2results about How to "Change sensitivity" patented technology

The invention relates to an application of suramine in promoting tumor radiotherapy sensitization. The invention fully proves that suramin can effectively prepare tumor cells in a state highly sensitive to ferroptosis through a novel metabolic reprogramming mechanism of inhibiting IPPK, reducing IP6 and releasing Fe < 2 + > chelated with an iron pool in cells, thereby creating necessary biochemical conditions for ferroptosis; and the sensitivity of cells to ferroptosis induced stimulation is fundamentally changed. Therefore, the compound can be used as a ferroptosis inducer and a potent sensitizer for radiotherapy at the same time. The discovery not only provides a new combined strategy for overcoming tumor treatment resistance, but also perfectly explains the transformation medicine concept of new use of old medicines, and provides a new active ingredient for human tumor treatment, thereby providing a new direction for subsequent medicine research and development, clinical treatment and the like, and having extremely high social value and market application prospects.

The utility model belongs to the technical field of belt conveyor, concretely is a kind of mine double drum temperature control device, including two groups of temperature control unit respectively corresponding to two drums, temperature control unit includes spray pipeline, fan-shaped nozzle, infrared temperature sensor and electromagnetic ball valve, spray pipeline is set in the side of drum and is parallel with the setting of drum, fan-shaped nozzle is provided with multiple on spray pipeline, infrared temperature sensor is set in the side of drum, electromagnetic ball valve is set in the water inlet end of spray pipeline, for control spray pipeline opening and closing, and the electromagnetic ball valve in two groups of temperature control unit, infrared temperature sensor are connected with PLC control system.This utility model can realize the automatic alarm of drum overtemperature and the automatic start spray cooling function after overtemperature, without manual intervention, system response is sensitive, improve the service life of drum and coal mine equipment, improve the safety of coal mine production operation.