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A kind of low-hardness medical thermoplastic bromobutyl rubber and preparation method thereof

A brominated butyl rubber and thermoplastic technology, which is applied in the field of low hardness medical thermoplastic brominated butyl rubber and its preparation, can solve the problems of inability to prepare hard thermoplastic elastomer materials, inability to achieve better phase inversion, dynamic vulcanizate properties To achieve the effect of simple and clean material composition, lower product cost, and lower energy consumption

Active Publication Date: 2017-05-24
SHANDONG DAWN POLYMER CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the hardness range of rubber stoppers used in pharmaceutical packaging is mainly low-hardness elastomer materials between Shore A 35-50. The traditional dynamic vulcanization technology has certain limitations: the proportion of the rubber phase including oil filling should not be too high , while a low rubber-to-plastic ratio can only produce materials with medium hardness (Shore A 50-80) (such as the invention patent application number 201210007746.6), and a high rubber-to-plastic ratio cannot achieve phase inversion well, and the resulting dynamic The performance of the vulcanizate is very poor, and it is impossible to prepare a thermoplastic elastomer material with a low hardness that meets the requirements of medical packaging. The invention adopts a two-step dynamic vulcanization process innovatively, and blends the prepared thermoplastic dynamic vulcanizate into the rubber again as a new continuous phase. phase and its coordination system, through two-step dynamic vulcanization to achieve the purpose of increasing the rubber-to-plastic ratio and the amount of oil, so as to successfully prepare low-hardness thermoplastic bromobutyl rubber that meets the requirements for use in medical packaging materials

Method used

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  • A kind of low-hardness medical thermoplastic bromobutyl rubber and preparation method thereof
  • A kind of low-hardness medical thermoplastic bromobutyl rubber and preparation method thereof
  • A kind of low-hardness medical thermoplastic bromobutyl rubber and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: (the part described in embodiment and comparative example is mass part)

[0033]Mix 60 parts of bromobutyl rubber and 50 parts of polypropylene in an internal mixer at 180°C, and gradually add 60 parts of mineral oil; add 2.2 parts of the prepared rubber-plastic blend to an internal mixer at 20-70°C Phenolic resin HY-2045 and 0.7 parts of zinc oxide are evenly mixed, and then the flakes are discharged on the twin-roll mill, and are forced to be fed into the twin-screw extruder, where dynamic cross-linking is performed, and each section of the screw / machine is set The head temperature is 160, 165, 170, 175, 180, 185, 185, 185, 185, 185, 185, 185 / 185°C, the speed is 400rpm, dynamic vulcanization is carried out, and small molecules are vacuumed out at the same time, extruded and granulated to obtain hardness Higher thermoplastic bromobutyl rubber bead intermediate.

[0034] Add 1.4 parts of phenolic resin HY-2045 and 0.5 parts of zinc oxide to the remaining ...

Embodiment 2

[0036] Mix 60 parts of bromobutyl rubber and 33.3 parts of polypropylene in an internal mixer at 180°C, and gradually add 50 parts of mineral oil; add 1 part of the prepared rubber-plastic blend to an internal mixer at 20-70°C The phenolic resin HY-2045 and 0.5 part of zinc oxide are evenly mixed, and then the sheets are produced on a double-roll mill, and the first step of the dynamic vulcanization process is the same as in Example 1.

[0037] Add 0.6 parts of phenolic resin HY-2045 and 0.3 parts of zinc oxide to the remaining part of bromobutyl rubber and 30 parts of mineral oil, mix evenly on an open mill, granulate and mix evenly with intermediate granules, and then proceed to the second step Dynamic vulcanization, process parameters and flow process are the same as embodiment 1.

Embodiment 3

[0039] Mix 60 parts of bromobutyl rubber and 20 parts of polypropylene in an internal mixer at 180°C, and gradually add 40 parts of mineral oil; add 0.5 parts of the prepared rubber-plastic blend to an internal mixer at 20-70°C HVA-2 and 0.3 parts of zinc oxide are uniformly mixed, and then flakes are produced on a double-roll mill, and the first step of dynamic vulcanization process parameters and process are the same as in Example 1.

[0040] Add 0.3 parts of HVA-2 and 0.1 parts of zinc oxide to the remaining part of bromobutyl rubber and 20 parts of mineral oil, mix evenly on the open mill, granulate and mix evenly with intermediate particles, the second step is dynamic vulcanization, process Parameters and flow process are the same as embodiment 1.

[0041] Table 1

[0042]

[0043] Performance

[0044]

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Abstract

The invention provides low-hardness medical thermoplastic brominated butyl rubber and a preparation method thereof, and belongs to the technical field of polymer materials. The low-hardness medical thermoplastic brominated butyl rubber is prepared from a rubber-plastic blend of brominated butyl rubber and polypropylene by a complete pre-dispersion two-step method and dynamic vulcanization technology, can be thermoplastically processed and has the application performance of thermoplastic brominated butyl rubber, the material composition is simple, clean and sulfur-free, or antioxidant or stabilizer is added, the safety and sealing property of an elastomer material in pharmaceutical package application, the low-hardness medical thermoplastic brominated butyl rubber can be directly injection molded into gaskets of rubber plugs, combined covers and infusion bags (bottles), the production process is cleaner, the energy consumption is greatly reduced, and the product cost is greatly reduced.

Description

technical field [0001] The invention relates to a low-hardness medical thermoplastic brominated butyl rubber and a preparation method thereof, belonging to the technical field of polymer materials. Background technique [0002] As people pay more attention to the impact of drug packaging materials on drug storage, use safety and stability, the supervision of the State Food and Drug Administration has been strengthened, and the raw materials of medical rubber stoppers have changed from natural rubber in the early stage to gradual replacement after 2000. It is halogenated butyl rubber, because of the excellent elasticity and sealing performance of butyl rubber plugs, stable chemical properties, especially the less amount of vulcanizing agent used in halogenated butyl rubber, excellent product sealing, and biological indicators such as hemolysis, heat source, and acute toxicity It meets the requirements for medical use. In 2004, my country's medical rubber stoppers enforced "buty...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L23/28C08L23/12C08L91/00B29B9/06
CPCC08L23/283C08L2205/02C08L2205/035C08L23/12C08L91/00C08L61/06C08K2003/2296
Inventor 田洪池张世甲韩吉斌陈文泉刘晓平蒿文朋
Owner SHANDONG DAWN POLYMER CO LTD
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