatographic column to be unusable in severe cases. In addition, the power density of the ultrasonic cleaner is small, so the cleaning time is long, and this cleaning method must disassemble the chromatographic column, which cannot realize the work of the chromatographic column online cleaning

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