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Haemodiafiltration method

A technology of hemodialysis and hemofilter, which is applied in the direction of dialysis system, blood circulation treatment, drug equipment, etc., can solve the problem of unavailability

Active Publication Date: 2015-09-09
FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While it would be expected that after removal of soluble toxin from the blood, an equilibrium between free toxin and protein-bound toxin would be re-established, and if the dialysis time was long enough, a substantial portion of the toxin could be removed, this time in Not available during hemodialysis treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] The effect of high-frequency electromagnetic fields on the protein-binding moieties of uremic toxins was examined in a series of in vitro experiments.

[0065] A dialysis module is provided for this purpose, where conventional blood filtration capillaries are considered as circuits using silicone into the syringe receiving neck. In the presence of the uremic toxins phenylacetic acid, p-hydroxyhippuric acid and indoxyl sulfate, aqueous albumin solutions were introduced into the corresponding modules. The solution was filtered with a dialysis module for 10 minutes using a syringe pump. Subsequently, a high-frequency electromagnetic field is induced in the solution by using a high-frequency electrode (HF electrode). The electromagnetic field was increased from 1 MHz to 20 MHz in steps of 1 MHz during a period of 10 minutes by means of a high-frequency voltage source. The concentrations of the uremic toxins phenylacetic acid, p-hydroxyhippuric acid and indoxyl sulfate pre...

Embodiment 2

[0068] Inspection of HF field effects in the frequency range 1 to 170MHz.

[0069] An aqueous solution of bovine serum albumin (BSA, 60 mg / ml) was introduced into the dialysis module of Example 1 in the presence of the uremic toxin phenylacetic acid (1 mmol / l in 0.9% NaCl solution). The HF field was varied in sub-bands of 10 MHz within the frequency range 1-170 MHz and compared to a control experiment without HF field.

[0070] Quantitative determination of phenylacetic acid was performed using HPLC.

[0071] exist Figure 4 Collect the results of the experiments. Under the influence of the HF field, the separation rate for phenylacetic acid can be increased by at least 45.3%. In the sub-band from 110 to 120 MHz, the effect is particularly pronounced at 54.6%.

Embodiment 3

[0073] This example continues from the examination according to Example 2, which shows that the influence is particularly pronounced in the sub-band from 110 to 120 MHz.

[0074] In a further examination according to Example 3, the frequency range of approximately 110 to 115 MHz could in particular be identified as an effective frequency range for the release of protein-bound uremic toxins. Figure 5 The respective effects on the corresponding release and subsequent separation of phenylacetic acid are shown.

[0075] According to the current state, the frequency ranges schematically named in Table 1 are suitable for the isolation of protein-bound uremic toxins.

[0076] Table 1: Suitable frequencies in the HF field

[0077]

[0078] The corresponding frequency range is the range in which the maximum separation effect is determined. The increased separation was partially determined in the unnamed frequency range compared to the control; however, the increased separation wa...

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Abstract

The invention relates to a device for haemodiafiltration comprising an extracorporeal circulation (10) for receiving blood to be cleaned and comprising a haemodialyser and / or haemofilter (20) which is connected to the blood circulation (10), said blood circulation (10) having at least one respective supply line (12, 14) located upstream and downstream of the haemodialyser and / or haemofilter (20), for supplying a substitution fluid. The invention is characterised in that the device also comprises measuring devices for recording the transmembrane pressure and / or haematocrit (HKT) and / or blood density, the measuring devices being connected to a control unit (100) for controlling one or more of the transmembrane pressure, and / or haematocrit (HKT) and / or blood density and said control unit (100) being constructed in such a way that the control is carried out (13, 15) with the aid of at least one of the infusion speeds (Qspre, Qspost) of the substitution fluid. The invention is also characterised in that the blood to be cleaned is exposed to a high-frequency electromagnetic field and / or an electric DC field (70) before and / or during the contact with the dialyser.

Description

technical field [0001] The invention relates to a device for performing hemodiafiltration treatment under the influence of an alternating electromagnetic field and / or a direct electric field. Background technique [0002] The purpose of a healthy kidney is to remove the end products of metabolism (substances that must be removed in the urine) and toxins from the body (uremic toxins) by forming urine. The kidneys remove a broad spectrum of substances with different molecular weights. R. Vanholder et al. (R. Vanholder et al., Kidney International, No. 63 (2003) pp. 1934-1943) published a review of uremic toxins. Uremic toxins are classified into three classes according to their molecular weight. Toxins having a molecular weight of less than 500 Daltons form low molecular weight radicals. Intermediate sized molecules are in the middle range of molecular weight between 500D and 12000D. Medium-sized molecules include, for example, beta 2 - Microglobulin (11800D). A third ur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/16A61M1/36
CPCA61M1/3612A61M1/361A61M2205/054A61M1/3681A61M1/3434A61M2202/0445A61M1/16A61M2202/0498A61M2205/3344A61M2230/207A61M1/3609A61M1/3639A61M1/3403
Inventor U·泰斯古勒纳J·杨科夫斯基A·菲比格C·缪勒
Owner FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
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