Silver nanometer cluster compound with antibacterial activity and preparation method thereof

A technology of antibacterial activity and cluster compound, which is applied in the field of nano silver cluster compound and its preparation, can solve the problems of low activity, cannot be formulated into a solution preparation, instability, etc., and achieves the effect of strong antibacterial activity

Inactive Publication Date: 2015-05-06
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This new technology allows silvers containing metal particles called gold or platinaium atoms to create an organopolymer material that becomes very small when exposed to sunlight without losing their effectiveness over longer periods due to being able to store energy within them inside itself instead of relying solely upon absorption through reflection from other surfaces like mirrors. It also provides anti bacteria ability even if there are no substances attached to these materials themselves.

Problems solved by technology

The technical problem addressed by this patented technology relates to finding an effective way for metal nanoparms to fight against bacteria without harming their healthy cells due to their ability to kill germs effectively on contact.

Method used

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  • Silver nanometer cluster compound with antibacterial activity and preparation method thereof
  • Silver nanometer cluster compound with antibacterial activity and preparation method thereof
  • Silver nanometer cluster compound with antibacterial activity and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0024] The selection and determination of embodiment 1 synthesis conditions

[0025] Selection of photochemical reaction light source

[0026] For general photochemical reactions, it is better to use a monochromatic light source, which can produce relatively simple products and avoid other side reactions. Therefore, this preparation uses a monochromatic light source. First use monochromatic light sources with different wavenumbers for photocatalytic reactions (720nm, 505nm, 405nm, 365nm, 300nm and 254nm). , is very fast compared to the first two light sources with different wavelengths. Although the difference is not very large, there are also differences between them. In short, the shorter the wavelength, the higher the energy and the faster the reaction ( image 3 shown). Explain that to ensure that the reaction is completed quickly, the relatively high energy of the monochromatic light source is a crucial factor. Not only the photocatalytic reaction at 300nm is the seco...

Embodiment 2

[0034] The preparation of embodiment 2 polymer nano-silver clusters:

[0035] 1) Mixing polymethylmethacrylate and polyvinylpyrrolidone in a mass ratio of 1:1, and preparing a 10 mM aqueous solution of polymer monomers for later use;

[0036] 2) Mix 10 ml of silver nitrate aqueous solution (10mM) with 5 ml of polymer monomer aqueous solution, stir at room temperature for at least 10 minutes to form a light yellow transparent solution, encapsulate it in a 20 ml glass bottle, and then use a 300nm monochromatic Light source radiation (0.5mW), covered with metal aluminum foil around, continuous irradiation for 24 hours to complete the reaction;

[0037] 3) The reaction solution is dialyzed to remove small impurity molecules to obtain pure nano-silver clusters.

[0038] The mass spectrogram obtained by measuring the final product with a mass spectrometer is shown in Figure 5 , Figure 6 . It shows that the product contains the following silver atom cluster Ag 2 、Ag 3 、Ag 4 ...

Embodiment 3

[0039] The antimicrobial activity experiment of embodiment 3 macromolecule nano-silver cluster compound:

[0040] The antibacterial activity test on Staphylococcus aureus has a minimum inhibitory concentration (MIC) of 5 μg / mL, which has reached the lowest concentration limit that can be achieved by the best products of the same kind abroad. Adopt the solution of 0.5mg / mL concentration to carry out activity test, experimental result is as follows Figure 7 As shown in , after 4 hours, the number of colony-forming units in the experimental observation group was close to the minimum detection limit of the experiment compared with the blank comparison, which was reduced by 10 7 times. The results of the antibacterial activity test on a single bacterium show that our products have reached the same level of antibacterial activity as similar products in the world, and our products have stability and variety of forms that other similar products do not have.

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Abstract

The invention discloses a silver nanometer cluster compound with an antibacterial activity and a preparation method thereof. The silver nanometer cluster compound is prepared by adopting biocompatible polymers and metal silver ions which produce polymer-included stable solution of the nanometer silver cluster compound under illumination. The nanometer silver cluster compound has physical properties, such as surface isoiony, of metal silver nanoparticles, can absorb visible light, thus loses sensitivity to light, can stably exist in solution for a long term, has a high surface area reaction activity of metal silver nanoparticles and has a stronger antibacterial activity. According to antibacterial activity experiments on staphylococcus aureus, the minimum inhibition concentration (MIC) is 5mu g/mL, which has already reached the lowest concentration limit which can be reached by the domestic and overseas similar best products.

Description

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Claims

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Application Information

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Owner SHANXI UNIV
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