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High-stability compound liquorice oral solution and preparation method thereof

A compound licorice, oral solution technology, applied in the directions of pharmaceutical formulations, organic active ingredients, medical preparations of non-active ingredients, etc., can solve the problems of toxic dimorphine, oxidative discoloration, unstable aqueous solution, etc., and achieve stable product quality, The effect of preventing oxidation

Active Publication Date: 2015-05-27
北京海德润医药集团有限公司
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AI Technical Summary

Problems solved by technology

Due to the existence of the 3-position phenolic hydroxyl group of morphine, the aqueous solution of morphine and its salt is unstable, and it is easily oxidized and discolored by oxygen in the air during the storage process, resulting in highly toxic bimorphine

Method used

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  • High-stability compound liquorice oral solution and preparation method thereof
  • High-stability compound liquorice oral solution and preparation method thereof
  • High-stability compound liquorice oral solution and preparation method thereof

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preparation example Construction

[0023] On the other hand, the present invention also provides a preparation method of the above-mentioned highly stable compound licorice oral solution, figure 1 A schematic flow chart of the preparation method of the present invention is shown. Such as figure 1 As shown, the method includes the following steps:

[0024] Preparation step S1100: Prepare 120ml of licorice liquid extract, 180ml of compound camphor tincture, 120ml of glycerin, 1.67ml of concentrated ammonia water, 5g of guaifenesin, 1.9-2.3g of vitamin C, and an appropriate amount of purified water;

[0025] Sample preparation step S1200: respectively dissolving the guaifenesin and vitamin C in purified water to form a guaifenesin solution and a vitamin C solution;

[0026] Primary mixing step S1300: mix licorice liquid extract and glycerin evenly, add 500ml of purified water to dilute, then add concentrated ammonia water to adjust the pH value to 8-9 to obtain a primary mixed solution;

[0027] Secondary mixin...

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Abstract

The invention discloses a high-stability compound liquorice oral solution which contains vitamin C. The invention also discloses a preparation method of the high-stability compound liquorice oral solution. Vitamin C added into the compound liquorice oral solution disclosed by the invention can play a role of a stabilizer and takes a very good protection effect of maintaining the pH value of the solution and preventing oxidation of the main active ingredient morphine in a sample so that the product quality is more stable.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, in particular to a compound licorice oral solution with greatly improved stability and a preparation method thereof. Background technique [0002] Compound licorice oral solution is an expectorant and antitussive drug recorded in the Chinese Pharmacopoeia. Each 1000ml contains 120ml of licorice liquid extract, 180ml of compound camphor tincture, 120ml of glycerin, 5g of guaiacol glyceryl ether, concentrated ammonia solution and appropriate amount of water. Licorice liquid extract in the prescription is a protective expectorant; compound camphor tincture is an antitussive; guaiacol glycerol is an expectorant and antitussive; and it has a certain antiseptic effect. Glycerin and concentrated ammonia solution are used as auxiliary materials, which can keep the preparation stable and prevent the formation and precipitation of precipitates. Content requirements: every 1ml of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57A61K36/484A61K47/22A61K9/08A61P11/10A61P11/14A61K31/125A61K31/09A61K31/485
Inventor 叶全元王伟
Owner 北京海德润医药集团有限公司
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