A kind of composite material for preparing intraocular lens and its application

A technology of intraocular lens and composite materials, applied in the direction of intraocular lens, eye implant, etc., can solve the problems that cannot be fully satisfied, prone to crease scratches, secondary cataracts, etc., and can be easily bent, folded and pushed Implantation, good medical application value, and stable performance

Active Publication Date: 2018-01-16
四川兴泰普乐医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of the above-mentioned soft materials is a great progress in the field of IOL, which has significantly improved the comfort and prognosis of patients. However, these materials still cannot fully meet the requirements of IOL materials, and there are more or less certain limitations. insufficient
Specifically, the advantages and disadvantages of various soft materials are as follows: (1) Hydrophilic polyacrylate materials have good biocompatibility, are not easy to adhere to, and are not easy to adhere to bacteria, but due to their hydrophilic nature, intraocular metabolites It is easy to gather in it, causing secondary cataract; (2) Hydrophobic acrylate has high diopter, good toughness, and overall hydrophobicity, so it will not cause metabolites to gather, but it is easy to adhere, and creases and scratches are prone to occur during implantation; (3) )Silicone gel material is heat-resistant and aging-resistant, not easy to stick, and can be clamped repeatedly without being scratched, but has low diopter, poor toughness, and turbidity due to intraocular metabolites

Method used

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  • A kind of composite material for preparing intraocular lens and its application
  • A kind of composite material for preparing intraocular lens and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Octamethylcyclotetrasiloxane 50mg, Hexamethylhexavinylcyclohexasiloxane 5mg, Ethyl Acrylate 300mg, Phenylethyl Methacrylate 500mg, Trifluoroethyl Methacrylate 150mg, Azobisiso Butyronitrile 3mg, ethylene glycol dimethacrylate 5mg, UV-32012mg.

[0034] Mix the above components and carry out degassing treatment, put them into a flat mold and place them in a water bath at 80°C to react overnight, then transfer them to a heating furnace at 90°C to continue the reaction for 24 hours, then take them out, cool and demould, and then use isopropyl Alcohol is used as a detergent, and the blank is washed by Soxhlet extraction for 18 hours, dried in vacuum and cut by freezing to obtain the final finished intraocular lens.

Embodiment 2

[0036]Octamethylcyclotetrasiloxane 100mg, Tetramethyldivinyldisiloxane 20mg, Ethyl Acrylate 250mg, Phenylethyl Methacrylate 500mg, Trifluoroethyl Methacrylate 100mg, Azobisisobutyl Nitrile 3 mg, ethylene glycol dimethacrylate 5 mg, UV-320 12 mg, yellow dye 30 mg.

[0037] Mix the above components and carry out degassing treatment, put them into a flat mold and react overnight in a 75°C water bath, then transfer to a 100°C heating furnace to continue the reaction for 20 hours, then take it out and cool it for demoulding, and then use isopropanol as a detergent , using the Soxhlet extraction method to wash the blank for 18 hours, vacuum drying, and then freezing and cutting to obtain the final intraocular lens product.

Embodiment 3

[0039] Hexamethylcyclotrisiloxane 100mg, Trimethyltrivinylcyclotrisiloxane 10mg, n-butyl acrylate 200mg, methyl methacrylate 400mg, trifluoroethyl acrylate 120mg, azobisisobutyronitrile 5mg , propylene glycol dimethacrylate 10mg, UV-320 15mg, collagen source protein 50mg.

[0040] Mix the above components and carry out degassing treatment, put them into a flat mold and react in a water bath at 60°C overnight, then transfer to a heating furnace at 80°C to continue the reaction for 30 hours, then take it out, cool and demould, and then use isopropanol as a detergent , using the Soxhlet extraction method to wash the blank for 18 hours to obtain the final intraocular lens product.

[0041] Table 1 lists the basic performance indexes of the composite materials obtained in the above three examples, and compared with an imported intraocular lens product as a control. It can be seen that the tensile strength and modulus of the IOL products made of silicone gel-polymethacrylate compos...

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Abstract

The invention relates to a composite material for preparing an intraocular lens and a preparation method thereof, belonging to the field of polymer materials and applications thereof. The composite material includes the following raw materials: cyclomethicone, polyvinyl silicone oil, hydrophobic acrylate, hydrophobic methacrylate, fluorine-substituted (meth)acrylate, hydrophilic (meth)acrylate, initiator agents, crosslinkers and UV absorbers. After the above components are mixed in proportion, they are injected into a mold to complete pre-polymerization, then cross-linked and solidified, cooled and demoulded, and after removing residual monomers, vacuum-dried to obtain a composite material for preparing an intraocular lens. The intraocular lens made of the composite material provided by the invention has good toughness, is not easy to stick and scratch, and is suitable for surgical incisions of ≤2.0mm; the refractive index is high, greater than 1.50; the coefficient of friction is low, and it avoids blockage in the injector, and has the advantages of Excellent medical application value.

Description

technical field [0001] The invention relates to the field of polymer materials and their applications, in particular to a composite material for preparing intraocular lenses, a preparation method and applications thereof. Background technique [0002] Cataracts are the leading cause of blindness and the only cure for cataracts is surgery to remove the cloudy lens and implant an intraocular lens (IOL). Since the first polymethyl methacrylate (PMMA) IOL appeared in the world in 1949, IOL implantation has become a routine means of treating cataract. Due to its excellent biocompatibility and optical properties, PMMA was first used in IOLs, but its material is too hard to be folded, requiring a large surgical incision, usually 5-7mm, and the patient’s recovery time is longer. The comfort is poor, and operations such as sutures are likely to cause surgically induced astigmatism, so they are gradually being replaced by other materials. [0003] In order to achieve better therapeu...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): C08F220/18C08F220/14C08F220/22C08F222/14C08L33/10C08L33/12C08L83/04C08L83/07A61F2/16
Inventor辛剑宇杨立宝王磊磊
Owner四川兴泰普乐医疗科技有限公司