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Application of non-sulfated polysaccharide to preparation of guided bone regeneration drug

A sulfated polysaccharide, bone regeneration technology, applied in the directions of drug combination, bone diseases, pharmaceutical formulations, etc., can solve the problems of unstable sulfate group substitution site, unstable sulfate group content, unstable physiological activity, etc., and achieves a simple structure. , The effect of strong active function and stable structure

Inactive Publication Date: 2015-07-29
DALIAN POLYTECHNIC UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the application of polysaccharides with sulfate functional groups has some defects, such as the unstable content of sulfate groups and unstable substitution sites of sulfate groups. During the extraction and preparation, the products of each batch will change, and some reports even found that Occasionally, heparin not only does not activate but inhibits the activity of BMP-2, so its physiological activity is very unstable, resulting in occasional osteogenic activity of its products, which is not conducive to practical application

Method used

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  • Application of non-sulfated polysaccharide to preparation of guided bone regeneration drug
  • Application of non-sulfated polysaccharide to preparation of guided bone regeneration drug
  • Application of non-sulfated polysaccharide to preparation of guided bone regeneration drug

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Embodiment Construction

[0029] The invention discloses a non-sulfated polysaccharide capable of synergizing with BMP-2 to induce osteogenesis and regeneration, and is used for preparing medicines for inducing osteogenesis and regeneration. This polysaccharide structure has the following characteristics:

[0030] 1. It is mainly composed of mannose, and also contains a small amount of N-acetylglucosamine

[0031] 2. The main monosaccharide linkage types include 1-D-Manp, 1,6-D-Manp, 1,4-D-Manp and 1,3-D-Manp

[0032] 3. The polysaccharide does not contain sulfate groups and has the activity of synergizing with BMP-2 to induce osteogenesis and regeneration.

[0033] 4. The molecular weight of this polysaccharide is lower than 10kDa

[0034] 5. Its molecular structure is as follows:

[0035]

[0036] The shorthand is as follows:

[0037]

[0038] Preparation method: the polysaccharide of the present invention can be prepared by chemical synthesis or can be prepared from natural organisms, for ...

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Abstract

The invention discloses application of non-sulfated polysaccharide to preparation of a guided bone regeneration drug. According to the invention, polysaccharide is used for preparing the guided bone regeneration drug, cooperates with BMP-2 to promote regeneration of bone cells, and has the advantages of high activity and stability. The molecular weight of polysaccharide is smaller, and absorption and metabolism of an organism are facilitated due to no antigenicity; in addition, polysaccharide does not contain sulfate groups and is simple in structure, so that the drug activity is stable. Polysaccharide is found in the corpora lutea of sea urchins initially, so that risks, such as the risk of transmitting mammal viruses by heparin extracted from pigs and cattle, that viruses contained in a mammal preparation infect human bodies are avoided through the application of polysaccharide. Polysaccharide is stable in structure and high in active function, and side effects caused by application of heparin drugs are avoided. Polysaccharide can substitute for heparin in the application to the preparation of drugs for organ transplantation, bone injuries, osteoporosis and the like.

Description

technical field [0001] The invention relates to the pharmaceutical application of a polysaccharide, more specifically, to the application of preparing bone regeneration inducing drugs. Background technique [0002] With the rapid development of modern industry and transportation, bone defects caused by various traumas are increasing day by day. In addition, the treatment of diseases such as bone tumors, infections and deformities also requires bone grafting or bone substitute treatment. At present, autologous bone transplantation is still the most commonly used clinical method, but the limited availability of donors and related complications in the donor area limit its application and increase the suffering of patients. Allogeneic bone has great antigenicity, especially when a large bone defect requires more bone repair, bone graft failure is often caused by severe immune rejection, and the source of allogeneic bone is limited, there are still potential disease transmission ...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P19/10A61P19/08A61P19/00A61P37/06
Inventor 杨静峰高荣春衣萌张婷婷李月惠赵君朱蓓薇潘锦锋王南鹰
Owner DALIAN POLYTECHNIC UNIVERSITY
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