A drug efficacy evaluation method and system based on molecular network

A molecular network and drug efficacy evaluation technology, applied in the field of network pharmacology, can solve the problem of not being able to quantitatively understand drug treatment effects in a systematic and overall manner.

Inactive Publication Date: 2019-02-01
INST OF BASIC RES & CLINICAL MEDICINE CHINA ACAD OF CHINESE MEDICAL SCI
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  • Abstract
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  • Application Information

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Problems solved by technology

This can only quantitatively reflect the effect of markers, and cannot systematically and quantitatively understand the therapeutic effect of drugs
However, there are no reports on the overall quantitative analysis of drug treatment effects in a web-based system

Method used

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  • A drug efficacy evaluation method and system based on molecular network
  • A drug efficacy evaluation method and system based on molecular network
  • A drug efficacy evaluation method and system based on molecular network

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 3

[0054] Embodiment 1 Three kinds of anti-rheumatic drugs and ligustrazine combination treatment effect evaluation of rheumatoid arthritis

[0055] 1 Introduction

[0056] Clinical trials have shown that the combination of some commonly used antirheumatic drugs and antithrombotic Ligustrazine is more effective in treating rheumatoid arthritis than when it is used alone. However, it is unclear which aspects are supplemented or synergized after the combination, how the treatment mechanism affects rheumatoid arthritis, and what are the side effects. Here, this method is used to systematically analyze and evaluate the efficacy of leflunomide, methotrexate, and triptolide in combination with ligustrazine, three commonly used antirheumatic drugs, in the treatment of rheumatoid arthritis.

[0057] 2 methods

[0058] 2.1 Large-scale high-throughput approach to obtain three anti-rheumatic drugs and ligustrazine-related genes or proteins

[0059] Three antirheumatic drugs, leflunomide,...

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Abstract

The invention relates to network pharmacology, and concretely discloses a medicine effect evaluating method based on a molecular network and a medicine effect evaluating system. The method comprises the following steps that of: (1) obtaining data through various paths; (2) building a medicine effect molecular network and a disease molecular network; (3) mapping a corresponding medicine molecular network to the disease molecular network to generate a medicine treatment effect molecular network; (4) performing centrality analysis on the disease molecular network; and (5) quantificationally evaluating the influence degree of medicine on diseases and the influence degree of each treatment mechanism on the diseases by the center value distribution of molecules of the medicine treatment effect molecular network in the disease molecular network. The invention provides a good method for reasonable administration research, screening of new use of conventional medicine, combined new medicine development and the like.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a network pharmacology method for evaluating drug efficacy by applying biological information and computational biology technology. Background technique [0002] Pharmacodynamics, that is, pharmacodynamics, is the study of the effects and mechanisms of drugs on the body, including therapeutic effects and adverse reactions such as side effects. The emerging network pharmacology is researched from the perspective of systems biology, especially from the perspective of biological networks. The current research method is to construct a one-element network (interaction network between molecules in the body related to drugs) or a two-element network (drug and The interaction network between molecules in the body and between molecules in the body), and then network analysis and biological annotation, in-depth understanding of the role of substances on the body and the mechanism of action. [000...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/15
Inventor 陈杲何小鹃吕诚姜淼牛旭艳何冰梁超刘彪郭保生刘进党蕾李德芳张戈吕爱平
Owner INST OF BASIC RES & CLINICAL MEDICINE CHINA ACAD OF CHINESE MEDICAL SCI
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