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Network quality analysis method and apparatus

A mass analysis device and mass analysis technology, applied in the field of mass spectrometer and ion mass analysis, can solve the problems of obstructing the acquisition of ions, low duty cycle, lost ions, etc., and achieve the effect of improving the mass analysis duty cycle

Active Publication Date: 2015-10-21
NAT INST OF METROLOGY CHINA
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Problems solved by technology

The tandem mass spectrometer enhances the analysis efficiency of the ion beam, adds functions such as ion / ion reaction and ion / molecular reaction, and effectively meets the challenges of many applications. However, there are still problems with the tandem mass spectrometer: The mass analysis duty cycle of ions generated by the source is not high and the efficiency is not high when faced with the simultaneous analysis of ions generated by multiple ion sources
Specifically, on the one hand, the existing serial mass analyzers are analyzed in the axial or radial arrangement of the mass analyzers, and share one ion transmission channel, that is, the ions are transmitted from the Nth mass analyzer to the Nth mass analyzer. +2 mass analyzers must pass through the N+1th mass analyzer. Since the analysis time of each mass analyzer is different in practical applications, the mass analyzer in front of the ion channel will inevitably hinder the back of the ion channel. The mass analyzer obtains ions; on the other hand, when the mass analyzer implements multi-level mass spectrometry, the mass analyzer only selects ions with one mass-to-charge ratio for the ions generated by the ion source within a certain period of time. In mass spectrometry, the rest of the ions are discarded during this period, which obviously loses a lot of ion information and reduces the efficiency of analysis; moreover, the newly developed ion / ion reaction, molecule / ion reaction, light / ion reaction, etc. Reaction and other applications require the mass spectrometer to have multiple ion sources, process ions from these ion sources at the same time and perform operations of selecting ions and obtaining product ions respectively, and finally reacting ions from different ion sources before performing mass analysis operations. The current instrument Only time-sharing operations can be performed, and the efficiency is not high enough

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  • Network quality analysis method and apparatus
  • Network quality analysis method and apparatus

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Embodiment 1

[0084] The following is the first embodiment of the present invention, as follows:

[0085] Such as Figure 4 As shown, the A port of the quadrupole ion deflector is connected with the outlet of a quadrupole mass filter; the B port is connected with one of the end cap holes of the 3D (three-dimensional) radio frequency ion trap, and the other end cap hole of the 3D ion trap is connected with the flight time The inlet of the mass analyzer is connected, and the ions in the time-of-flight mass analyzer are detected by the detector 3; the port C is connected with the end cap hole in the 2D (two-dimensional) linear radio frequency ion trap 1, and the ions in the 2D linear radio frequency ion trap 1 can be Radially ejected to the detector 1 for detection, or flow out through the end cap hole through the quadrupole ion deflector into other mass analyzers; the D port is connected to the 2D linear radio frequency ion trap 2, functional and 2D linear radio frequency ion trap 1 is similar. ...

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Abstract

The invention discloses a network quality analysis method and apparatus, relating to the mass spectrometer and ion quality analysis field. The apparatus comprises ion sources used for generating ions to be detected; ion transmitters used for transmitting the ions to be detected; an ion deflector used for controlling the ions to be detected to deflect; and a plurality of quality analyzers used for performing quality analysis on the ions to be detected. The ion transmitters are in connection with one of the quality analyzers; the quality analyzers are all in connection with the ion deflector; the ion sources generate the ions to be detected; the ions to be detected enter any quality analyzer in connection with the ion deflector through the ion transmitters to perform quality analysis; left ions to be detected are transmitted to corresponding quality analyzers through the ion deflector to perform quality analysis. The method and apparatus can increase a continuous type ion source quality analysis duty ratio, and obtain more mass-to-charge ratio information in an ion beam within each time quantum.

Description

Technical field [0001] The invention relates to the field of mass spectrometers and ion mass analysis, in particular to a networked mass analysis method and device. Background technique [0002] Due to the development of related application fields, people need more rapid, highly sensitive, and multifunctional mass spectrometers. The mass spectrometer with a single mass analyzer has been unable to meet many application requirements, so a tandem mass spectrometer with a combination of multiple mass analyzers has been developed to meet these challenges. The tandem mass spectrometer includes a combination of multiple similar mass analyzers, such as ion trap arrays, etc.; it also includes a combination of different types of mass analyzers, such as ion trap-Orbitrap mass spectrometer, quadrupole-time-of-flight mass spectrometer, ion trap -Time of flight mass spectrometer, etc. The tandem mass spectrometer has enhanced the analysis efficiency of the ion beam, increased the functions o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/00H01J49/06G01N27/62
CPCH01J49/009H01J49/061H01J49/0031H01J49/0404H01J49/40
Inventor 江游方向熊行创黄泽建
Owner NAT INST OF METROLOGY CHINA