Biomarkers for triple negative breast cancer

A triple-negative breast cancer, biomarker technology, applied in the field of biomarkers, can solve problems such as poor prognosis and survival rate, lack of

Inactive Publication Date: 2015-03-25
ERASMUS UNIV MEDICAL CENT ROTTERDAM ERASMUS MC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Women with triple-negative subtypes of breast cancer have poor prognosis and survival compared with other subtypes due to the aggressive nature of these tumors and the current lack of suitable targets for treatment

Method used

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  • Biomarkers for triple negative breast cancer
  • Biomarkers for triple negative breast cancer
  • Biomarkers for triple negative breast cancer

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Embodiment Construction

[0043] definition

[0044] For the purposes of the present invention, a biomarker may be a protein or nucleic acid encoding a protein, a peptide or a metabolite. Preferred biomarkers according to the invention and / or embodiments thereof are proteins, peptides or nucleic acids encoding proteins. Most preferred biomarkers according to the invention and / or embodiments thereof are proteins or peptides and / or fragments of said proteins and / or peptides.

[0045] The present invention and embodiments thereof relate to biomarkers detectable in biological samples. The biological sample may optionally consist of breast tissue, blood, lymph, serum, urine, circulating cancer cells, and / or nipple discharge.

[0046] For the present invention, poor prognosis was defined as the occurrence of distant metastases within 5 years of diagnosis.

[0047] Good prognosis was defined as freedom from metastasis within 5 years of diagnosis.

[0048] Survival increases are based on Kaplan Meier survi...

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Abstract

The present invention relates to biomarkers that are useful in the prognosis of triple negative breast cancer patients. The biomarkers may be used to select treatment and to determine whether a treatment is effective or not. The biomarkers may also be used to select novel treatments and to screen for new potential compounds that may treat the triple negative breast cancer.

Description

technical field [0001] The present invention relates to biomarkers for determining the prognosis of triple negative breast cancer. The present invention further relates to methods for determining the treatment of triple-negative breast cancer and / or determining the effect of treatment on triple-negative breast cancer and screening compounds for triple-negative breast cancer. Background technique [0002] Breast cancer affects 1 in 8 women during their lifetime and is responsible for approximately 458,000 deaths worldwide each year. Most tumor cells are usually derived from the epithelium lining the milk ducts or lobules. Histopathological parameters such as tumor grade, stage, and lymph node or distant metastasis have become the gold standard for predicting prognosis. Breast cancer is a very heterogeneous disease, composed of different molecular subtypes. Molecular subtypes of breast cancer defined by gene expression profiles were first described a decade ago as biologica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574C12Q1/68
CPCC12Q1/6886C12Q2600/118C12Q2600/158G01N33/57415G01N2500/04G01N2800/52
Inventor 阿尔祖·奥马尔约翰内斯·艾伯特·弗肯斯
Owner ERASMUS UNIV MEDICAL CENT ROTTERDAM ERASMUS MC
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