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Extraction method and application of volatile oil in Prunella vulgaris for preventing and treating gynecological inflammation

An extraction method, a technology of gynecological inflammation, applied in the field of extraction of volatile oil from Prunella vulgaris, can solve problems such as unreported volatile oil gynecological diseases, achieve good economic and environmental benefits, improve extraction efficiency, and shorten extraction time

Inactive Publication Date: 2017-06-20
湖南佳霖干细胞科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Although Prunella vulgaris has been used as a medicine for a long time, the reports are mainly the pharmacological effects of the water extract and ethanol extract of Prunella vulgaris, but there is no report on the extraction of its volatile oil and its use in the treatment of gynecological diseases, such as chronic pelvic inflammatory disease, Cervicitis, mastitis, etc.

Method used

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  • Extraction method and application of volatile oil in Prunella vulgaris for preventing and treating gynecological inflammation
  • Extraction method and application of volatile oil in Prunella vulgaris for preventing and treating gynecological inflammation
  • Extraction method and application of volatile oil in Prunella vulgaris for preventing and treating gynecological inflammation

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Embodiment 1

[0024] This embodiment relates to a method for extracting volatile oil in Prunella vulgaris, and the specific steps are as follows:

[0025] 1. Weigh 500g of 40-mesh Prunella vulgaris powder with an electronic balance, add 100% methanol solution 8 times its mass, mix well, use ultrasonic extraction, ultrasonic power is 1000W, continuous extraction for 40min, filter, collect the filtrate, in the same Continuously extract 3 times, combine the filtrate, filter the combined filtrate again and concentrate it into an extract with a water content of about 15%;

[0026] 2. Add 100-200 mesh silica gel to the extract at a mass ratio of 1:1 and stir evenly. Put the well-stirred mixture into a silica gel column and rinse it with petroleum ether. The flow rate of petroleum ether is 40mL / min. The color of petroleum ether is close to colorless, and the washing liquid is obtained, and the petroleum ether is evaporated to dryness, and the yield of volatile oil of Prunella vulgaris is 3.32‰.

...

Embodiment 2

[0029] This embodiment relates to a method for extracting volatile oil in Prunella vulgaris, and the specific steps are as follows:

[0030] 1. Weigh 500g of 40-mesh Prunella vulgaris fruit powder with an electronic balance, add 60% methanol solution 10 times its mass, mix well, use ultrasonic extraction, ultrasonic power is 900W, continuous extraction for 60min, filter, collect the filtrate, under the same conditions extract continuously for 3 times, combine the filtrate, filter the combined filtrate again and concentrate it into an extract with a water content of about 18%;

[0031] 2. Add 100-200 mesh silica gel to the extract at a mass ratio of 1:1.5 and stir evenly. Put the well-stirred mixture into a silica gel column and wash it with petroleum ether. The flow rate of petroleum ether is 50mL / min. The color of the ether is colorless, and the rinse solution is obtained, and the petroleum ether is evaporated to dryness, and the yield of the volatile oil of Prunella vulgaris...

Embodiment 3

[0033] This embodiment relates to a method for extracting volatile oil in Prunella vulgaris, and the specific steps are as follows:

[0034] 1. Weigh 500g of 20-mesh Prunella vulgaris fruit powder with an electronic balance, add 9 times its mass in 90% ethanol solution, use ultrasonic extraction, ultrasonic power is 950W, continuous extraction for 50min, filter, collect filtrate, continuous extraction under the same conditions Three times, the filtrates were combined, and the combined filtrate was filtered again and concentrated into an extract with a water content of about 20%.

[0035] 2. Add 100-200 mesh silica gel to the extract at a mass ratio of 1:2 and stir evenly. Put the well-stirred mixture into a silica gel column and wash it with petroleum ether. The flow rate of petroleum ether is 70mL / min. The color of the ether was colorless, and the flushing solution was obtained, and the petroleum ether was evaporated to dryness, and the yield of the volatile oil of Prunella v...

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Abstract

The invention relates to a method for extracting volatile oil for preventing and treating gynecologic inflammation from self-heal, which comprises the following steps: 1) weighing self-heal raceme powder, adding 8-10 times by mass of methanol or ethanol solution as an extracting solution, extracting by an ultrasonic process, filtering, collecting the filtrate, repeatedly extracting 2-4 times, merging the filtrates, filtering the merged filtrate, and concentrating to obtain an extractum with the water content of 15-20%; and 2) mixing 100-200-mesh silica gel with the extractum, stirring uniformly, adding the uniform mixture into a silica gel column, flushing with petroleum ether, collecting the flushing fluid, and volatilizing petroleum ether to obtain the self-heal volatile oil. The method is high in extraction yield and easy to implement; and the extracted volatile oil has favorable drug effect and is suitable for wide popularization.

Description

technical field [0001] The invention belongs to the field of oil extraction, in particular to the extraction of volatile oil from Prunella vulgaris. Background technique [0002] Prunella vulgaris is the dried ear of Prunella vulgaris L., a plant of the Labiatae family. In my country, Prunella vulgaris is concentrated in the Huaihe River Basin and the middle and lower reaches of the Yangtze River. The wild resources in Jiangsu, Anhui, Zhejiang and Henan are the most abundant. ; In addition, South Korea, Japan, Ukraine and Kashmir are also distributed. The main components of Prunella vulgaris are triterpenes and their saponins, phenolic acids, sterols and their glycosides, flavonoids, coumarins, organic acids, volatile oils and sugars. [0003] Prunella vulgaris has a long history of medicinal use. Its main effects include clearing the liver and purging fire, improving eyesight, dissipating stagnation and reducing swelling; Carbuncle, breast addiction, distending pain in the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C11B9/02A61K36/536A61P15/00
Inventor 林丽美夏伯候廖端芳
Owner 湖南佳霖干细胞科技有限公司
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