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Application of minocycline in protection of retinal ganglion cells

A retinal ganglion, minocycline technology, applied in nervous system diseases, active ingredients of tetracycline, sensory diseases, etc., can solve the problem of lack of drugs for optic nerve damage, and achieve the effect of high application prospects

Inactive Publication Date: 2015-09-23
PEKING UNIV FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is still a lack of effective drugs for the treatment of optic nerve injury in clinical practice.

Method used

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  • Application of minocycline in protection of retinal ganglion cells
  • Application of minocycline in protection of retinal ganglion cells
  • Application of minocycline in protection of retinal ganglion cells

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Example 1. Research on protection of retinal ganglion cells by minocycline

[0030] 1. Clean-grade healthy male C57BL / 6J mice were raised in a barrier environment in the animal room of Peking University First Hospital. The mice were randomly divided into three groups: normal control group (8 rats), normal saline group (64 rats), and minocycline group (64 rats). This animal experiment was reviewed by the Ethics Committee of Peking University First Hospital.

[0031] 2. Optic nerve clamp injury and postoperative management

[0032] The mouse optic nerve clamp injury model is an ideal model for studying RGC neuroprotection. Since the blood supply in the eye is not interrupted, the optic nerve clamp has advantages over other models such as the optic nerve transection model (Templeton JP, Geisert EE. A practical approach to optic nerve crush in the mouse. Mol Vis2012;18:2147-2152. )

[0033] (1) The mice in the normal control group received no treatment.

[0034] (2) Ac...

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Abstract

The invention discloses an application of minocycline in protection of retinal ganglion cells. The invention discloses the application of minocycline in preparation of products for protecting the retinal ganglion cells. Minocycline is proved to play a nerve protection role to a certain extent by an autophagy and NF-kappa B regulating way at early stage after optic nerve injury, and have high application prospects in clinical treatment after optic nerve injury.

Description

technical field [0001] The invention relates to the application of minocycline in protecting retinal ganglion cells. Background technique [0002] The retina and optic nerve are part of the central nervous system. Damage to the central nervous system is irreversible, so optic nerve damage from various causes, such as trauma, inflammation, and high intraocular pressure, can lead to loss of retinal ganglion cells (RGCs), eventually leading to permanent vision loss or even blindness. At present, there is still a lack of effective drugs for the treatment of optic nerve injury. Minocycline (minocycline) is a semi-synthetic tetracycline that has been safely used in clinical treatment as a broad-spectrum antibiotic. Contents of the invention [0003] The purpose of the present invention is to provide an application of minocycline in protecting retinal ganglion cells. [0004] The invention provides the application of minocycline in preparing products for protecting retinal gan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/65A61P27/02A61P25/00
Inventor 杨柳焦晓玲彭媛
Owner PEKING UNIV FIRST HOSPITAL
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