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Progesterone receptor modulators for use in preventing or treating androgen mediated diseases

A technology of progesterone receptors and modulators, applied in the direction of diseases, skin diseases, urinary system diseases, etc., can solve unsatisfied problems

Inactive Publication Date: 2015-03-11
PREGLEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although this treatment option exists and can manage the symptoms of PCOS, it is suboptimal
[0020] Thus, there remains a significant unmet need for effective and better long-term therapies for androgen-mediated diseases such as BPH, PMS, PCOS, prostate cancer, hirsutism, acne, seborrhea, and androgenetic alopecia. need

Method used

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  • Progesterone receptor modulators for use in preventing or treating androgen mediated diseases
  • Progesterone receptor modulators for use in preventing or treating androgen mediated diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Example 1: Antiandrogen in a 4-week oral toxicity study of ulipristal acetate in mice prime effect.

[0068] Table 1: 4-Week Oral Toxicity Study of UPA in Mice - Organ Weights

[0069]

[0070] result:

[0071] These toxicity studies revealed that the seminal vesicles, prostate, and epididymis are androgen-responsive organs. The reduction in organ weights under the action of UPA suggests that UPA is antiandrogen-like.

Embodiment 2

[0072] Embodiment 2: Ulipristal acetate anti-cancer effect in 26 weeks of oral carcinogenicity studies carried out in mice androgenic effects .

[0073] Table 2: 26-week oral carcinogenicity study of UPA in mice - organ weights

[0074]

[0075] result:

[0076] These toxicity studies revealed that the seminal vesicles, prostate, and epididymis are androgen-responsive organs. The reduction in organ weights under the action of UPA suggests that UPA is anti-androgenic.

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PUM

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Abstract

The present invention relates generally to a progesterone receptor modulator, or any metabolite thereof for use in the prevention or treatment of androgen mediated diseases characterized in that said progesterone receptor modulator, or any metabolite thereof, is administered to a subject in need thereof.

Description

technical field [0001] The present invention generally relates to methods for the prevention or treatment of androgen-mediated diseases, in particular for the prevention or treatment of benign prostatic hyperplasia, premenstrual syndrome, polycystic ovary syndrome, prostate cancer, hirsutism, acne, sebum Method for overflowing, androgenic alopecia. technical background [0002] Many patients with androgen-mediated disorders require intervention to improve disease symptoms. [0003] The androgen receptor (AR), a member of the steroid / nuclear receptor superfamily, plays a key role in normal male development, including that of the prostate. [0004] Furthermore, AR has a fundamental role in the development and progression of eg prostate cancer or benign prostatic hyperplasia in men [Hodgson, 2004]. Studies involving the AR receptor have revealed that in most cases of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) in women, these conditions appear to be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/00A61K31/57A61P5/24A61P15/12A61P17/10A61P17/14A61P17/08A61P35/00A61P13/08
CPCA61K31/00A61K31/57A61P13/08A61P15/00A61P15/12A61P17/00A61P17/02A61P17/06A61P17/08A61P17/10A61P17/14A61P35/00A61P43/00A61P5/24A61P5/26A61P5/28
Inventor O·波尔J-P·戈特兰
Owner PREGLEM