New flavone compound as well as preparation method and application thereof

A technology of flavonoids and compounds, applied in the field of new compounds, can solve the problems of limited types of flavonoids, etc., and achieve the effects of excellent whitening and anti-inflammatory effects, unique effects and novel structures

Active Publication Date: 2015-02-25
完美(广东)日用品有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] It can be seen that the various flavonoids isolated from Lychee Grass usually show good pharmaceutical activity, but the types of flavonoids isolated from Lychee Grass are very limited in the prior art

Method used

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  • New flavone compound as well as preparation method and application thereof
  • New flavone compound as well as preparation method and application thereof
  • New flavone compound as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The preparation method of flavonoid novel compound Ia described in the present embodiment comprises the steps:

[0041] (1) Weigh 10 parts by weight of the whole herb of Litchi, crush it and add 50 parts by weight of an aqueous solution of 95v% ethanol, stir well, soak for 30 days, collect the percolate, and concentrate in vacuum to obtain the extract of Litchi;

[0042] (2) The lychee grass extract is mixed with silica gel and diatomaceous earth with a mass ratio of 1:1, and loaded onto a silica gel column, using 3 times the column volume of petroleum ether and 3 times the column volume of acetic acid Ethyl is eluted as an eluent, and the ethyl acetate eluate is collected and concentrated to obtain 0.21 parts by weight of the first medicinal extract;

[0043] (3) Carry out silica gel column chromatography separation to the first medicinal extract, successively use 10 times of column volume of dichloromethane, 10 times of column volume of the mixed solvent of dichlorome...

Embodiment 2

[0056] The preparation method of flavonoid novel compound Ia described in the present embodiment comprises the steps:

[0057] (1) Weigh 10 parts by weight of the whole herb of Lychee Grass, add 300 parts by weight of 50v% ethanol aqueous solution after crushing, stir well, soak for 17.5 days, collect the percolate, and concentrate in vacuum to obtain the Lychee Grass extract;

[0058] (2) The lychee grass extract is mixed with silica gel and diatomaceous earth with a mass ratio of 3:1, and loaded onto a silica gel column, using petroleum ether of 10 times column volume and acetic acid of 10 times column volume successively Ethyl is eluted as an eluent, and the ethyl acetate eluate is collected and concentrated to obtain 0.26 parts by weight of the first medicinal extract;

[0059] (3) Carry out silica gel column chromatography separation to the first medicinal extract, use 3 times of column volumes of dichloromethane, 3 times of column volumes of the mixed solvent of dichloro...

Embodiment 3

[0063] The preparation method of flavonoid novel compound Ia described in the present embodiment comprises the steps:

[0064] (1) Weigh 10 parts by weight of the whole herb of Lychee Herb, add 200 parts by weight of absolute ethanol after crushing, stir well, soak for 18 days, collect the percolation liquid, and concentrate in vacuum to obtain the Herba Lychee extract;

[0065] (2) The lychee grass extract is mixed with silica gel and diatomaceous earth with a mass ratio of 1:1, and loaded onto a silica gel column, using 10 times the column volume of petroleum ether and 7 times the column volume of acetic acid Ethyl is eluted as an eluent, and the ethyl acetate eluate is collected and concentrated to obtain 0.25 parts by weight of the first medicinal extract;

[0066] (3) Carry out silica gel column chromatography separation to the first medicinal extract, use 3 times of column volumes of dichloromethane, 6 times of column volumes of the mixed solvent of dichloromethane and m...

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PUM

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Abstract

The invention provides a new flavone compound with a structure shown by a formula (I) in the specification, a preparation method thereof and an application thereof in skin whitening and/or anti-inflammation. The new flavone compound can significantly inhibit tyrosinase activity and the nitrogen oxide metabolism of LPS induced mice macrophage RAW 264.7, therefore, the new flavone compound provided by the invention can be hopefully used for preparing medicaments with skin whitening and anti-inflammation effects, and a new thought is provided for researching and developing medicaments, health products, daily chemical products and the like with skin whitening and anti-inflammation effects.

Description

technical field [0001] The present invention relates to a new compound in medicinal plants, in particular to a new flavonoid compound and its derivatives isolated from Lychee Grass, and to a preparation method of the new flavonoid compound and its derivatives and its application in whitening and / or anti-inflammatory applications. technical background [0002] Lychee grass is the whole herb of Salvia plebeian R.Br. in the family Labiatae. etc., are widely distributed in East China, South Central, and Southwest China, and are mainly produced in Jiangsu, Zhejiang, Anhui and other provinces. [0003] Litchi grass tastes bitter, pungent, and cool in nature. It has the functions of clearing heat and detoxifying, cooling blood and dissipating blood stasis, diuresis and reducing swelling. It is used to treat acute tonsillitis, chronic bronchitis, nephritis edema, hemorrhoid swelling and pain. The main chemical components in Lychee Grass include flavonoids, terpenes, sesquiterpenes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/04A61K31/352A61K8/49A61P29/00A61Q19/02
CPCA61K8/498A61Q19/02C07D493/04
Inventor 胡瑞连李子安段朝辉周秋娜侴桂新金敏蓉
Owner 完美(广东)日用品有限公司
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