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Traditional Chinese medicinal composition for treating nephropathy as well as preparation method and detection method thereof

A detection method and composition technology, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems that quality control methods are not included in quantitative detection, active ingredients are not fully utilized, and cannot respond well Preparation quality and other issues

Inactive Publication Date: 2015-07-08
云南雷允上理想药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In order to ensure that high-quality Shenshuaining Chinese medicines for the treatment of kidney diseases are used for treatment, and make them fully effective in clinical practice, so that patients can recover as soon as possible, the preparation method and quality control of such medicines are very important, and the existing The preparation method of the drug Shenshuaining for the treatment of nephropathy, the active ingredients of the monarch drug rhubarb and Coptis chinensis have not been fully utilized, and its quality control method has not been included in the quantitative detection of the monarch drug rhubarb and ministerial drug Danshen, which cannot reflect the quality of the preparation well Therefore, in order to protect the interests of patients, it is necessary to study and design a method that can simultaneously determine the active ingredients in rhubarb aloe-emodin, rhein, emodin, chrysophanol, emodin methyl ether and salvia miltiorrhiza on the basis of existing technologies. The detection method of the content of danshensu sodium and salvianolic acid B

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  • Traditional Chinese medicinal composition for treating nephropathy as well as preparation method and detection method thereof
  • Traditional Chinese medicinal composition for treating nephropathy as well as preparation method and detection method thereof
  • Traditional Chinese medicinal composition for treating nephropathy as well as preparation method and detection method thereof

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Experimental program
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Effect test

Embodiment 1

[0051] Weigh raw materials (g) according to the following proportions: 400g rhubarb, 250g heterophylla, 100g coptis, 250g pinellia, 100g tangerine peel, 200g poria, 700g salvia, 200g achyranthes bidentata, 100g safflower, 100g licorice.

[0052] The preparation method is as follows:

[0053] (1) half of the said raw material rhubarb quality, i.e. 200g rhubarb, is pulverized into rhubarb powder for use, and the remaining 200g rhubarb is impregnated with ethanol first, and then slowly percolates, and the percolation liquid of the gained is collected for use; Decoct the weighed eight herbs of Pseudostellaria Pseudostellaria, Pinellia, Tangerine Peel, Poria, Danshen, Achyranthes bidentata, Safflower and Licorice, and collect the obtained decoction for later use; The decoction is ready for use;

[0054] (2) Mix uniformly the medicinal powder and percolation solution of the crude drug obtained in step (1), Bawei medicine and Coptis chinensis decoction to obtain the traditional Chin...

Embodiment 2

[0058]Weigh the raw materials (g) according to the following proportions: 400g rhubarb, 250g heterophylla, 100g coptis, 250g pinellia, 100g tangerine peel, 200g poria cocos, 700g salvia miltiorrhiza, 200g achyranthes bidentata, 100g safflower, 100g licorice; basic preparation method With embodiment 1, wherein, the difference is: in step (1) 200g rhubarb dipping extraction, adopt following method: 200g rhubarb is soaked with the ethanol that is 30%~60% with mass percent first, dipping time is 40 hour or more, then, the obtained rhubarb and its impregnating solution are heated and refluxed for extraction, the heating temperature is 85-95°C, the extraction time is 1.5-2.5 hours, the obtained extract is collected, and the obtained extract is placed at 90-95°C Concentrated to a relative density of 1.25-1.30g / cm 3 thick paste.

[0059] In the above example, the treatment method of rhubarb can fully activate the active ingredients in the raw materials, and the extraction rate reache...

Embodiment 3

[0061] Weigh raw materials (g) according to the following proportions: 350g rhubarb, 200g heterophylla, 70g coptis, 230g pinellia, 90g tangerine peel, 190g poria cocos, 670g salvia, 190g achyranthes bidentata, 80g safflower, 85g licorice; basic preparation method And taking method is with embodiment 1.

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Abstract

The invention relates to a traditional Chinese medicinal composition for treating nephropathy as well as a preparation method and a detection method thereof. The traditional Chinese medicinal composition is prepared from the following raw materials: rheum officinale, radix pseudostellariae, coptis chinensis, rhizoma pinellinae praeparata, dried orange peel, poria cocos, salvia miltiorrhiza, radix achyranthis bidentatae, safflower and liquorice root by combining water extraction and alcohol extraction, and stability and mass content detection is carried out. According to the invention, the classic formula of existing Shenshuaining is researched and improved, so that the full extraction and effect development of active ingredients in the raw materials are achieved, the relative dosage of patients is reduced, and the preparation method is simple, convenient and easy in operation; in the detection method, the content determination of the rheum officinale which serves as a monarch drug and the salvia miltiorrhiza which functions as a ministerial drug is added, high performance liquid chromatography for the simultaneous determination of the contents of active ingredients of the rheum officinale and the salvia miltiorrhiza is established, and the detection method can be used for the convenient and efficient qualitative and quantitative determination of the contents of active ingredients in the traditional Chinese medicinal composition for treating nephropathy, so as to objectively, comprehensively and accurately evaluate the mass of Shenshuaining-like drugs; and the detection method has significance in controlling the quality of the Shenshuaining-like drugs and guaranteeing the curative effect.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating nephropathy, a preparation method and a detection method thereof. Background technique [0002] Kidney diseases such as renal failure are common serious diseases in clinical practice. Dialysis and kidney transplantation are usually used for treatment. However, the medical expenses are too high, and the general family cannot afford it. Moreover, complications are likely to occur during dialysis treatment, and rejection is common after kidney transplantation. In this regard, patients and their families are generally more difficult to bear. The application of traditional Chinese medicine can effectively avoid the above situation, such as Shenshuaining Capsules, etc., which can effectively relieve symptoms and reduce the pain of patients, but in order to ensure a significant clinical effect, improvements ar...

Claims

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Application Information

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IPC IPC(8): A61K36/8888A61P13/12G01N30/02
Inventor 罗实罗红艳
Owner 云南雷允上理想药业有限公司
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