Apparatus and methods for lateral flow ion mobility spectrometry

A kind of equipment and ion technology, applied in the field of equipment and methods for cross-flow ion mobility spectrometry analysis, can solve the problems of limited mobility resolution, low efficiency, limited accuracy of mobility measurement, etc.

Active Publication Date: 2017-06-09
BRUKER SCI LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Some of the other disadvantages of the above-mentioned prior art devices limit their mobility resolution and limit the sensitivity of instruments employing these devices (i.e., many target ions are lost due to the low efficiency of the mobility device) as well as the accuracy of mobility measurements. limit

Method used

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  • Apparatus and methods for lateral flow ion mobility spectrometry
  • Apparatus and methods for lateral flow ion mobility spectrometry
  • Apparatus and methods for lateral flow ion mobility spectrometry

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Embodiment Construction

[0081] As required, detailed exemplary embodiments of the present invention are disclosed herein. However, techniques, systems and operating structures in accordance with the present invention can be implemented in a variety of sizes, shapes, forms and modes, some of which are quite different from the disclosed embodiments. Therefore, the specific structural and functional details disclosed herein are representative only and, in this regard, are considered the best embodiment for disclosure purposes and provide the basis for the claims defining the scope of the invention.

[0082] The following text provides a detailed description of the preferred embodiment of the invention as well as some alternative embodiments of the invention. As noted above, the present invention generally relates to the analysis of mobility and mass spectrometry of chemical samples, and more particularly to mobility spectrometry combined with mass spectrometry. In particular, a system and method for ta...

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Abstract

A horizontal ion migration spectrum, including two parallel panels, defined a container between the two parallel plates.Analyst ions passed through the container along the entrance to the outlet.RF constraints guide ions along the axis.Establish an analysis airflow that is orthodox with the axis.The DC electrostatic analysis field is opposite to the direction of the analysis of the airflow, so that the "tension" of the analysis of the ion of the selected migration rate can be balanced by the electrostatic analysis field on the ion.Therefore, the selected pyramids can reach the exit of the analyzer of the horizontal migration analyzer along the stable path.However, the force on the ionic ion that works in non -selected migration is unbalanced, and these ions will be deviated and lost.

Description

[0001] Cross References to Related Applications [0002] Applicants hereby claim priority to US Patent Application No. 13 / 688,594, filed November 29, 2012, the disclosure of which is incorporated herein by reference. Background technique [0003] The present invention relates to methods for analyzing samples by ion mobility and by a combination of ion mobility and mass spectrometry. The devices and methods for sample processing and analysis described herein advance the state of the art involving mass spectrometry and ion mobility spectrometry, important tools in the analysis of a wide range of compounds. Specifically, ion mobility spectrometry can be used to determine the cross-section of an analyte ion, while mass spectrometry can be used to determine its molecular mass (more precisely, the ratio of molecular mass to charge, hereinafter referred to as mass). The analysis of a sample by ion mobility spectrometry and mass spectrometry involves three major steps—the formation o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/62
CPCG01N27/622H01J49/004H01J49/36
Inventor 梅尔文·安德鲁·帕克
Owner BRUKER SCI LLC
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