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Urea micro-capsule preparation and preparation method thereof

A technology of urea and microcapsules, which is applied in the field of urea microcapsule preparations and its preparation, can solve the problems of urea intracranial pressure rebound, limit the medical application of urea, and unstable properties of urea, so as to reduce side effects and enhance the therapeutic effect , Avoid the effect of peak and valley phenomenon

Active Publication Date: 2015-07-08
SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the side effects of urea (increased brain volume and rebound intracranial pressure after medication) and the instability of urea properties, the medical application of urea is greatly limited, and urea alone is generally not selected clinically.

Method used

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  • Urea micro-capsule preparation and preparation method thereof
  • Urea micro-capsule preparation and preparation method thereof
  • Urea micro-capsule preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation of embodiment 1 urea microcapsule tablet of the present invention

[0032]

[0033] Preparation Process:

[0034] ① Pass the prescribed amount of urea through a 60-120-mesh sieve, place it in a fluidized bed, pass hot air into it to suspend and fluidize it, and the temperature of the hot air is 45-55°C;

[0035] ② Dissolve gelatin and hydroxyethyl cellulose with an appropriate amount of 70% ethanol aqueous solution to make a 15% capsule material solution. The capsule material solution is atomized through the nozzle of the fluidized bed and continuously added to the fluidized bed, where the atomization pressure is 0.25-0.30 Mpa, the spraying speed is 50-60rpm, after the solution is sprayed, continue to enter the air and dry until the moisture is less than 2%, stop heating, cool and discharge, and obtain urea microcapsules for use;

[0036] ③ Mix the prepared urea microcapsules with the prescribed amount of croscarmellose sodium, micropowder silica gel...

Embodiment 2

[0037] Embodiment 2 The preparation of urea microcapsule tablet of the present invention

[0038]

[0039] Preparation Process:

[0040] ① Pass the prescribed amount of urea through a 60-120-mesh sieve, place it in a fluidized bed, pass hot air into it to suspend and fluidize it, and the temperature of the hot air is 45-55°C;

[0041] ②Dissolve polyethylene glycol and carboxymethyl cellulose with an appropriate amount of 70% ethanol aqueous solution to make a 15% capsule material solution, and the capsule material solution is atomized through the nozzle of the fluidized bed and continuously added to the fluidized bed, wherein the atomization pressure is 0.25-0.30Mpa, the spraying speed is 50-60rpm, after the solution is sprayed, continue to enter the air and dry until the water content is less than 2%, stop heating, cool and discharge, and obtain urea microcapsules for use;

[0042] ③ Mix the prepared urea microcapsules with the prescribed amount of pregelatinized starch a...

Embodiment 3

[0043] Embodiment 3 The preparation of urea microcapsule tablet of the present invention

[0044]

[0045]

[0046] Preparation Process:

[0047] ① Pass the prescribed amount of urea through a 60-120-mesh sieve, place it in a fluidized bed, pass hot air into it to suspend and fluidize it, and the temperature of the hot air is 45-55°C;

[0048] ② Dissolve polyvinylpyrrolidone and hydroxypropyl cellulose with an appropriate amount of 70% ethanol aqueous solution to make a 15% capsule material solution, and the capsule material solution is atomized through the nozzle of the fluidized bed and continuously added to the fluidized bed, where the atomization pressure is 0.25 ~0.30Mpa, the spraying speed is 50~60rpm, after the solution is sprayed, continue to enter the air and dry until the water content is less than 2%, stop heating, cool and discharge, and obtain urea microcapsules for use;

[0049] ③ Mix the prepared urea microcapsules with the prescribed amount of croscarmel...

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Abstract

The invention belongs to the technical field of medicinal preparations, relates to a preparation of a dehydrating and dieresis-inducing drug, in particular to a urea micro-capsule preparation and a preparation method thereof. A main drug urea is taken as a capsule core material, a capsule material is added to prepare a urea micro-capsule, and then, the urea micro-capsule is uniformly mixed with other auxiliaries to prepare the urea micro-capsule preparation according to a normal technology. The micro-capsule preparation can be used for remarkably improving the stability of urea, and is more suitable for industrial large-scale production. The preparation produced by the method disclosed by the invention can be used for enabling the drugs to quickly release in body to bring the dehydrating and dieresis-inducing effects of the urea into play better. Meanwhile, the abnormal smell of the urea can be covered, so that the compliance of the patient is increased.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a preparation of urea, a dehydrating and diuretic drug, in particular to a urea microcapsule preparation and a preparation method thereof. technical background [0002] Cerebral edema refers to the pathological phenomenon that the increase of water in the brain leads to the increase of brain volume, and it is the response of brain tissue to various pathogenic factors. If it is not diagnosed and treated in time, the cerebral edema will increase, or develop from localized to diffuse, which will cause serious damage to the brain, form irreversible secondary pathological changes, and cause brain death. This outcome is due to general damage to the brain tissue and severe damage to the brainstem secondary to brain herniation. [0003] The degree and duration of cerebral edema have a significant impact on the outcome and prognosis of the disease, and should be treated...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K31/17A61P7/10A61P25/00
Inventor 王春艳李志滨靳志秀王军
Owner SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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