Preparation method of anti Helicobacter pylori active antibacterial peptide gastric mucosa nanoparticle delivery system

Abstract

A preparation method of an anti Helicobacter pylori active antibacterial peptide gastric mucosa nanoparticle delivery system. Helicobacter pylori is highly sensitive to the antibacterial peptide and does not generate resistance to the antibacterial peptide, and the antibacterial peptide nanoparticles have short acting time on Helicobacter pylori. Compared with an antibacterial peptide suspension, the antibacterial peptide nanoparticles stay a long time in the gastric mucosa, are not easy to be damaged by gastric acid and protease, and have very strong gastric mucous layer permeability to increase the concentration of antimicrobial peptides in the gastric mucosa, and are conducive to inhibit and kill planting Helicobacter pylori in the gastric mucosa. The antibacterial peptide nanoparticles have the function of eliminating Helicobacter pylori infection under lower amount of drug. The invention provides a novel approach and dosage form for the treatment of Helicobacter pylori.

Description

technical field [0001] The invention belongs to the field of biopharmaceuticals. An artificially synthesized anti-Helicobacter pylori active antimicrobial peptide Pexiganan nanoparticle gastric mucosa drug delivery system is made of two materials, chitosan and sodium alginate, and has the treatment of completely eradicating Helicobacter pylori infection. effect. Background technique [0002] Medical research has confirmed that 95% of stomach problems are caused by Helicobacter pylori infection. Helicobacter pylori infection leads to high incidence of gastritis, gastric ulcer, duodenal ulcer and gastric cancer, and the World Health Organization has listed it as a class I carcinogen. Despite the combined use of multiple antibiotics, there is currently no cure for Helicobacter pylori infection. Helicobacter pylori is resistant to many antibiotics, and the failure of its treatment has become a major medical problem. The mechanism of action of antimicrobial peptides is differe...

AI Technical Summary

Problems solved by technology

This system better solves the problem of drug adhesion and retention in the gastric mucosa, and also has the advantage of protecting acid-sensitive drugs from acid degradation, but these systems cannot assist antibacterial drugs to completely eradicate Helicobacter pylori

[0005] Helicobacter pylori has the ability to use flagella to penetrate the mucus layer and adhere to the surface of epidermal cells under the mucus layer of the mucous membrane. It colonizes in the acidic environment of the gastric mucosa. Although the adhesion and slow-release particles increase the residence time of the drug, the antibacterial drug cannot pass through it. Thick elastic gelatinous mucus layer of gastric mucosa

The use of bulking agents prevents the drug from staying in the gastric mucosa, and strong adhesives reduce the fluidity of the mucosa and interfere with the penetration of the drug into the deep mucosa

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