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Method for generating chemical patterns in microfluidic structures

A microfluidic, patterned technology with applications in chemical instruments and methods, nanotechnology for materials and surface science, layered products, etc.

Active Publication Date: 2017-09-12
因美纳股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, challenges arise in the fabrication of flow cells using semiconductor processes due to compatibility issues between semiconductor manufacturing processes and biological applications, as well as limitations and / or limitations on semiconductor manufacturing processes

Method used

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  • Method for generating chemical patterns in microfluidic structures
  • Method for generating chemical patterns in microfluidic structures
  • Method for generating chemical patterns in microfluidic structures

Examples

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Embodiment Construction

[0033] It should be understood that the following disclosure provides many different embodiments or examples for implementing different features of the present invention. Specific examples of components and arrangements are described below to simplify the present disclosure. Of course, these are only examples and are not intended to limit the invention. Moreover, in the following description, forming a first component over or on a second component may include embodiments in which the first component and the second component are in direct contact, and may also include an additional component may be formed between the first component and the second component. An embodiment in which the space between the first part and the second part is not in direct contact. Additionally, spatially relative terms such as "top," "front," "bottom," and "rear" may be used herein to provide relative relationships between elements and are not intended to imply any absolute orientation. Various fea...

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Abstract

The present invention provides flow cells and methods of making flow cells. The method includes assembling three parts: a first substrate, a second substrate, and a microfluidic flow channel between the first substrate and the second substrate, the microfluidic flow channel having a wall of a dry film of photoresist . Through holes for inlets and outlets are formed in the first substrate or the second substrate. The patterned trapping dots are imprinted on the first substrate and the second substrate by a nanoimprint lithography process. In other embodiments, the partially patterned capture dots are selectively adhered to a pattern of surface chemistry formed from silicon oxide islands respectively disposed on exposed portions of the soft underlayer.

Description

technical field [0001] The present invention relates to biosensors and methods of forming biosensors. More specifically, the present invention relates to microfluidic devices and methods of forming them. Background technique [0002] Biosensors are devices for sensing and detecting biomolecules and operate based on electronic, electrochemical, optical and / or mechanical detection principles. Biosensors can sense charges, photons, and mechanical properties of living organisms or biomolecules, or through molecular tags. Detection can be performed by detecting the organism or biomolecule itself or by the interaction and reaction between specific reactants and the organism or biomolecule. Biosensors continue to be miniaturized to reduce sample size while improving sensitivity and increasing information content. [0003] A flow cell is a type of biosensor that includes a microfluidic structure that allows external detection of its content through a transparent window, using eg ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/05
CPCB01L2300/0636B01L2300/0877B01L2300/0887B01J2219/00286B01J2219/00382B01J2219/00637B82Y30/00B01L3/502707B01L3/502715B01L2200/12B01L2300/0896B01L2300/12B32B37/30B32B2307/412
Inventor 蔡尚颖洪丽閔彭荣辉
Owner 因美纳股份有限公司
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