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Butylphthalide preparation composite, preparation method therefor, and application thereof

A composition, the technology of butylphthalide, applied in the field of medicine

Active Publication Date: 2015-01-28
SHIJIAZHUANG PHARMA GRP NBP PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] In view of the above, there is a lack of a pharmaceutical composition in which butylphthalide and ligustilide are used in combination in the prior art, which can not only fully exert the effects of these two compounds, but also have stable quality

Method used

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  • Butylphthalide preparation composite, preparation method therefor, and application thereof
  • Butylphthalide preparation composite, preparation method therefor, and application thereof
  • Butylphthalide preparation composite, preparation method therefor, and application thereof

Examples

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Effect test

Embodiment 1

[0055] Embodiment 1: Butylphthalide composition soft capsule

[0056] 1) Prescription composition (1000 capsules):

[0057] Liquid composition: butylphthalide 100g, ligustilide 100g;

[0058] Capsule composition: the same as Comparative Example 1

[0059] 2) Preparation method:

[0060] A, the preparation of capsule skin solution: with comparative example 1;

[0061] b. Preparation of medicinal liquid: mix and dissolve each component of the medicinal liquid, and set aside;

[0062] c. Pressed soft capsules: press the soft capsules with the above liquid medicine and capsule skin solution, dry, pack, and each capsule contains 100 mg of butylphthalide and 100 mg of ligustilide.

Embodiment 2

[0063] Embodiment 2: Butylphthalide composition soft capsule

[0064] 1) Prescription composition (1000 capsules):

[0065] Liquid composition: butylphthalide 100g, ligustilide 20g;

[0066] Capsule composition: the same as Comparative Example 1

[0067] 2) Preparation method: same as Example 1.

Embodiment 3

[0068] Embodiment 3: Butylphthalide composition soft capsule

[0069] 1) Prescription composition (1000 capsules):

[0070] Liquid composition: butylphthalide 20g, ligustilide 100g;

[0071] Capsule composition: the same as Comparative Example 1

[0072] 2) Preparation method: same as Example 1.

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Abstract

The invention discloses a butylphthalide preparation composite and a preparation method therefor. The butylphthalide preparation composite comprises butylphthalide and ligustilide; accessories that are pharmaceutically acceptable can be further added into the pharmaceutical composite, so as to prepare soft capsules, liquid hard capsules, pills, dropping pills, etc.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a butylphthalide preparation composition and a preparation method thereof, in particular to a pharmaceutical composition of butylphthalide and ligustilide, a preparation method and an application thereof. Background technique [0002] Butylphthalide (3-n-butylpthhalide, NBP for short), full name 3-butyl-1(H)-isobenzofuranone, also known as apigenin A, is a racemate extracted from celery seed , can also be artificially synthesized. Butylphthalide is an oily liquid that is insoluble in water and has a strong celery smell. The molecule contains a chiral carbon atom, so it exists in two optical isomers, namely, L-butylphthalide (l-3-n- butylphthalide) and d-3-n-butylphthalide. Its molecular formula is as follows [0003] . [0004] Butylphthalide can reduce the infarction after focal cerebral ischemia, increase the cerebral blood flow in the ischemic area and improve the microci...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P9/10
CPCA61K31/365
Inventor 牛锋齐军彩焦魁良韩春景杨蕾
Owner SHIJIAZHUANG PHARMA GRP NBP PHARMA CO LTD
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