17 results about "Sulphated polysaccharides" patented technology

The present application relates to the field of biological medicine, and discloses a method for repairing female reproductive tract based on marine active substances, comprising the following steps: S1, providing a composition containing marine active substances, wherein the marine active substances comprise sea cucumber saponins, oyster polypeptides and brown alga polysaccharides; S2, formulating the composition into a topical gel preparation; S3, applying the topical gel preparation to the female reproductive tract through vaginal or intrauterine administration to perform endometrial regeneration, scar reduction or inflammation microenvironment improvement, wherein the sea cucumber saponins are derived from Holothuria scabra; the oyster polypeptides are derived from Crassostrea gigas; and the brown alga polysaccharides are derived from Sargassum thunbergii and are sulfated polysaccharides. By combining sea cucumber saponins, oyster polypeptides and brown alga polysaccharides in a specific ratio (0.5-1.2%, 1-2.5%, 2-4%), the repairing effect of the female reproductive tract is significantly improved, which is superior to single-component gel or existing hyaluronic acid gel.

This invention provides a method for preparing sulfated polysaccharides suitable for the production of microcapsules. [Solution] The present invention relates to a method for preparing sulfated polysaccharides. A mixture comprising at least one polysaccharide and at least one polar aprotic solvent is prepared in this method. At least one sulfating agent, at least one acetylating agent, and at least one peroxydisulfate are added to the mixture, and the mixture is then subjected to a temperature treatment so that at least one polysaccharide is converted to at least one sulfated acetate polysaccharide. At least one sulfated acetate polysaccharide is separated from the mixture and converted to a sulfated polysaccharide. The present invention further relates to sulfated polysaccharides that can be prepared using the method according to the present invention. The present invention further relates to microcapsules and methods for producing microcapsules.

The invention belongs to the technical field of marine polysaccharides, and relates to an anti-hypoxia urechis unicinctus body cavity fluid sulfated polysaccharide as well as a preparation method and application thereof. The weight-average molecular weight of the polysaccharide is 1000-50000 Da, the mass fraction of sulfate radicals is 10.0%-30.0%, and monosaccharide is prepared from galactose, ribose, fucose, glucosamine, mannose and glucose. The preparation method comprises the following steps: inducing controlled degradation of a main chain through high-temperature hot water extraction, carrying out proteolysis deproteinization, carrying out graded ethanol precipitation interception and carrying out anion exchange chromatography purification. The polysaccharide shows a remarkable protective effect in a nerve cell hypoxia simulation model, has excellent free radical scavenging activity, and can be used for preparing medicines, antioxidants, functional foods and the like for preventing or treating hypoxia-related diseases.

The present invention relates to a biomaterial comprising at least one elastomer matrix and a polysaccharide, and to its use in the reinforcement, reconstruction and / or filling of tissues, preferably in the reinforcement, reconstruction and / or filling of soft and / or epithelial tissue defects, preferably in the repair of skin and / or mucosa.

The invention is directed to a stable composition wash composition. The wash composition comprises a mixture of naturally derived and biodegradable sulfated polysaccharides. The wash composition has a viscosity of 40,000 cps or less, and surprisingly, is free of syneresis, discoloration and malodor, even after being stored at elevated temperatures.

The invention discloses a maltodextrin-included emulsified feed microcapsule and a preparation method thereof, and belongs to the technical field of pig feed. The emulsified feed microcapsule comprises a microcapsule wall material and a core material, and the core material comprises the following raw materials in parts by mass: 12-18 parts of bean pulp with skin, 35-50 parts of corn, 7-13 parts of broken rice, 1-5 parts of protein powder, 4-9 parts of corn bran, 3-6 parts of highland barley powder, 0.1-0.8 part of a compound enzyme preparation, 0.5-1.2 parts of a compound strain liquid, 2-4 parts of vegetable oil, 0.1-0.6 part of an emulsifier, 0.5-1.5 parts of amino acid and 0.2-0.8 part of sulfated polysaccharide; the microcapsule wall material is prepared from the following raw materials in parts by mass: 30 to 50 parts of maltodextrin, 8 to 12 parts of sodium caseinate and 0.5 to 2 parts of pectin-anthocyanin graft. The prepared emulsified feed microcapsule is high in embedding rate, can be quickly dissolved in water, and can reduce the diarrhea rate of piglets.

A sprayable formulation (2) for use in reducing or preventing viral infections and / or allergic reactions is disclosed, wherein the formulation comprises a barrier-forming material for forming a physical barrier with a mucosal membrane or ocular barrier against infection by and / or transmission of viruses and / or allergens, wherein the barrier-forming material comprises a naturally non-sulphated polysaccharide or derivative thereof, and the formulation does not comprise any additional materials which exhibit antiviral or antiallergy activity. Also disclosed is a formulation which does not comprise carrageenan, and a formulation wherein the barrier-forming material substantially consists of a naturally non-sulphated polysaccharide or derivative thereof. A spray device comprising the formulation is also disclosed.

The invention discloses a method for isolating sulfated polysaccharides from Gracilaria tenuistipitata. The method includes collection of sample, sample processing, extraction of sulphated polysaccharides, characterization using spectroscopic techniques and estimation of total carbohydrate and sulphate content to confirm structural and functional properties to yield high-purity sulphated polysaccharides with preserved bioactivity.

