Mycobacterium tuberculosis combined antigen for diagnosing pulmonary tuberculosis

An antigen and application technology, applied in disease diagnosis, analytical materials, biological material analysis, etc., can solve the problem that tuberculosis patients are difficult to achieve diagnostic results
CN104678097AActive Publication Date: 2015-06-03ACADEMY OF MILITARY MEDICAL SCI +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ACADEMY OF MILITARY MEDICAL SCI
Publication Date
2015-06-03

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Abstract

The invention provides a combined antigen comprising three mycobacterium tuberculosis antigens and an application of the combined antigen to preparation of a reagent for diagnosing active tuberculosis. The combined antigen comprises Rv3871, Rv3876 and Rv3879. Corresponding antibody detection methods are established by the aid of the three antigens and used for detecting corresponding antibody levels in biological samples, and the three detected antibody levels are particularly higher in sputum smear negative / sputum culture positive tuberculosis patients. A pulmonary tuberculosis diagnosing method is established by the aid of the combined antigen, and a positive sample is defined in such a manner that antibody levels corresponding to two or more antigens reach a positive judgment value. Verification of a lot of clinical samples indicates that the diagnosing method has the high sensitivity and the high specificity for sputum smear positive / sputum culture positive, sputum smear negative / sputum culture positive and sputum smear negative / sputum culture negative tuberculosis patients.
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Description

technical field

[0001] The invention relates to the field of immunodiagnosis, especially the field of diagnosis of active pulmonary tuberculosis. Background technique

[0002] Tuberculosis is still one of the major diseases that seriously threaten human health today. According to the data reported by the World Health Organization (WHO) in 2013, in 2012 alone, there were about 8.6 million new cases of tuberculosis in the world, and about 1.3 million deaths due to ZC nuclear disease. The prevention and control of tuberculosis remains a major challenge facing the world.

[0003] Early and rapid tuberculosis diagnosis methods are of great significance for the prevention and control of tuberculosis. Currently, researchers have developed a variety of methods for TB diagnosis, including tuberculin skin test, sputum smear, sputum culture, and PCR. These methods have made a certain contribution to the prevention and control of tuberculosis. However, current diagnostic methods sti...

Claims

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