Application of amydrium sinense extract in preparing myocardial anti-ischemia and anti-anoxia product

An anti-myocardial ischemia, Lei Gonglian technology, applied in application, food preparation, cardiovascular system diseases, etc., to achieve stable performance, significant effects, and easy access to raw materials.

Active Publication Date: 2015-09-09
贵州中医药大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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  • Application of amydrium sinense extract in preparing myocardial anti-ischemia and anti-anoxia product
  • Application of amydrium sinense extract in preparing myocardial anti-ischemia and anti-anoxia product
  • Application of amydrium sinense extract in preparing myocardial anti-ischemia and anti-anoxia product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1: Preparation of Lei Gonglian Extract

[0050] Soak Lei Gonglian medicinal material in 95%, 75%, and 50% ethanol respectively for 4 times, each time for 15 hours, until the color becomes lighter, combine the soaking liquid, recover the ethanol, and obtain the ethanol extract; place the ethanol extract at 70°C Volatilize in a water bath until there is no alcohol smell, first extract 4 times with 1.5 times the volume of petroleum ether, discard the petroleum ether extract and aqueous solution, then extract 4 times with 1.5 times the volume of ethyl acetate, discard the ethyl acetate extract and aqueous solution Finally, extract 5 times with 2 times the volume of n-butanol, take the n-butanol extract and recover it under reduced pressure until it has no alcohol smell, and obtain the n-butanol extract, dissolve it in water, put it on a macroporous resin column, and wash it with distilled water first. After the eluate is colorless, use 12 times column volume of 5...

Embodiment 2

[0051] Embodiment 2: the preparation of Lei Gonglian extract

[0052] Soak Lei Gonglian medicinal material in 95%, 75%, and 50% ethanol respectively for 3 times, each time for 24 hours, until the color becomes lighter, combine the soaking liquid, recover the ethanol, and obtain the ethanol extract; place the ethanol extract at 70°C Volatilize in a water bath until there is no alcohol smell, first extract 5 times with 0.5 times the volume of petroleum ether, discard the petroleum ether extract and aqueous solution, then extract 3 times with 2 times the volume of ethyl acetate, discard the ethyl acetate extract and aqueous solution Finally, extract 6 times with 0.5 times the volume of n-butanol, take the n-butanol extract and recover it under reduced pressure until it has no alcohol smell, and obtain the n-butanol extract. After dissolving in water, put it on a macroporous resin column and wash it with distilled water first. After the eluate is colorless, elute with 8 times colu...

Embodiment 3

[0053] Embodiment 3: the preparation of Lei Gonglian extract

[0054] Soak Lei Gonglian medicinal material in 95%, 75%, and 50% ethanol respectively for 5 times, each time for 6 hours, until the color becomes lighter, combine the soaking liquid, recover the ethanol, and obtain the ethanol extract; place the ethanol extract at 70°C Volatilize in a water bath until there is no alcohol smell, first extract 3 times with 2 times the volume of petroleum ether, then extract 5 times with 0.5 times the volume of ethyl acetate, and finally extract 3 times with 3 times the volume of n-butanol, take n-butanol The extract is recovered under reduced pressure until it has no alcohol smell, and the n-butanol extract is obtained. After dissolving in water, put it on a macroporous resin column, wash it with distilled water first, and then use 50% of 15 times the column volume to wash it until the eluate is colorless. Ethanol is eluted at a rate of 2 times the column volume / h, the ethanol eluate...

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Abstract

The invention discloses an application of an amydrium sinense extract in preparing a myocardial anti-ischemia and anti-anoxia product. The activity of the amydrium sinense extract is deeply researched; by testing influence on ISO (Isoprenaline Hydrochloride Injection) mouse myocardial acute ischemia electrocardiogram T-wave, influence on mouse normal pressure anoxia resistance, influence on ISO mouse myocardial acute ischemia normal pressure anoxia resistance and influence on beheaded mouse ischemia anoxia breathing time, the amydrium sinense extract can effectively inhibit the lifting of myocardium ST-T, improve normal mouse normal pressure anoxia resistance, improve ISO mouse acute myocardial ischemia normal pressure anoxia resistance, and prolong beheaded mouse ischemia anoxia breathing time, and the amydrium sinense extract is indicated to have an remarkable effect on resisting myocardial ischemia and anoxia. Therefore, the amydrium sinense extract is obvious in activity, stable in performance, safe and reliable, and can be used for preparing the myocardial anti-ischemia and anti-anoxia product. Besides, materials of the amydrium sinense extract are easy to get, an extraction process is simple, and industrial production is easy.

Description

technical field [0001] The invention relates to the application of Lei Gonglian extract in the preparation of anti-myocardial ischemia and hypoxia products, and belongs to the technical field of application of active ingredients of medicinal materials. Background technique [0002] Myocardial ischemic disease is a focus of cardiovascular diseases, and myocardial ischemia and hypoxia are also the common pathological basis of myocardial infarction and ischemic heart disease. Insufficient myocardial blood supply and oxygen supply lead to myocardial metabolic disorder, insufficient energy supply, decreased myocardial contractile function, and reduced blood output, which in turn affects the function of the entire body and even causes myocardial cell death. Therefore, clinical research and experimental research on cardiovascular diseases, especially myocardial ischemia and hypoxia, have generally received attention. [0003] Myocardial ischemia and hypoxia belong to the category ...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61P9/10A61P9/00A23L1/30
Inventor 吴红梅王祥培李欣灿王远敏钱海兵
Owner 贵州中医药大学
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