Optimization method and system for adaptive radiation therapy

Abstract

The present invention provides an optimization method and system for adaptive radiation therapy. The method includes: determining the initial anatomical structure of the patient, and determining an initial scheme suitable for initial irradiation based on the initial anatomical structure, and performing a radiotherapy according to the initial anatomical structure. The fluence map is optimized to obtain the distribution of the fluence map; before each fractional irradiation, the current anatomical structure of the patient is determined, and the fluence map is optimized according to the current anatomical structure to obtain the fluence map distribution of the current fractional irradiation; Register the fluence map distribution of the current fractional irradiation with the fluence map distribution of the reference irradiation to obtain the deformation matrix, and the reference irradiation is any irradiation before the current fractional irradiation; Correction is performed to obtain the subfield shape of the current fractional irradiation, and the subfield weight optimization algorithm is used to determine the subfield weight of the current fractional irradiation. The invention can more accurately and quickly determine the shape of subfields in fractionated radiation therapy schemes.

Description

technical field [0001] The present invention mainly relates to an optimization technology for adaptive radiation therapy, and in particular to an optimization method and system for adaptive radiation therapy based on fluence map changes. Background technique [0002] In the prior art, there are mainly two-step method and direct sub-field optimization method for the optimization method of radiotherapy plan, wherein, the two-step method includes two parts of fluence map optimization and field segmentation. Generally speaking, the optimization results obtained by the fluence map optimization in the two-step method are better than or equal to the optimization results obtained by the direct subfield optimization method. However, for the two-step method, the result of fluence map optimization needs to go through the step of field segmentation to obtain the final leaf sequence of the multi-leaf collimator. However, in the field segmentation step, it is an NP-hard problem to divide...

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Problems solved by technology

[0008] However, since the relationship between the subfield shape and the patient's internal anatomical structure is very complex and not a simple linear relationship, the current method of correcting the subfield shape of the initial scheme according to the deformation matrix of the anatomical structure cannot accurately obtain the current subfield shape. The subfield shape of the radiotherapy plan

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