Balloon catheter

A balloon catheter and balloon technology are applied in the field of drug-eluting balloon catheters and their preparation, which can solve the problems of drug coating damage, need, life-threatening and the like, achieve good mutual compatibility, reduce drug loss, increase The effect of firmness

Inactive Publication Date: 2015-04-15
SHENZHEN SALUBRIS BIOMEDICAL ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It uses laser drilling or etching technology to make microholes, which not only requires expensive equipment, but also has a complicated process, which is not suitable for industrial production
In addition, although the density of laser drilling is high, microcracks are likely to be generated around the microholes during the laser high-heat fusion microhole process, thereby affecting the mechanical strength of the balloon; etching technology is easy to ionize molecules around the microholes, thereby breaking the polymer chain
[0005] Chinese patent CN101785900A discloses a drug-eluting balloon catheter and its preparation method. The drug-eluting balloon catheter adopts ultraviolet laser grinding to process the outer surface of the balloon, so that the surface of the balloon forms a convex-concave non-planar structure, thereby improving the performance of t

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0047] Example 1

[0048] Such as figure 1 As shown, take 5 3.0mm*20mm (diameter * length) balloon catheters (material: Pebax, block polyetheramide), the balloon is the balloon 1 in the schematic diagram, the balloon surface is 2, and 75 Wipe clean with% ethanol and set aside.

[0049] Dissolve 500mg paclitaxel and appropriate amount of polyethylene glycol in ethanol to prepare a solution with a drug concentration of 50mg / ml, and spray this solution on the surface of the balloon to form a drug loading of 5μg / mm 2 The first drug-loaded coating 4 has a coating thickness of 5μm.

[0050] Dissolve 200mg paclitaxel and appropriate amount of polyethylene glycol in ethanol to prepare a solution with a drug concentration of 20mg / ml, and spray this solution on the surface of the balloon to form a drug loading of 2μg / mm 2 The second drug-loaded coating 5 has a coating thickness of 2.5μm.

[0051] After drying, folding, and packaging, the resulting drug-eluting balloon catheter is called DEB1.

Example Embodiment

[0052] Example 2

[0053] Such as figure 2 As shown, take 5 3.0mm*20mm (diameter * length) balloon catheters (material: Pebax), the balloon is balloon 1 in the schematic diagram, and the balloon surface is 2, wipe it clean with 75% ethanol. spare.

[0054] Dissolve 500mg paclitaxel and appropriate amount of polyethylene glycol in ethanol to prepare a solution with a drug concentration of 50mg / ml, and spray this solution on the surface of the balloon to form a drug loading of 5μg / mm 2 The first drug-loaded coating 4 has a coating thickness of 5μm.

[0055] Dissolve 200mg paclitaxel and appropriate amount of polyethylene glycol in ethanol to prepare a solution with a drug concentration of 20mg / ml, and spray this solution on the surface of the balloon to form a drug loading of 2μg / mm 2 The second drug-loaded coating 5, the coating thickness is 1μm.

[0056] Dissolve 100mg paclitaxel and appropriate amount of polyethylene glycol in ethanol to prepare a solution with a drug concentration ...

Example Embodiment

[0058] Example 3

[0059] Such as figure 2 As shown, take 5 3.0mm*20mm (diameter * length) balloon catheters (material: nylon), the balloon is the balloon 1 in the schematic diagram, and the balloon surface is 2, wipe it clean with 75% ethanol. spare.

[0060] The plasma cleaning technology is used to clean debris on the surface of the balloon, and the plasma cleaning time is 15 minutes. Plasma cleaning technology uses inert gas as argon, power is 10KHz-100KHz, and the pressure in the working chamber during cleaning is 0.01atm-0.3atm.

[0061] Dissolve 500 mg of rapamycin and appropriate amount of polyethylene glycol-polycaprolactone in ethanol to prepare a solution with a drug concentration of 50 mg / ml, and spray the solution on the surface of the balloon to form a drug loading of 5 μg / mm 2 The first drug-loaded coating 4, the coating thickness is 10μm.

[0062] Dissolve 200 mg of rapamycin and an appropriate amount of polyethylene glycol-polycaprolactone in ethanol to prepare a ...

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Abstract

The invention provides a medicine eluting balloon catheter. The medicine eluting balloon catheter has the characteristics of simple structure, simple production process, less loss of medicines in a conveying process, and less medicine residue amount on a balloon after interventional operation. The medicine eluting balloon catheter has a simple structure and is also suitable for large-scale production.

Description

technical field [0001] The invention relates to a medical device, in particular to a drug-eluting balloon catheter for interventional treatment of cardiovascular diseases and a preparation method thereof. technical background [0002] Drug-eluting balloon catheter is a combination of traditional balloon angioplasty and advanced drug-eluting technology. Drug-eluting balloon catheter can release drugs immediately and quickly when the balloon reaches the lesion during interventional treatment, avoiding metal stents and The side effects caused by the long-term retention of polymer carriers are an effective supplement to metal stent angioplasty. There is also a large loss of drugs on the surface of the balloon during the intervention process, resulting in a low drug loading rate in the diseased tissue, and some drugs still adhere to the surface of the balloon after interventional treatment due to the existence of surface binding force (approximately 10-20%), affecting the releas...

Claims

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Application Information

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IPC IPC(8): A61M25/10A61M31/00
Inventor 刘庄申峰袁玲
Owner SHENZHEN SALUBRIS BIOMEDICAL ENG CO LTD
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