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A kind of composition for treating diarrhea of ​​livestock and poultry and preparation method thereof

A technology for livestock and poultry diarrhea and compositions, which is applied in the field of compositions and preparations for treating livestock and poultry diarrhea, can solve the problems of decreased drug sensitivity, decreased therapeutic effect, and excessive drug residues, and achieves reduction in frequency and dose of medication, and reduction in Chance of drug resistance, effects of intestinal fluid reduction

Active Publication Date: 2017-07-21
SICHUAN ANIMAL SCI ACAD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] During the use of drugs, bacteria develop drug resistance, which reduces their sensitivity to drugs, and the therapeutic effect of these drugs alone decreases, and some even have no therapeutic effect, and some may cause other diseases due to secondary infection
In order to achieve the purpose of treating diseases, farmers generally adopt the method of increasing the dosage of drugs or prolonging the use time, which leads to the problem of excessive drug residues

Method used

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  • A kind of composition for treating diarrhea of ​​livestock and poultry and preparation method thereof
  • A kind of composition for treating diarrhea of ​​livestock and poultry and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] in vitro susceptibility testing

[0036] 1. Materials

[0037] 1.1 Tested strains Escherichia coli and Salmonella were isolated, identified and preserved from the Sichuan Academy of Animal Husbandry Sciences from dead livestock and poultry.

[0038] 1.2 Test drugs Standard products of trimethoprim lactate, norfloxacin lactate, acemequin, and atropine sulfate were purchased from China Veterinary Drug Control Institute.

[0039] 1.3 M-H medium was purchased from Hangzhou Microbiological Reagent Co., Ltd.

[0040] 2. Method

[0041] 2.1 Preparation of test drugs

[0042] 2.1.1 A Norfloxacin Lactate Injection: Take 80ml of water for injection, heat it to boiling, cool to 80°C, add 10g of Norfloxacin Lactate (calculated as Norfloxacin), stir evenly to fully dissolve it, and then add Prescription amount of sodium bisulfite 0.2g, disodium edetate 0.01g, stir to dissolve; add water for injection to make up to 100ml, filter through membrane, potting, sterilize at 100°C for 3...

Embodiment 2

[0060] A preparation method for an injection for treating livestock and poultry diarrhea, comprising the following steps:

[0061] 1) Take 3ml of dimethyl sulfoxide, heat it properly, add 1g of acemethaquine and stir to dissolve.

[0062] 2) Heat 80ml of water for injection to boiling, cool to 80°C, add norfloxacin lactate 5g, trimethoprim lactate 2.5g, atropine 0.05g, sodium bisulfite 0.15g, edetate disodium 0.008 g, stir to dissolve.

[0063] 3) Add the solution prepared in step 1) into the solution prepared in step 2), stir evenly, make up to volume with water for injection, filter through a filter, pot the filtrate, and sterilize at 121°C and 0.15MPa for 15-20 minutes. The present invention relates to norfloxacin lactate injection for treating livestock and poultry diarrhea.

Embodiment 3

[0065] A preparation method for an injection for treating livestock and poultry diarrhea, comprising the following steps:

[0066] 1) Take 3.5ml of dimethyl sulfoxide, heat it properly, add 2g of acemethaquine and stir to dissolve.

[0067] 2) Take 80ml of water for injection, heat it to boiling, cool to 80°C, add 10g of norfloxacin lactate, 5g of trimethoprim lactate, 0.1g of atropine, 0.25g of sodium bisulfite, and 0.015g of disodium edetate , stir to dissolve.

[0068] 3) Add the solution prepared in step 1) into the solution prepared in step 2), stir evenly, make up to volume with water for injection, filter through a filter, pot the filtrate, and sterilize at 121°C and 0.15MPa for 15-20 minutes. The present invention relates to norfloxacin lactate injection for treating livestock and poultry diarrhea.

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Abstract

The invention relates to the field of veterinary medicine, in particular to a composition for treating livestock and poultry diarrhea and a preparation method thereof. A composition for treating livestock and poultry diarrhea mainly contains norfloxacin lactate and acemequine. The composition for treating livestock and poultry diarrhea provided by the present invention is mainly made of norfloxacin lactate and acemequine, and the synergistic cooperation between the two is enhanced, so that the combined use of norfloxacin lactate and acemequine has double effects , double antibacterial and bactericidal, reduce the probability of bacterial resistance, and increase the sensitivity of bacteria, quick effect on the treatment of livestock and poultry diarrhea, strong antibacterial effect, can prevent infection and secondary infection, achieve the purpose of treating both symptoms and root causes, and reduce the The frequency and dosage of medication have solved the problem of excessive drug residues. The preparation method of the composition for treating livestock and poultry diarrhea provided by the invention is simple in process and easy to realize, and the ingredients in the prepared preparation are evenly distributed, easy to use, and has good therapeutic effect.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a composition for treating livestock and poultry diarrhea and a preparation method thereof. Background technique [0002] At present, the drugs used to treat livestock and poultry diarrhea include norfloxacin lactate and acemequine. Norfloxacin Lactate belongs to the quinolone class of antibiotics. By acting on the bacterial DNA gyrase (gyrase A) subunit, it inhibits bacterial DNA replication and transcription to produce a bactericidal effect. It has a strong bactericidal effect on Gram-negative bacteria such as Pseudomonas aeruginosa, Escherichia coli, Salmonella, Pasteurella, Klebsiella pneumoniae, Aeromonas hydrophilic, etc., and also has a certain effect on mycoplasma. Intramuscular injection of norfloxacin lactate is absorbed rapidly, and the peak plasma concentration is reached within 1 to 2 hours. [0003] Methaquine belongs to antibacterial drug, and achieves antibac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/505A61K31/498A61K9/08A61P31/04A61P1/12A61P1/06A61K31/496A61K31/46
Inventor 王斌李旭廷李金良
Owner SICHUAN ANIMAL SCI ACAD
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