Balloon catheter
A balloon catheter and balloon technology are applied in the field of drug-eluting balloon catheters and their preparation, which can solve the problems of drug coating damage, need, life-threatening and the like, achieve good mutual compatibility, reduce drug loss, increase The effect of firmness
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[0047] Example 1
[0048] Such as figure 1 As shown, take 5 3.0mm*20mm (diameter * length) balloon catheters (material: Pebax, block polyetheramide), the balloon is the balloon 1 in the schematic diagram, the balloon surface is 2, and 75 Wipe clean with% ethanol and set aside.
[0049] Dissolve 500mg paclitaxel and appropriate amount of polyethylene glycol in ethanol to prepare a solution with a drug concentration of 50mg / ml, and spray this solution on the surface of the balloon to form a drug loading of 5μg / mm 2 The first drug-loaded coating 4 has a coating thickness of 5μm.
[0050] Dissolve 200mg paclitaxel and appropriate amount of polyethylene glycol in ethanol to prepare a solution with a drug concentration of 20mg / ml, and spray this solution on the surface of the balloon to form a drug loading of 2μg / mm 2 The second drug-loaded coating 5 has a coating thickness of 2.5μm.
[0051] After drying, folding, and packaging, the resulting drug-eluting balloon catheter is called DEB1.
Example Embodiment
[0052] Example 2
[0053] Such as figure 2 As shown, take 5 3.0mm*20mm (diameter * length) balloon catheters (material: Pebax), the balloon is balloon 1 in the schematic diagram, and the balloon surface is 2, wipe it clean with 75% ethanol. spare.
[0054] Dissolve 500mg paclitaxel and appropriate amount of polyethylene glycol in ethanol to prepare a solution with a drug concentration of 50mg / ml, and spray this solution on the surface of the balloon to form a drug loading of 5μg / mm 2 The first drug-loaded coating 4 has a coating thickness of 5μm.
[0055] Dissolve 200mg paclitaxel and appropriate amount of polyethylene glycol in ethanol to prepare a solution with a drug concentration of 20mg / ml, and spray this solution on the surface of the balloon to form a drug loading of 2μg / mm 2 The second drug-loaded coating 5, the coating thickness is 1μm.
[0056] Dissolve 100mg paclitaxel and appropriate amount of polyethylene glycol in ethanol to prepare a solution with a drug concentration ...
Example Embodiment
[0058] Example 3
[0059] Such as figure 2 As shown, take 5 3.0mm*20mm (diameter * length) balloon catheters (material: nylon), the balloon is the balloon 1 in the schematic diagram, and the balloon surface is 2, wipe it clean with 75% ethanol. spare.
[0060] The plasma cleaning technology is used to clean debris on the surface of the balloon, and the plasma cleaning time is 15 minutes. Plasma cleaning technology uses inert gas as argon, power is 10KHz-100KHz, and the pressure in the working chamber during cleaning is 0.01atm-0.3atm.
[0061] Dissolve 500 mg of rapamycin and appropriate amount of polyethylene glycol-polycaprolactone in ethanol to prepare a solution with a drug concentration of 50 mg / ml, and spray the solution on the surface of the balloon to form a drug loading of 5 μg / mm 2 The first drug-loaded coating 4, the coating thickness is 10μm.
[0062] Dissolve 200 mg of rapamycin and an appropriate amount of polyethylene glycol-polycaprolactone in ethanol to prepare a ...
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