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Swine influenza hemagglutinin and neuraminidase variants

A technology of hemagglutinin and neuraminidase, which is applied in the field of swine influenza hemagglutinin and neuraminidase variants, can solve problems such as growth inhibition of human influenza virus

Inactive Publication Date: 2015-07-15
MEDIMMUNE LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, growth of human influenza viruses in chicken embryos as a substrate for generating influenza vaccine viruses is typically hampered by the virus's preference for binding to human receptors (as opposed to avian receptors)

Method used

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  • Swine influenza hemagglutinin and neuraminidase variants
  • Swine influenza hemagglutinin and neuraminidase variants
  • Swine influenza hemagglutinin and neuraminidase variants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment A1

[0110] Example A1. A recombinant influenza virus comprising a first genome segment encoding a hemagglutinin polypeptide, wherein the hemagglutinin polypeptide comprises as shown in SEQ ID NO: 1, SEQ ID NO: 3 or SEQ ID NO: 4 amino acid sequence.

Embodiment A2

[0111] Embodiment A2. The recombinant influenza virus of embodiment A1, wherein the hemagglutinin comprises the amino acid sequence as shown in SEQ ID NO:1.

Embodiment A3

[0112] Embodiment A3. The recombinant influenza virus as described in embodiment A2, wherein the hemagglutinin as shown in SEQ ID NO:1 comprises:

[0113] Aspartic acid at amino acid residue position 125; or

[0114] Glutamic acid at amino acid residue position 127; or

[0115] Glutamic acid at amino acid residue position 209; or

[0116] Aspartic acid at amino acid residue position 125 and glutamic acid at amino acid residue position 127; or

[0117] Aspartic acid at amino acid residue position 125 and glutamic acid at amino acid residue position 209; or

[0118] Glutamic acid at amino acid residue position 127 and glutamic acid at amino acid residue position 209; or

[0119] Aspartic acid at amino acid residue position 125, glutamic acid at amino acid residue position 127, and glutamic acid at amino acid residue position 209.

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Abstract

Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.

Description

Background of the invention [0001] Cross references to related applications [0002] This application claims priority to U.S. Application No. 61 / 727,213 filed on November 16, 2012. The disclosure of this provisional application is incorporated herein by reference in its entirety. Background of the invention [0003] The 2009 influenza pandemic caused by the swine-origin H1N1 influenza virus spread to more than 215 countries and caused at least 18,000 laboratory confirmed deaths (Garten et al., 2009, Science 325:197-201 , 31). In such a pandemic situation, rapid production of vaccines is critical. However, the growth of human influenza viruses in chicken embryos used as a substrate for influenza vaccine virus production is typically hindered by the virus' preference for binding to human receptors (relative to avian receptors). Therefore, egg adaptation is usually required to improve the growth of vaccine viruses in eggs (Gambaryan et al., 1989, pp. 175-218, in R. Krug (Editor) ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/145
CPCA61K2039/543A61K2039/5254C12N2760/16134A61K39/12A61P31/16A61K39/145A61K2039/70C12N7/00C12N2760/16121C12N2760/16221C12N2760/16234
Inventor 金红陈忠英
Owner MEDIMMUNE LLC
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