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A kind of preparation method of polyvinyl alcohol medical sponge

A technology of polyvinyl alcohol and methacrylated polyvinyl alcohol, which is used in medical science, bandages, absorbent pads, etc., can solve problems such as affecting wound healing and human tissue damage, and achieve long curing time and large absorption. , good adhesion effect

Inactive Publication Date: 2017-08-29
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Yet these methods have adopted crosslinking agents such as formaldehyde, hexamethylenetetramine and chemical blowing agents such as amines, hydrazines in the process of preparing polyvinyl alcohol sponge or polyvinyl alcohol composite sponge, these crosslinking agents and The chemical foaming agent itself has considerable toxicity. Even if a small amount remains, it will still cause varying degrees of damage to human tissue and affect the healing of the wound.

Method used

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  • A kind of preparation method of polyvinyl alcohol medical sponge

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preparation example Construction

[0026] A kind of preparation method of polyvinyl alcohol medical sponge, described preparation method is carried out according to the following steps:

[0027] a. Preparation of Methacrylated Polyvinyl Alcohol

[0028] Put polyvinyl alcohol and isocyanoethyl methacrylate in an aprotic solvent, the mass volume ratio of polyvinyl alcohol to aprotic solvent is 1:10-200, the hydroxyl group on the molecular chain of polyvinyl alcohol and the isocyano group of methacrylic acid The isocyano molar ratio of ethyl ester is 1:0.1~10, stir evenly at room temperature, react at 25~80°C, and the reaction time is 12~96 hours. After the reaction, polyvinyl alcohol, methacrylic acid isocyanate Add anhydrous acetone to the mixed solution formed by cyanoethyl ester and aprotic solvent until there is no precipitation in the mixed solution, collect the precipitate, and vacuum dry the precipitate at room temperature for 2 days to obtain methyl Acrylylated polyvinyl alcohol; the aprotic solvent is o...

Embodiment 1

[0047] Weigh 2 g of polyvinyl alcohol (PVA0588) and 0.56 g of isocyanoethyl methacrylate, add them to 20 mL of dimethylformamide, stir well at room temperature, and react at 25°C for 12 hours. After the reaction, Anhydrous acetone was added until no precipitate was precipitated, and the precipitate was collected and vacuum-dried at room temperature for 2 days to obtain methacrylated polyvinyl alcohol with a molar substitution degree of 0.05.

[0048] Weigh 1 g of methacryloyl polyvinyl alcohol with a molar substitution of 0.05, 0.2 g of sodium bicarbonate, 4 g of lactic acid, 0.05 g of 2-hydroxy-2-methyl-1-p-hydroxyethyl ether phenylacetone, 94.75g of deionized water, stirred at room temperature for 10min at high speed, at a wavelength of 320-480 nm and a light intensity of 100 mW / cm 2 Irradiate under ultraviolet light for 1 min to form a methacrylylated polyvinyl alcohol foam sponge, wash with deionized water until neutral, and dry at 60°C for 24 hours to obtain a polyvinyl a...

Embodiment 2

[0050] Weigh 2 g of polyvinyl alcohol (PVA1788) and 55.85 g of isocyanoethyl methacrylate, add them to 400 mL of dimethylacetamide, stir well at room temperature, and react at 80°C for 96 hours. After the reaction, Anhydrous acetone was added until no precipitate was precipitated, and the precipitate was collected and vacuum-dried at room temperature for 2 days to obtain methacrylated polyvinyl alcohol with a molar substitution degree of 0.8.

[0051] Weigh 10 g of methacryloyl polyvinyl alcohol with a molar substitution degree of 0.8, 2 g of potassium bicarbonate, 10 g of malic acid, 0.1 g of 1-hydroxycyclohexyl phenyl ketone, and 77.9 g of deionized water, and stir at room temperature for 10 min at high speed , at a wavelength of 320-480 nm and a light intensity of 5 mW / cm 2 Irradiate under ultraviolet light for 10 min to form a methacrylylated polyvinyl alcohol foam sponge, wash with deionized water until neutral, and dry at 60°C for 24 hours to obtain a polyvinyl alcohol m...

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Abstract

The invention relates to a preparation method of sponge, in particular to a preparation method of polyvinyl alcohol medical sponge, and belongs to the technical field of the preparation of a medical dressing. Polyvinyl alcohol is used as a raw material to prepare the methacrylic acylation polyvinyl alcohol with optical activity groups by means of reaction of hydroxyl groups and isocyano groups, and the methacrylic acylation polyvinyl alcohol is foamed and polymerized by means of ultraviolet rays to obtain the polyvinyl alcohol medical sponge. According to the preparation method, an ultraviolet cross-linking curing technology is used, no cross-linking agent is added, so that the toxicity problem caused by the introduction of aldehydes cross-linking agents and hydrazines foaming agents in a traditional polyvinyl alcohol sponge preparation process can be completely avoided, and the biological compatibility is good. Meanwhile, the prepared polyvinyl alcohol medical sponge is soft in texture, good in adaptability to a wound surface, good in dressing property and capable of being widely applied to drainage wounds such as a burnt wound, an ulcer wound and the like. The preparation method is low in cost, simple in process and suitable for the industrialized production.

Description

technical field [0001] The invention relates to a preparation method of a sponge, in particular to a preparation method of a polyvinyl alcohol medical sponge, belonging to the technical field of preparation of medical dressings. Background technique [0002] Polyvinyl alcohol (PVA) medical sponge, as a degradable porous medical material, has the characteristics of soft texture and high wet strength, especially the remarkable characteristics of absorbing large amount of exudate and absorbing exudate quickly, making it clinically It is widely used in trauma surgery, especially in the field of negative pressure drainage. [0003] Dissolving polyvinyl alcohol and foaming / crosslinking process can make polyvinyl alcohol medical sponge. The Chinese patent publication number is CN103554801A, the publication date is February 5, 2014, the title of the invention is "a modified polyvinyl alcohol sponge and its preparation method", the Chinese patent publication number is CN102078635A, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/24A61L15/42
Inventor 周应山杨硕硕董齐殷先泽杨红军柏自奎顾绍金徐卫林
Owner WUHAN TEXTILE UNIV
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