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Quality detection method of ephedra sinica-aconitum napellus-liquorice medicine

A quality inspection method, the technology of Mafugan, applied in the field of pharmaceuticals, can solve the problems that there is no quality inspection method for Mafugan, and the product quality cannot be effectively guaranteed.

Active Publication Date: 2015-08-19
SHANDONG TIANSHUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The Mafugan medicine described in the present invention has no method for detecting the quality of the Mafugan medicine in the prior art, and cannot effectively guarantee the product quality in production and use. Therefore, in order to ensure the quality of the Mafugan medicine and the clinical medication effect, a method is provided. It is very important to set simple and reliable quality standards

Method used

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  • Quality detection method of ephedra sinica-aconitum napellus-liquorice medicine
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  • Quality detection method of ephedra sinica-aconitum napellus-liquorice medicine

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Effect test

Embodiment 1

[0253] Embodiment 1: Mafugan granules are measured by the quality standard detection method of the present invention

[0254] 1) Preparation of granules:

[0255] Take 6 kg of aconite, 2 kg of ephedra, and 2 kg of licorice, add water to decoct twice, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second time, decoct for 1 hour, combine the two decoctions, Filter, concentrate to a thick paste, dry under reduced pressure below 80°C, pulverize, mix with appropriate amount of dextrin, make granules, dry, and granulate to obtain the granules of Mafugan drug.

[0256] 2) Inspection

[0257] Get the sample, check according to the quality standard detection method of the present invention, the results are shown in Table 40, the results show that the method of the present invention can effectively control the quality of Mafugan granules:

[0258] Table 40 Test results

[0259]

Embodiment 2

[0260] Embodiment 2: the granules, capsules, tablets, oral liquids and pills of Mafugan are measured by the quality standard detection method of the present invention

[0261] 1) Preparation of samples:

[0262] Granules, capsules, tablets, oral liquids, and pills of Mafugan are prepared according to different prescription ratios, extraction methods, and operating processes.

[0263] 2) Inspection

[0264] Get sample, check according to the quality standard detection method of the present invention, the result all meets the quality standard detection method requirement of the present invention, shows that the method of the present invention can effectively control Mafugan granule, capsule, tablet, oral The quality of liquids and pills.

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Abstract

The invention provides a quality detection method of ephedra sinica-aconitum napellus-liquorice medicine, which comprises the steps of adopting a thin layer chromatography method to identity ephedra sinica and liquorice; adopting a high performance liquid chromatography method to identity aconitum napellus and controlling diester alkaloid content: performing program gradient eluting on a moving phase according to time, and determining by adopting a reference substance mixing method; adopting the high performance liquid chromatography method, and polar ether-connected phenyl bonded silica gel is used as a filler for a chromatographic column; adopting the high performance liquid chromatography method to determine the contents of ephedra sinica and liquorice. The detection method can effectively ensure the quality of the medicine in a production and use process, so the therapeutic effect of the medicine is ensured.

Description

technical field [0001] The invention relates to a method for detecting the quality of Mafugan medicine, which belongs to the technical field of medicines. technical background [0002] Mafugan medicine is a medicine for treating cough after a cold and cough variant asthma. It is made of 6-18 parts of aconite, 1-9 parts of ephedra, and 1-9 parts of licorice (abbreviated as "Mafugan medicine"). It has a good curative effect on various symptoms of post-cold cough and cough variant asthma. [0003] The drug prescription of Mafugan described in the present invention is a proven prescription of traditional Chinese medicine clinical application for many years. The existing clinical application results show that this product has definite curative effect on post-cold cough and cough variant asthma, good long-term effect, and no adverse reactions. To a certain extent, it makes up for the shortcomings of chemical drugs that only control symptoms and have poor long-term effects. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/90
Inventor 刘金磊石红艳李诗标赵颖张为胜
Owner SHANDONG TIANSHUN PHARMA
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