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External application patch containing enalapril and application thereof

A technology of enalapril and patch, applied in the direction of active ingredients of heterocyclic compounds, tablet delivery, cardiovascular system diseases, etc., can solve problems such as unstable antihypertensive effect, poor oral absorption, slow onset of action, etc. Achieve the effect of avoiding the peak and valley phenomenon of blood drug concentration, easy to use and easy to accept

Inactive Publication Date: 2015-10-21
徐静 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to overcome the poor oral absorption, slow onset and unstable antihypertensive effect in the prior art when enalapril treats hypertension, and it cannot make the drug enter the human body at a constant rate for a long time. In order to provide a long-acting, skin-absorbed, fast-acting, balanced and stable antihypertensive effect, good patient compliance, easy to carry and use, an external patch containing enalapril medicine

Method used

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  • External application patch containing enalapril and application thereof
  • External application patch containing enalapril and application thereof
  • External application patch containing enalapril and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1: To prepare a matrix-type external patch containing enalapril:

[0036] Raw materials Composition ratio (g) Enalapril6.0 Pure water18.0 Waterborne acrylic pressure sensitive adhesive66.0

[0037] Prepare according to the following preparation process:

[0038] ① Dissolve enalapril in pure aqueous solution, add water-based acrylic pressure-sensitive adhesive and mix well. ②Apply the mixed glue to the backing material with an area of ​​20000cm 2 , Heat and dry, and then cover with a protective layer. ③ It is cut according to the required size and packaged to form a matrix transdermal patch containing the pharmaceutical composition.

Embodiment 2

[0039] Example 2: To prepare a matrix-type external patch containing enalapril:

[0040] Raw materials Composition ratio (g) Enalapril10.0 Pure water15.0 Waterborne acrylic pressure sensitive adhesive60.0

[0041] Prepare according to the following preparation process:

[0042] ① Dissolve enalapril in pure aqueous solution, add water-based acrylic pressure-sensitive adhesive and mix well. ②Apply the mixed glue to the backing material, area 4000cm 2 , Heat and dry, and then cover with a protective layer. ③ It is cut according to the required size and packaged to form a matrix transdermal patch containing the pharmaceutical composition.

Embodiment 3

[0043] Example 3: To prepare a matrix-type external patch containing enalapril:

[0044] Raw materials Composition ratio (g) Enalapril10.0 Glyceryl triacetate3.0 50% ethanol aqueous solution20.0 Waterborne acrylic pressure sensitive adhesive85.0

[0045] Prepare according to the following preparation process:

[0046] ① Dissolve enalapril and azone in 50% ethanol aqueous solution, add water-based acrylic pressure-sensitive adhesive and mix well. ②Apply the mixed glue to the backing material, area 5000cm 2 , Heat and dry, and then cover with a protective layer. ③ It is cut according to the required size and packaged to form a matrix transdermal patch containing the pharmaceutical composition.

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PUM

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Abstract

The invention relates to an external application patch containing enalapril and a preparation method thereof. Enalapril is used as the main medicine of the external application patch and used for treating high blood pressure. According to the external application patch containing the enalapril, medicine release is even through transdermal absorption, the action is moderate and durable, the external application patch directly acts on the skin and will not be absorbed through the gastrointestinal tract, the first pass effect of the liver is avoided, adverse effects are reduced, and the occurrence rate of the adverse effects is reduced. The compliance of a patient is good, and the external application patch is convenient to use and carry.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a pharmaceutical preparation for external use, in particular to an external preparation containing enalapril and its application. Background technique [0002] Enalapril is an angiotensin converting enzyme inhibitor (ACEI). After oral administration, it is hydrolyzed into enalaprilat in the body, which has a strong inhibitory effect on angiotensin-converting enzyme, reduces the content of angiotensin II, causes systemic vasodilation, and lowers blood pressure. It is used to treat hypertension. Long-lasting effect. This product lowers blood pressure while maintaining myocardial contractility without affecting cardiac output. In patients with congestive heart failure, it can reduce peripheral vascular resistance and pulmonary capillary wedge pressure, thereby reducing cardiac preload and afterload and improving cardiac function. This product can i...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/40A61P9/12
Inventor 徐静张艳红徐光昳
Owner 徐静
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