This application discloses a complex polysaccharide, its preparation method, and its applications. It discloses both a novel use of sulfated kudzu polysaccharide as a raw material for preparing drugs with anticoagulant effects and a complex polysaccharide comprising sulfated polysaccharide and polysaccharide fragments; wherein the sulfated polysaccharide includes sulfated kudzu polysaccharide and / or sulfated Bletilla striata polysaccharide; and the polysaccharide fragments include glycosaminoglycan fragments. This application modifies the structure of natural polysaccharides to improve their structural properties, preparing and screening complex polysaccharides with anticoagulant activity. The components in the complex polysaccharide work synergistically, significantly enhancing the anticoagulant effect and broadening the application fields of polysaccharides, primarily for the development of anticoagulant drugs and anticoagulant medical devices.

The present invention relates to an aqueous cosmetic composition containing a sulfated polysaccharide derived from Aphanothece sacrum, a colouring pigment or a pearlescent pigment, and an aqueous medium, wherein a content of sulfated polysaccharide derived from Aphanothece sacrum in the aqueous cosmetic composition is 0.03% by mass or more, and the colouring pigment or the pearlescent pigment is not subjected to a hydrophilization treatment on its surface; and a cosmetic product containing the aqueous cosmetic composition.

The present invention relates to an aqueous cosmetic composition containing: a sulfated polysaccharide derived from Aphanothece sacrum; a colored pigment or pearl pigment; and an aqueous medium. This aqueous cosmetic composition contains at least 0.03 mass% of sulfated polysaccharide derived from Aphanothece sacrum. The surface of the colored pigment or pearl pigment has not been hydrophilized. The present invention also relates to a cosmetic containing the aqueous cosmetic composition.

The invention relates to iterative application of compliance development and product upgrading of weight-losing and fat-reducing special medical series food, and belongs to the technical field of special medical purpose formula food (FSMP). According to the series of food, marine active substances (deep sea brown algae sulfated polysaccharide and chitin) and medicinal and edible components (nuciferine and hawthorn flavone) are taken as cores, the bioavailability is improved through a nano-carrier technology and a microcapsule embedding process, and the food conforms to the GB 29922-2013 special medical food standard. The product comprises a total nutrient base material (20-25% of protein and 15-20% of dietary fiber), functional components (8-10% of a marine active extract and 5-8% of a traditional Chinese medicine extract) and a metabolism regulator (3-5% of conjugated linoleic acid). Clinical tests show that after an obese patient takes 400 kcal of the replacement meal every day, the average weight is reduced by 9.5 kg (4.2 kg in a control group) after 12 weeks, and the body fat rate is reduced by 14.7%. The product supports strip iteration (such as powder, tablets and liquid diet) through modular formula design, and fills the market blank of weight-losing and fat-reducing special medical food.

This invention discloses a sustained-release sulfated polysaccharide-based bioblended membrane, its preparation method, and its applications, belonging to the fields of biomedical materials and cosmetics technology. Addressing existing sulfated polysaccharide-protein blend systems, this invention utilizes silk peptides of specific molecular weights as bidirectional interfacial bridges, combined with a sulfated polysaccharide film-forming matrix, hydrolyzed eggshell membrane proteins, and moisturizing and plasticizing components to construct a quaternary synergistic system. This achieves stable and controllable construction of protein self-assembled topological phase-separated microdomains. These continuous network-like topological phase-separated microdomains can form an interpenetrating reinforced network and a molecularly compatible soft interface with the polysaccharide matrix, inhibiting harmful phase separation while comprehensively improving the membrane's mechanical properties, sustained-release controllability, bioactivity, and batch stability. All components are naturally biodegradable and free of chemical cross-linking, making it suitable for applications such as medical dressings and functional skincare patches.

The invention presents an environmentally friendly method for producing silver nanopartic1es (AgNP) using sulfated polysaccharides from G. tenuistipitata. This green synthesis approach eliminates the need for harmful chemicals, making it suitable for a wide range of industrial, biomedical, and environmental uses. The resulting AgNPs are stable, uniform in size, and show significant bioactivity. Advanced characterization techniques, such as UV-Vis spectroscopy, FT-IR, FE-SEM, EDX, and XRD, confirm the nanopartic1es' high stability and bioactivity, highlighting their potential for various applications without relying on hazardous substances.

The present invention provides low molecular weight persulfated polysaccharides having anti-heparanase activity, prepared from marine natural exopolysaccharides secreted by mesophilic marine bacteria from deep-sea hydrothermal environments, and relates to the use of these low molecular weight persulfated polysaccharides for the prevention or treatment of mucopolysaccharidosis, particularly mucopolysaccharidosis type III (San Filippo syndrome). [Solution] The inventors have shown that low molecular weight persulfated polysaccharides obtained from marine natural exopolysaccharides (EPS) secreted by strain GY785 (Alteromonas infernus species of the genus Alteromonas) or from strain HE800 (Vibrio diabolicus species of the genus Vibrio) exhibit anti-heparanase (HPSE) activity.

Provided is a hair improver that can impart remarkably satisfactory hair moisture content, combability, and hair luster even with the use of an extremely small amount. This hair improver is characterized by containing a sulfated polysaccharide salt having a sulfate group at the 6-position of at least one sugar unit structure and salted with a monovalent cation. This sulfated polysaccharide may have, for example, any one of the following structural formulae:

[Problem] To provide a novel composition having gut microbiota regulating effect. [Solution] A composition for regulating gut microbiota, the composition being characterized by containing a sulfated polysaccharide that induces gut bacteria interactions in a host and alters the profile of the microbiota so that bacteria contributing to improving the host's health proliferate and pathogens are suppressed. The sulfated polysaccharide is preferably rhamnan sulfate. It is also preferable that the gut microbiota regulation (1) augments at least one selected from the group consisting of Prevotellaceae UCG-001, the Clostridia vadinBB60 group, and Mucispirillum schaedleri and (2) decreases at least one selected from the group consisting of the Rikenellaceae RC9 gut group, ASF356, and Staphylococcus.