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Traditional Chinese medicine compound composition for treating piglet pullorum

A composition and technology of traditional Chinese medicine, applied in the field of compound Chinese medicine composition, can solve the problems of reduced therapeutic effect and low drug resistance

Active Publication Date: 2018-04-17
SHANGHAI VETERINARY RES INST CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, a low-toxic, high-efficiency, non-residual drug has been developed, but due to the problem of drug resistance caused by the long-term use of antibiotics and chemical drugs, the therapeutic effect of many drugs on E. coli diarrhea has been continuously reduced, and antibiotics and drug residues have been caused. Drugs with low drug resistance have become an urgent problem to be solved in the prevention and treatment of colibacillosis in piglets

Method used

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  • Traditional Chinese medicine compound composition for treating piglet pullorum
  • Traditional Chinese medicine compound composition for treating piglet pullorum
  • Traditional Chinese medicine compound composition for treating piglet pullorum

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1. Experiment on the treatment of diarrhea in mice

[0015] 1.1 Experimental animals and strains

[0016] 20±2g male Kunming mice were purchased from Shanghai Slack Experimental Animal Co., Ltd.; pathogenic porcine Escherichia coli were purchased from China National Institute of Pharmaceutical and Biological Products.

[0017] 1.2 Drug preparation

[0018] 50 grams of Coptis chinensis, 45 grams of Scutellaria baicalensis, 45 grams of Pulsatilla chinensis, 45 grams of Qinpi, 45 grams of dandelion, 45 grams of kudzu root, 40 grams of gallnut, 40 grams of Cortex Phellodendri, 40 grams of raw rhubarb, 30 grams of forsythia, 40 grams of honeysuckle, 40 grams of astragalus and Distilled water was mixed according to the weight ratio of 1:10, soaked for 30 minutes, decocted twice for 30 minutes each time, combined the filtrate, then filtered to remove impurities, and concentrated under reduced pressure to obtain Chinese medicine compound water containing crude drug 1g / mL for t...

Embodiment 2

[0034] 2. Treatment of piglet diarrhea test

[0035] 2.1 Test drugs

[0036] Chinese medicine compound decoction is the same as in Example 1. Bacterial classification is with embodiment 1.

[0037] 2.2 Test animals

[0038] Thirty 21-day-old Du and Sanyuan hybrid piglets.

[0039] 2.3 Experimental design

[0040] Thirty 21-day-old piglets were randomly divided into 3 groups, namely compound drug group, blank control group and model control group, with 10 piglets in each group. The compound drug group and the model control group were fed with 5mL Escherichia coli liquid (3×10 9 CFU / mL) for 3 consecutive days; the blank control group was fed with 5 mL of normal saline every day for 3 consecutive days. The compound medicine group was given compound decoction 10mL / 10Kg per head, twice a day, for 7 consecutive days; the blank control group and the model control group were given the same dose of normal saline. The piglets are raised at an ambient temperature of about 25°C, fr...

Embodiment 3

[0054] 3. Experiment on the treatment of pullorum in piglets

[0055] 3.1 Test drugs

[0056] Chinese medicine compound decoction is the same as in Example 1. Shigella pure powder, batch number 20140707, specification 100g / bag.

[0057] 3.2 Test animals

[0058] Select 100 weaned piglets suffering from pullorum in the pig herd.

[0059] 3.3 Experimental design

[0060] 100 sick weaned piglets were divided into two groups, 50 pigs in each group, and the compound Chinese medicine composition and dysentery pure powder were used respectively. The Chinese medicine compound composition solution was taken orally, twice a day for each head, 5ml each time; the dysentery pure powder was administered in drinking water, and 1 gram of medicine was added to every kilogram of water.

[0061] 3.4 Measuring indicators

[0062] The cure rate is the percentage of the number of cured heads to the number of treated heads. The number of cured cases refers to the disappearance or reduction of...

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Abstract

The invention discloses a Chinese medicine compound composition for treating piglet pullorum. The composition is prepared by mixing the following Chinese medicine raw materials with distilled water, soaking, decocting, filtering to remove impurities, combining filtrates, and concentrating under reduced pressure. The weight percentage of Chinese medicine raw materials is as follows: : Coptidis 5‑10%, Scutellaria baicalensis 5‑10%, Pulsatilla 5‑10%, Qinpi 6‑10%, Dandelion 5‑10%, Pueraria 5‑10%, Galla chinensis 4‑8%, Phellodendron 2‑8%, raw Rhubarb 2‑8%, Forsythia 2‑6%, Honeysuckle 2‑8%, Astragalus 2‑8%. The present invention is based on the cause of the onset of pullorum in piglets, aiming at the common Escherichia coli that causes piglets to infect the disease clinically, and treats it with medicinal prescriptions such as clearing away heat and dampness, clearing away heat and detoxifying, clearing away heat and cooling blood, etc.; Diarrhea and immune-enhancing effects have significant beneficial effects on the treatment of piglet pullorum.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine composition, in particular to a compound traditional Chinese medicine composition for treating pullorum of weaned piglets. Background technique [0002] In today's large-scale breeding production process, piglet diarrhea has become a common disease in animal epidemics, and its high incidence seriously hinders the healthy and sustainable development of the breeding industry. At present, yellow and white scours of piglets occur all over the world. In countries with more developed pig farming such as the United States, the incidence of yellow and white scours of piglets is about 20%, and the mortality rate is 15.5%. The incidence of yellow and white scours of Dutch piglets is 16.5%. Around 11.5% -4.2% mortality rate. Some data show that the incidence of colibacillosis in pig herds in my country has reached more than 60%, among which the incidence of pullorum in piglets is also nearly 90%, a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/756A61P1/12A61P31/04A61P37/04A61K35/64
Inventor 王米杨锐乐薛飞群张丽芳费陈忠王霄旸张可煜孟新宇郑文丽肖遂王春梅
Owner SHANGHAI VETERINARY RES INST CHINESE ACAD OF AGRI SCI
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