A bio-3D printing nozzle for high and low temperature combination
A 3D printing, high and low temperature technology, applied in coating devices, processing heating elements, additive processing, etc., can solve the problems of inability to accurately locate cells and biological materials, limited cell implantation technology, etc., to achieve simplified architecture, cost reduction effect
Active Publication Date: 2017-07-11
ZHEJIANG UNIV
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Problems solved by technology
[0003] Traditional tissue engineering research has been limited by cell implantation technology, that is, in the inherent technical link of tissue engineering, "implanting cells on the scaffold", it is impossible to accurately locate different types of cells and biomaterials to different spatial positions inside the scaffold.
In fact, with the advancement of tissue engineering research, research work has gradually extended to large soft tissues and internal organs, because these tissues and organs often contain a variety of cells and biological materials, and different cells or materials have specific spatial arrangements. , so the above technical limitations are more prominent
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[0027] Attached below Figure 1-8 And embodiment further illustrates the concrete structure of the present invention, working principle and working process content.
[0028] A biological 3D printing nozzle for high and low temperature combination has a heating and cooling device, which can realize precise control of various temperatures. The nozzle includes an outer shell 1, a heat conduction block 3, a heating rod 9, a cooling fin 4, a heat sink 10, and a fan 11 , the syringe 8, the upper baffle plate 2 of the heat conduction block, the lower baffle plate 5 of the heat conduction block, the screw cap 7 and the needle head 6; the heat conduction block 3 is installed in the outer casing 1, and the heating rod 9 is installed inside the heat conduction block 3; The cooling fin 4 is mounted on the outer surface of the heat conduction block 3; the heat sink 10 is mounted on the outer casing 1 and contacts the cooling fin 4; the fan 11 is mounted on the surface of the heat sink 10; ...
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The invention discloses a biological 3D printing nozzle with a combination of high and low temperature, which has a heating and cooling device and can realize precise control of various temperatures. cylinder, heat conduction block upper baffle, heat conduction block lower baffle, cap and needle. In the present invention, a heating rod and a syringe are installed in the heat conducting block, and the material in the syringe can be heated through the heating rod; at the same time, a cooling fin is attached to an outer surface of the heat conducting block, and the cooling fin is connected with the heat sink and the fan. The material in the barrel can be cooled. In this way, one nozzle can print materials at different temperatures, which simplifies the structure of the nozzle and reduces the cost.
Description
technical field [0001] The invention relates to a biological 3D printing nozzle for high and low temperature combination, which is used for printing cells and biological materials, and belongs to the field of tissue engineering technology and biological 3D printing. Background technique [0002] For the treatment of damaged large soft tissues and internal organs, human tissue and organ transplantation is an extremely effective treatment method. However, due to the shortage of organ donor sources, immune rejection and other problems, there are insurmountable difficulties in the practical application of organ transplantation. The proposal of tissue engineering has opened up a new way to solve the above problems. Tissue engineering is to attach living cells to biomaterial matrices or prepared scaffolds by a certain method to construct functional tissue substitutes. The constructed tissue substitutes are then cultured and implanted into the patient's body to replace the origin...
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IPC IPC(8): B29C64/209B29C64/295B29C64/20B33Y30/00
Inventor 张斌张刚姜鹏马吉恩杨华勇
Owner ZHEJIANG UNIV