Traditional Chinese medicine composition with anti-hepatitis B and C virus activity

A technology of hepatitis C virus and composition, which is applied in antiviral agents, drug combinations, medical preparations containing active ingredients, etc., can solve the problems of undiscovered hepatitis C virus reports of rhubarb saltpeter soup, and improve the dependence , easy to carry and take, and the effect of inhibiting the replication of hepatitis virus

Active Publication Date: 2015-05-20
阿南达
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, there is no report about the anti-hepatitis B virus and hepatitis C virus of rhubarb saltpeter soup

Method used

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  • Traditional Chinese medicine composition with anti-hepatitis B and C virus activity
  • Traditional Chinese medicine composition with anti-hepatitis B and C virus activity
  • Traditional Chinese medicine composition with anti-hepatitis B and C virus activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Take 2700g gardenia, decoct and extract twice, add 32L water each time and decoct for 1 hour, filter the decoction while it is hot, combine the two decoctions, concentrate to 0.5g crude drug / mL, and load gardenia per mL of resin The amount of 1.5g of the crude drug is loaded into HPD-100 type macroporous resin, washed with water until clarified, then eluted to colorless with 75% ethanol, collected the ethanol eluate, dried at low temperature after recovering the solvent, and pulverized into fine powder to obtain 200g gardenia refined components.

[0044] Take 1800g of rhubarb, decoct and extract 3 times, add 18L of water to decoct for 0.5h each time, filter the decoction while it is hot, combine the decoction for 3 times, concentrate to 0.75g crude drug / mL, and load rhubarb as per mL of resin Crude drug amount 0.94g sample AB-8 type macroporous resin, washed to clarification, then eluted to colorless with 95% ethanol, collected ethanol eluate, recovered solvent, dried a...

Embodiment 2

[0049] Take 1350g gardenia, decoct and extract 3 times, add 13L water each time and decoct for 1 hour, filter the decoction while it is hot, combine the decoction for 3 times, concentrate to 0.5g crude drug / mL, and load gardenia per mL of resin The amount of 1.5g of the crude drug is loaded into HPD-100 type macroporous resin, washed with water until clarified, then eluted to colorless with 75% ethanol, collected the ethanol eluate, dried at low temperature after recovering the solvent, and pulverized into fine powder to obtain 103g gardenia refined components.

[0050] Take 900g of rhubarb, decoct and extract twice, add 12L of water each time and decoct for 1 hour, filter the decoction while it is hot, combine the two decoctions, concentrate to 0.75g crude drug / mL, and load rhubarb crude drug per mL of resin Load 0.94g of sample AB-8 macroporous resin, wash with water until clarification, then elute with 95% ethanol until colorless, collect the ethanol eluate, recycle the sol...

Embodiment 3

[0055] Take 270g of gardenia, decoct and extract twice, add 3L of water each time and decoct for 1 hour, filter the decoction while it is hot, combine the two decoctions, concentrate to 0.5g crude drug / mL, and load gardenia per mL of resin The amount of 1.5g of the crude drug is loaded into HPD-100 type macroporous resin, washed with water until clarified, then eluted to colorless with 75% ethanol, collected the ethanol eluate, dried at low temperature after recovering the solvent, and pulverized into fine powder to obtain 20g gardenia refined components.

[0056] Take 180g of rhubarb, decoct and extract twice, add 2L of water each time and decoct for 0.5h, filter the decoction while hot, combine the two decoctions, concentrate to 0.75g crude drug / mL, and load rhubarb as per mL of resin The amount of crude drug is 0.94g, loaded with AB-8 macroporous resin, washed with water until clarified, then eluted with 95% ethanol until colorless, collected the ethanol eluate, recovered t...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition with anti-hepatitis B and C virus activity. The composition is prepared from the following medicinal raw materials in parts by weight: 4-15 parts of cape jasmine, 6-18 parts of rheum officinale, 6-18 parts of cortex phellodendri and 3-12 parts of mirabilite. Pharmacodynamic researches indicate that the traditional Chinese medicine composition can be used for well inhibiting expression of HBV genome stably transfected HepG2 cell line HBeAg and HBsAg antigens, achieves a certain effect of anti-HBV activity, can be used for remarkably inhibiting expression of Rluc in infected HCV (JFH1-luc) report virus Huh7.5.1 cell culture solution and reducing the content of HCV-RNA to show good anti-HCV activity, and indicates the treatment effect of inhibiting activity of hepatitis B and C viruses.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for viral hepatitis. The traditional Chinese medicine composition of the invention has activity for both hepatitis B and hepatitis C viruses. Background technique [0002] Hepatitis virus refers to the pathogen that causes viral hepatitis, including hepatitis A, B, C, D, E and other hepatitis viruses. Among them, hepatitis B and C viruses are mostly simultaneously or superimposedly infected with other types of hepatitis viruses, which is one of the main causes of chronic hepatitis, liver cirrhosis and liver cancer. [0003] my country is an area with a high incidence of hepatitis, and hepatitis diseases are on the rise year by year. Viral hepatitis ranks first among all types of hepatitis diseases, among which hepatitis B and C virus infections are the most common. It has the characteristics of high rate and difficult cure, which seriously threatens human health and life. [0004] Mod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61P31/20A61P31/14A61P1/16A61K33/04
Inventor 裴妙荣孔祥鹏李慧峰
Owner 阿南达
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