Traditional Chinese medicinal composition for treating nephropathy as well as preparation method and detection method thereof

A detection method and composition technology, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems that quality control methods are not included in quantitative detection, active ingredients are not fully utilized, and cannot respond well Preparation quality and other issues

Inactive Publication Date: 2015-07-08
云南雷允上理想药业有限公司
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

In order to ensure that high-quality Shenshuaining Chinese medicines for the treatment of kidney diseases are used for treatment, and make them fully effective in clinical practice, so that patients can recover as soon as possible, the preparation method and quality control of such medicines are very important, and the existing The preparation method of the drug Shenshuaining for the treatment of nephropathy, the active ingredients of the monarch drug rhubarb and Coptis chinensis have not been fully utilized, and its quality control metho

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  • Traditional Chinese medicinal composition for treating nephropathy as well as preparation method and detection method thereof
  • Traditional Chinese medicinal composition for treating nephropathy as well as preparation method and detection method thereof
  • Traditional Chinese medicinal composition for treating nephropathy as well as preparation method and detection method thereof

Examples

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Example Embodiment

[0050] Example 1

[0051] Weigh the raw materials (g) according to the following proportion: 400g of rhubarb, 250g of wild ginseng, 100g of coptis, 250g of pinellia ternata, 100g of tangerine peel, 200g of poria, 700g of salvia, 200g of achyranthes, 100g of safflower, 100g of licorice.

[0052] The preparation method is as follows:

[0053] (1) Crush 200g of rhubarb, which is half of the mass of each crude drug, into rhubarb powder for later use. The remaining 200g of rhubarb is impregnated with ethanol, then slowly percolated, and the resulting percolate is collected for later use; Weigh the eight herbs of Radix Pseudostellariae, Pinellia ternata, dried tangerine peel, Poria, Salvia miltiorrhiza, Achyranthes bidentata, safflower and licorice, and collect the resulting decoction for later use; decoct the weighed Rhizoma Coptidis in water, and collect the proceeds Decoction for use;

[0054] (2) The medicine powder and percolation liquid of the raw material medicine obtained in step (...

Example Embodiment

[0057] Example 2

[0058] Weigh the raw materials (g) according to the following ratio: 400g of rhubarb, 250g of radix ginseng, 100g of coptis, 250g of Pinellia ternata, 100g of tangerine peel, 200g of Poria cocos, 700g of salvia, 700g of Achyranthes bidentata, 100g of safflower, 100g of licorice; basic preparation method Same as Example 1, except that: in the 200g rhubarb immersion extraction in step (1), the following method is adopted: 200g rhubarb is first immersed in ethanol with a mass percentage of 30% to 60%, and the immersion time is 40%. After the immersion, the rhubarb and its immersion liquid are heated and refluxed for extraction at a heating temperature of 85-95°C, and the extraction time is 1.5-2.5 hours. Collect the obtained extract and put the obtained extract at 90-95°C. Concentrated to a relative density of 1.25~1.30g / cm 3 Thick paste.

[0059] In the above examples, the treatment method of rhubarb can more fully activate the effective ingredients in the raw mat...

Example Embodiment

[0060] Example 3

[0061] Weigh the raw materials (g) according to the following proportions: 350g of rhubarb, 200g of Radix ginseng, 70g of Coptis, 230g of Pinellia ternata, 90g of tangerine peel, 190g of Poria cocos, 670g of salvia, 190g of Achyranthes bidentata, 80g of safflower, 85g of licorice; basic preparation method And the method of administration is the same as in Example 1.

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Abstract

The invention relates to a traditional Chinese medicinal composition for treating nephropathy as well as a preparation method and a detection method thereof. The traditional Chinese medicinal composition is prepared from the following raw materials: rheum officinale, radix pseudostellariae, coptis chinensis, rhizoma pinellinae praeparata, dried orange peel, poria cocos, salvia miltiorrhiza, radix achyranthis bidentatae, safflower and liquorice root by combining water extraction and alcohol extraction, and stability and mass content detection is carried out. According to the invention, the classic formula of existing Shenshuaining is researched and improved, so that the full extraction and effect development of active ingredients in the raw materials are achieved, the relative dosage of patients is reduced, and the preparation method is simple, convenient and easy in operation; in the detection method, the content determination of the rheum officinale which serves as a monarch drug and the salvia miltiorrhiza which functions as a ministerial drug is added, high performance liquid chromatography for the simultaneous determination of the contents of active ingredients of the rheum officinale and the salvia miltiorrhiza is established, and the detection method can be used for the convenient and efficient qualitative and quantitative determination of the contents of active ingredients in the traditional Chinese medicinal composition for treating nephropathy, so as to objectively, comprehensively and accurately evaluate the mass of Shenshuaining-like drugs; and the detection method has significance in controlling the quality of the Shenshuaining-like drugs and guaranteeing the curative effect.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating nephropathy, a preparation method and a detection method thereof. Background technique [0002] Kidney diseases such as renal failure are common serious diseases in clinical practice. Dialysis and kidney transplantation are usually used for treatment. However, the medical expenses are too high, and the general family cannot afford it. Moreover, complications are likely to occur during dialysis treatment, and rejection is common after kidney transplantation. In this regard, patients and their families are generally more difficult to bear. The application of traditional Chinese medicine can effectively avoid the above situation, such as Shenshuaining Capsules, etc., which can effectively relieve symptoms and reduce the pain of patients, but in order to ensure a significant clinical effect, improvements ar...

Claims

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Application Information

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IPC IPC(8): A61K36/8888A61P13/12G01N30/02
Inventor 罗实罗红艳
Owner 云南雷允上理想药业有限公司
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