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Preparation method of spectinomycin hydrochloride injection for dysentery

A spectinomycin hydrochloride and injection technology, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, non-central analgesics, etc., can solve the problems of ignoring the recovery of intestinal nerve function, tissue function, anti-inflammatory and fever reduction, etc. To prevent dehydration

Active Publication Date: 2017-04-05
CHONGQING ZONGYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Spectinomycin preparations for veterinary use currently on the market are only antibacterial, while ignoring the restoration of intestinal nerve function, tissue function, anti-inflammatory and fever reduction, and only treat the symptoms but not the root cause

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Prepare Spectinomycin Hydrochloride Injection for Diarrhea Spectinomycin Hydrochloride according to the following steps:

[0020] 1) Dissolve 45 million units of spectinomycin hydrochloride with water for injection, add 80 ml of propylene glycol, stir to dissolve, and set aside;

[0021] 2) Add 35 grams of sodium salicylate and 1 gram of EDTA-2Na to water for injection, stir to dissolve, and clarify for use;

[0022] 3) Mix the liquids obtained in steps 1) and 2), add 4 grams of belladonna extract, dilute to 1000 ml with water for injection, adjust the pH value to about 5.0 with glacial acetic acid, and sterile filter the solution for potting to obtain .

Embodiment 2

[0024] Prepare Spectinomycin Hydrochloride Injection for Diarrhea Spectinomycin Hydrochloride according to the following steps:

[0025] 1) Dissolve 50 million units of spectinomycin hydrochloride with water for injection, add 100 ml of propylene glycol, stir to dissolve, and set aside;

[0026] 2) Add 40 grams of sodium salicylate and 2 grams of EDTA-2Na to water for injection, stir to dissolve, and clarify for use;

[0027] 3) Mix the liquids obtained in steps 1) and 2), add 5 grams of belladonna extract, dilute to 1000 ml with water for injection, adjust the pH value to about 5.0 with glacial acetic acid, send liquid through sterile filtration, and seal, to obtain .

Embodiment 3

[0029] Prepare Spectinomycin Hydrochloride Injection for Diarrhea Spectinomycin Hydrochloride according to the following steps:

[0030] 1) Dissolve 55 million units of spectinomycin hydrochloride with water for injection, add 120 ml of propylene glycol, stir to dissolve, and set aside;

[0031] 2) Add 45 grams of sodium salicylate and 3 grams of EDTA-2Na into the water for injection, stir to dissolve, clarify and set aside;

[0032] 3) Mix the liquids obtained in steps 1) and 2), add 6 grams of belladonna extract, add water for injection to make the volume to 1000ml, adjust the pH value to about 5.0 with glacial acetic acid, and aseptically filter and send the liquid for potting, that is have to.

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Abstract

The invention provides a preparation method for a spectinomycin hydrochloride injection for curing diarrhea. The preparation method comprises the following steps: 1) dissolving spectinomycin hydrochloride with water for injection, adding propylene glycol, and performing stirring to dissolve for later use; 2) adding natrium salicylicum and EDTA-2Na into water for injection, stirring to dissolve, and clarifying for later use; 3) mixing liquids obtained in steps 1 and 2, adding a belladonna extract, setting the volume, adjusting the PH value, filtering in a sterile condition, and conveying the liquid to a liquid pot to be packed in a sealing manner to obtain the spectinomycin hydrochloride injection. 1000 ml of spectinomycin hydrochloride injection comprises 4500-5500 million units of spectinomycin hydrochloride, 35-45 g of natrium salicylicum, 4-6 g of belladonna extract, 80-120 ml of propylene glycol and 1-3 g of disodium EDTA (EDTA-2Na), and is set to 1000 ml in volume with water for injection. The traditional Chinese medicine belladonna extract is added into the spectinomycin hydrochloride injection prepared by the method provided by the invention, a new theory for treating livestock and poultry enteritis diarrhea is provided, and the spectinomycin hydrochloride injection can treat both symptoms and root causes of the diarrhea by combining Chinese traditional with western medicine.

Description

technical field [0001] The invention belongs to the field of veterinary medicine and relates to a preparation method of Spectinomycin Hydrochloride Injection with special effects for dysentery. Background technique [0002] Spectinomycin is an aminoglycoside antibiotic produced by Streptomyces, used for Gram-negative bacteria and mycoplasma infections. Spectinomycin has the advantages of low toxicity and less toxic and side effects on mammalian liver, lung, kidney, etc. within the effective dose range, and is becoming one of the preferred varieties of veterinary drugs. Studies have shown that Spectinomycin can effectively treat and prevent livestock and poultry diseases caused by Streptococcus, Erysipelas, Staphylococcus aureus, Pasteurella, Escherichia coli, Salmonella and Mycoplasma, especially for the mixed infection of Mycoplasma and Escherichia coli significantly. As a new veterinary antibiotic, spectinomycin has few resistant strains. Spectinomycin is well absorbed ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/357A61K36/81A61P1/12A61P31/04A61P29/00
Inventor 梁金权
Owner CHONGQING ZONGYI PHARMA
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