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Aspirin composition freeze-dried tablets and preparation method thereof

A technology for aspirin and composition, which is applied in the field of aspirin composition freeze-dried tablet and its preparation, and achieves the effects of large dissolution rate, high bioavailability and good formability

Inactive Publication Date: 2015-04-29
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Starch is the basic excipient of oral solid preparations. It is formed by the polymerization of glucose molecules. It is often used as a binder, diluent and disintegrating agent in tablets. It is cheap and easy to obtain, and is safe for the human body. However, starch is used alone as an excipient There is no report on the production of aspirin freeze-dried tablets by freeze-drying process

Method used

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  • Aspirin composition freeze-dried tablets and preparation method thereof
  • Aspirin composition freeze-dried tablets and preparation method thereof
  • Aspirin composition freeze-dried tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]

[0028] A. Weigh 100g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 5-7.5, then heat to 72°C and keep for 120 minutes to make 9% (W / V) cornstarch solution.

[0029] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0030] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.

[0031] D. Weigh 50 g of aspirin, add it into 1 L of corn-sucrose solution, and stir for 30 minutes.

[0032] E. After measuring the aspirin content of the medicinal solution, divide the...

Embodiment 2

[0035]

[0036] A. Weigh 130g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 5-7.5, then heat to 72°C and keep for 120 minutes to make 13% (W / V) cornstarch solution.

[0037] B. Measure 45ml of purified water, boil it, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0038] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.

[0039] D, take by weighing 50 grams of aspirin (calculated as 1000 tablets), add 1L corn-sucrose solution, and stir for 30 minutes.

[0040] E. After measuring the aspirin content o...

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Abstract

The invention provides aspirin composition freeze-dried tablets and a preparation method thereof, and relates to the technical field of medicine and medicine production. The aspirin composition freeze-dried tablets comprise aspirin, starch and sucrose, wherein starch and sucrose are used as accessories. Ordinary corn starch is treated by a heating process, so that the bonding and disintegration effects of starch in the tablets can be improved, and the forming property of the tablets can be improved; only starch and sucrose are required to be used as the accessories of the aspirin composition freeze-dried tablets. A two-cooling two-heating freeze-drying process is adopted for the aspirin composition freeze-dried tablets, and by twice cooling and twice heating, better forming property of the tablets can be achieved, and the dissolubility of the tablets is improved, so that the bioavailability of the tablets is improved. According to the tablets, the defects of ordinary aspirin tablets are overcome, the sort and using amounts of the accessories in the aspirin tablets are reduced, the tablets are high in dissolubility and bioavailability, and the curative effects and safety of clinical mediation are ensured.

Description

technical field [0001] The invention relates to the technical field of medicine and medicine production, in particular to a freeze-dried tablet of aspirin composition and a preparation method thereof. Background technique [0002] Aspirin, also known as acetylsalicylic acid, is an antipyretic and analgesic with a long history, which was born on March 6, 1899. It is used to treat colds, fever, headache, toothache, arthralgia, rheumatism, and can also inhibit platelet aggregation. It can also be used to prevent and treat ischemic heart disease, angina pectoris, cardiopulmonary infarction, and cerebral thrombosis. It can also increase the germination rate of plants. , It is also effective in angioplasty and bypass grafting. [0003] structural formula [0004] Molecular weight: 180.16 [0005] Ordinary aspirin tablets contain many types and quantities of excipients. Generally, fillers, lubricants, disintegrants, binders, flavoring agents, etc. are used. , the dissolution ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/616A61K47/36A61K47/26A61P11/00A61P29/00A61P25/00A61P1/02A61P19/02A61P7/02A61P9/10
Inventor 李祖红汪宁卿李珠珠饶经纬李彪
Owner HAINAN WEI KANG PHARMA QIANSHAN
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