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Application of Nicardipine in preparation of lung cancer resistant product

A product, lung cancer technology, applied in the application field of Nicardipine in the preparation of anti-lung cancer products, can solve the problems of ineffective anti-tumor drugs, unknown side effects, and large genetic variation of individual tumors.

Active Publication Date: 2015-10-21
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, with the rapid development of tumor genomics and molecular pharmacology, the research and development of new anti-tumor drugs has achieved good results, but due to the large investment in new drug research and development, the bottlenecks such as long cycle cannot be overcome, and the genetic variation of individual tumors is large, etc. characteristics, leading to the ineffectiveness of many traditional antineoplastic drugs, expensive new drugs, and unknown side effects

Method used

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  • Application of Nicardipine in preparation of lung cancer resistant product
  • Application of Nicardipine in preparation of lung cancer resistant product
  • Application of Nicardipine in preparation of lung cancer resistant product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1. CELLTITER-GLO detects Nicardipine against non-small cell lung cancer

[0045] 1. Preparation of the well plate to be tested

[0046] 1. Cell plating

[0047] a) Prepare complete medium required for each cell

[0048] b) Before the experiment starts, confirm the name of the sieve cell, the culture medium, and the passage time, generation time and other information marked on the 100mm petri dish to ensure that the experiment is correct.

[0049] c) Refer to steps d) to i) for adherent cell operation, and steps j) to l) for suspension cell operation.

[0050] d) Use a vacuum pump to suck cell culture medium during aseptic operation.

[0051] e) Wash the cell surface with 2ml of sterile PBS solution, and then suck out the PBS waste liquid with a vacuum pump.

[0052] f) Gently add 1ml of 0.25% (w / v) Trypsin-0.038% (w / v) EDTA solution to the culture dish to digest the cells, mix gently for a few times, the solution covers the surface of the cells, observe the cell digestion un...

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Abstract

The invention discloses an application of Nicardipine in preparation of a lung cancer resistant product, and provides an application of the Nicardipine in preparation of a lung cancer curing product. An experiment of the application proves that relocation of an anti-tumor drug is carried out on the Nicardipine which is approved by the FDA and the CFDA, according to different cell lines (histopathological types) and mutation sites of a tumor, screening is carried out to screen out drugs showing indications which are not resistant to tumors, novel uses / a novel use of being resistant to small cell lung cancer and / or resistant to non-small cell lung cancer of the Nicardipine are / is found, and the novel uses / the novel use for the approved drug are / is achieved.

Description

Technical field [0001] The invention relates to the field of biotechnology, in particular to the application of Nicardipine in the preparation of anti-lung cancer products. Background technique [0002] Tumor is the most common and most serious disease threatening human health. The development of highly effective anti-tumor drugs is essential to prolong the life cycle of patients. In recent years, with the rapid development of tumor genomics and molecular pharmacology, the development of new anti-tumor drugs has achieved good results. However, due to the large investment in new drug development, the long cycle and other bottlenecks cannot be overcome, as well as the large genetic variation of individual tumors. Characteristics, leading to the ineffectiveness of many traditional anti-tumor drugs, new drugs are expensive, and side effects are unknown. [0003] Researchers such as Barabasi AL pointed out in a paper published in Nature Reviews Genetics in 2011 that molecular network a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61P35/00
Inventor 师咏勇宋智健
Owner SHANGHAI JIAO TONG UNIV
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