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A soft tissue repair patch and preparation method thereof

A soft tissue and patch technology, applied in fabric surface trimming, non-woven fabrics, textiles and papermaking, etc., can solve problems such as poor long-term stability, excessive cell growth, and easy deformation, to strengthen the bonding force and optimize fiber orientation The effects of arrangement and good cell ingrowth characteristics

Inactive Publication Date: 2017-04-12
MEDPRINSHENZHEN REGENERATIVEA MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Animal experiments show that changes in the pore size and porosity of the scaffold will cause the repair effect of the scaffold material to deviate from expectations
Just like the technologies disclosed in the inventor’s previous two patents, although the patch has better bulkiness and softness, its long-term stability is poor, it is prone to deformation, and it is prone to excessive cell growth, which brings new problems such as hyperplasia.

Method used

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  • A soft tissue repair patch and preparation method thereof
  • A soft tissue repair patch and preparation method thereof
  • A soft tissue repair patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] (1) Dissolve L-polylactic acid (PLLA) in a mixed solvent of dichloromethane / 1,4-dioxane with a volume ratio of 4:6, so that the concentration of PLLA in the solution is 6g / 100mL;

[0085] (2) Put the fiber filament material solution obtained in step (1) into the electrospinning syringe, adjust the speed of the micro-injection pump to 2 ml / h, adjust the voltage of the high-voltage generator to 15 KV, and adjust the receiving device to receive The distance is 15 cm, electrospinning is carried out to obtain fibers, and the fibers are received into a film-like structure, and the electrospinning is turned off after spinning until the thickness of the film layer is about 0.5 mm to obtain a fiber film.

[0086] (3) The above-mentioned electrospun materials are used in a molding machine, the temperature is set at room temperature, the pressure is 0.1Mpa, and the pressurization time is 20s. After cold pressing, put it into a blast drying oven with a temperature of 45°C. After d...

Embodiment 2

[0088] (1) Dissolve polyvinylidene fluoride (PVDF) in a mixed solvent of N,N-dimethylformamide / acetone with a volume ratio of 4:6, so that the concentration of PVDF in the solution is 15g / 100mL;

[0089] (2) Put the fiber filament material solution obtained in step (1) into the electrospinning syringe, adjust the speed of the micro-injection pump to 4 ml / h, adjust the voltage of the high-voltage generator to 30 KV, and adjust the receiving device to receive The distance is 25 cm, electrospinning is carried out to obtain fibers, and the fibers are received into a film-like structure, and the electrospinning is turned off after spinning until the thickness of the film layer is about 0.5 mm to obtain a fiber film.

[0090] (3) The above-mentioned electrospun materials are used in a molding press, the temperature is set at 60°C, the pressure is 0.4Mpa, and the heating and pressing time is 20s. After hot pressing, put it into a blast drying oven with a temperature of 60°C. Take it...

Embodiment 3

[0092] (1) Dissolve polyvinylidene fluoride (PVDF) in a mixed solvent of dimethylacetamide / isophorone with a volume ratio of 4:6, so that the concentration of PVDF in the solution is 15g / 100mL;

[0093] (2) Put the fiber filament material solution obtained in step (1) into the electrospinning syringe, adjust the speed of the micro-injection pump to 4 ml / h, adjust the voltage of the high-voltage generator to 30 KV, and adjust the receiving device to receive The distance is 25 cm, electrospinning is carried out to obtain fibers, and the fibers are received into a film-like structure, and the electrospinning is turned off after spinning until the thickness of the film layer is about 0.5 mm to obtain a fiber film.

[0094] (3) The above-mentioned electrospun materials are used in a molding press, the temperature is set at 70°C, the pressure is 0.8Mpa, and the heating and pressing time is 20s. After hot-pressing, put it into a blast drying at a temperature of 60°C. Take it out after...

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Abstract

The invention discloses a soft tissue repairing patch and a preparation method thereof. The soft tissue repairing patch is a fiber scaffold consisting of fibers with the diameter of 0.01-10 microns, has a porous structure, and has a filling power of 200-2000cm<3> / g, and fiber junctions of the soft tissue repairing patch are subjected to fusion to form fiber nodes, wherein the fiber nodes formed at the fiber junctions by virtue of fusion are micro nodes formed at cross overlapped parts among fibers by virtue of fusion or macro nodes formed at side-by-side contact parts among the fibers by virtue of fusion. The preparation method of the soft tissue repairing patch comprises the steps for forming the fiber nodes by virtue of fusion. The soft tissue repairing patch provided by the invention has an appropriate filling power, is beneficial for fast adhesion and propagation of cells and tissues, conduction of cell differentiation and close lamination among tissues, and meanwhile keeps the pore size and the porosity stable during long-term in vivo long-dated fusion and evolution.

Description

technical field [0001] The invention belongs to the field of tissue engineering scaffolds, and relates to a soft tissue repair patch and a preparation method thereof, and more particularly relates to a repair patch applied to various hernias, pelvic floor, urinary incontinence and other soft tissues and a preparation method thereof. Background technique [0002] Electrospinning technology, as an effective technology for preparing tissue engineering scaffolds, is a research hotspot in the field of tissue repair and has outstanding application prospects. Electrospinning is a simple and effective processing method for preparing polymer ultrafine fibers. The ultrafine fibers prepared by this method can reach the nanometer scale, and the nano-bionic scaffolds can effectively simulate the natural extracellular matrix to a certain extent. The structure provides a more suitable microenvironment for cell growth and climbing. Due to this characteristic, the nanofiber membrane materia...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/50A61L27/18A61L27/16D04H1/728D06C7/02
Inventor 王国帅徐弢袁玉宇
Owner MEDPRINSHENZHEN REGENERATIVEA MEDICAL TECH CO LTD