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Common rush hemostatic capsule as well as preparation and identification method thereof

A technology of capsules and wicks, applied in the directions of capsule delivery, blood diseases, pharmaceutical formulations, etc., can solve the problems of large side effects, easy to produce salicylic acid reaction, etc., and achieve the effects of non-irritating, fast absorption and high curative effect.

Inactive Publication Date: 2015-04-22
HUBEI FUREN JINSHEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] There are many hemostatic drugs, most of which are western medicines, such as Anluoxue. Although they have a good hemostatic effect, they have relatively large side effects and are prone to salicylic acid reactions. People with a history of epilepsy or mental illness should use them with caution

Method used

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  • Common rush hemostatic capsule as well as preparation and identification method thereof
  • Common rush hemostatic capsule as well as preparation and identification method thereof

Examples

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preparation example Construction

[0033] A preparation method of Dengxin Zhixue Capsules, comprising the steps of:

[0034] ①. Mix Sichuan rushes, velvet velvet and iron amaranth in proportion to obtain a coarse mixture, add water 10 to 15 times the weight of the coarse mixture and decoct for 2 to 4 hours, pour out the liquid to obtain the first secondary decoction;

[0035] ② Add water 10 to 12 times the weight of the coarse mixture for decoction again, decoct for 1 to 3 hours, pour out the liquid to obtain the second decoction;

[0036] ③. Combine and filter the decoctions obtained twice to obtain a filtrate, and concentrate the filtrate at 70-75°C to a relative density of 1.05-1.15, and then cool to room temperature;

[0037] ④. Add ethanol to make the alcohol content reach more than 50%, let it stand for 24 to 48 hours, filter and obtain the supernatant and precipitate;

[0038] ⑤. Add an equal amount of 50% ethanol to the precipitate, stir well, let stand for 24-48 hours, and filter to obtain the supern...

Embodiment 1

[0042] ①. Mix 1000g of Sichuan rushes, 1000g of velvet velvet and 100g of amaranth to obtain a coarse mixture, add 30kg of water to decoct, decoct for 2 hours, pour out the liquid to obtain the first decoction;

[0043] ②, Add 30kg of water again to decoct, decoct for 1 hour, pour out the liquid to obtain the second decoction;

[0044] ③. Merge and filter the decoctions obtained twice to obtain a filtrate, and concentrate the filtrate at 70 to a relative density of 1.05, and then cool to room temperature;

[0045] ④. Add ethanol to make the alcohol content reach 50%, let stand for 24 hours, filter and obtain supernatant and precipitate;

[0046] ⑤. Add an equivalent amount of 50% ethanol to the precipitate, stir well, let stand for 24 hours, and filter to obtain the supernatant;

[0047]6. Combine the supernatant obtained twice in step ④ and step ⑤, concentrate at 70°C to a relative density of 1.1, and add 24g of dextrin while hot, mix well, spray dry, and collect the spray-d...

Embodiment 2

[0050] ①. Mix 1000g of Sichuan rushes, 1000g of velvet velvet and 100g of amaranth to obtain a coarse mixture, add 36kg of water to decoct, decoct for 3 hours, pour out the liquid to obtain the first decoction;

[0051] ②, add 33kg of water again to decoct, decoct for 2 hours, pour out the liquid to obtain the second decoction;

[0052] ③. Combine and filter the decoction obtained twice to obtain a filtrate, and concentrate the filtrate at 72°C to a relative density of 1.1, and then cool to room temperature;

[0053] ④. Add ethanol to make the alcohol content reach 55%, let stand for 36 hours, filter and obtain supernatant and precipitate;

[0054] ⑤. Add an equivalent amount of 50% ethanol to the precipitate, stir well, let stand for 36 hours, and filter to obtain the supernatant;

[0055] ⑥. Combine the supernatant obtained twice in step ④ and step ⑤, concentrate at 72°C to a relative density of 1.15, and add 27g of dextrin while hot, mix well, spray dry, and collect the sp...

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Abstract

The invention discloses a common rush hemostatic capsule as well as preparation and identification method thereof. The preparation and identification method comprises the following steps: mixing Szechuan common rush, tomentose agrimony and copperleaf herb together in the weight ratio of 1: 1: 1, adding water in two steps for decocting, obtaining the filtrate, concentrating the filtrate and cooling the filtrate until a room temperature; adding ethanol to the filtrate for standing, and filtering to obtain the liquid supernatant and the precipitate; filtering the precipitate by use of ethanol to obtain the liquid supernatant; blending the liquid supernatants obtained twice, concentrating at a certain temperature, adding dextrin while hot, mixing evenly, spray-drying, and collecting a spray-dried powder; adding the dextrin, calcium hydrophosphate and starch, mixing evenly, forming a soft material by use of 80% ethanol, pelleting, drying particles at 50 DEG C, adding magnesium stearate and mixing evenly, and putting the mixture into capsules. The obtained common rush hemostatic capsules are capable of clearing heat and promoting dieresis, and astringing to stop bleeding, and contain over 2.5mg / g of gallic acid. The common rush hemostatic capsules can be applied to internal hemorrhoid hemorrhage, hyporrhea after artificial abortion operations and intrauterine device insertion, and the like. Furthermore, the common rush hemostatic capsules are quick to absorb, high in curative effect, non-irritating to intestines and stomach, and also free from side effect.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and specifically relates to a Dengxin hemostatic capsule used for treating internal hemorrhoid bleeding, mild bleeding after artificial abortion, and intrauterine device placement, and a preparation and identification method thereof. Background technique [0002] There are many hemostatic drugs, most of which are western medicines, such as Anluoxue. Although they have a good hemostatic effect, they have relatively large side effects and are prone to salicylic acid reactions. People with a history of epilepsy or mental illness should use them with caution. However, there are not many hemostatic drugs in traditional Chinese medicine prescriptions. [0003] In the Chinese patent application number 00128137.2, a hemostatic capsule and a preparation method thereof for treating hemoptysis, hematemesis, epistaxis, gastrointestinal bleeding and the like caused by blood-heat rash are disclosed. It conta...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61K9/48A61P7/04G01N30/90
CPCA61K9/4866A61K36/47A61K36/73A61K36/88A61K2236/331A61K2236/39A61K2236/51A61K2236/53G01N30/90A61K2300/00
Inventor 吴宇星邹鹏程吴相梧李捷吴和鸣曾希望吴正开
Owner HUBEI FUREN JINSHEN PHARMA
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