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Saccharomyces cerevisiae glutathione nutritional preparation

一种营养配制品、酵母营养的技术，应用在含有效成分的医用配制品、三肽成分、食品制备等方向，能够解决增加肝代谢和解毒负担、抗氧化能力下降、组织损伤等问题，达到利于人体利用、排除体内毒素、环境要求低的效果

Inactive Publication Date: 2015-11-18
BEIJING KAWIN TECH SHARE HLDG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In severe diseases such as trauma and sepsis, a large amount of Gln in skeletal muscle is absorbed, and consumption is greater than synthesis, resulting in various symptoms such as relative deficiency of Gln, intestinal mucosal atrophy, translocation of bacteria and endotoxin, and the antioxidant capacity in the body Ability to decline, generate a large number of oxygen free radicals, causing tissue damage, greatly increasing the burden of liver metabolism and detoxification

Method used

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  • Saccharomyces cerevisiae glutathione nutritional preparation
  • Saccharomyces cerevisiae glutathione nutritional preparation
  • Saccharomyces cerevisiae glutathione nutritional preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 is rich in the preparation of the Saccharomyces cerevisiae fermented liquid that is rich in GSH

[0023] Saccharomyces cerevisiae (Saccharomycescerevisiae1251) was purchased from: China Industrial Microbiology Culture Collection Management Center

[0024] Insert strain Saccharomyces cerevisiae into plate culture medium BMGY, culture temperature 26-30°C, after 6-8 days, then move to slant medium BMGY, 26-30°C, 6-8 days to obtain slant spores.

[0025]Use a sterile inoculation loop to dig out 0.5-1cm 2 The slant spores of the first-level seed medium BMGY were cultivated at 26-30°C for 20-30h, and then the first-level seeds were inoculated into the next-level seed medium BMGY, and cultivated at 26-30°C for 20-30h. The inoculation amount of each level of seeds is 10%.

[0026] Insert the last level of seeds into the fermentation medium with an inoculum size of 10%. Medium contains: glucose 25g / l, yeast powder 15g / l, wort 60g / l, ammonium phosphate 10g / l, magn...

Embodiment 2

[0028] Embodiment 2 is rich in the preparation of the Saccharomyces cerevisiae fermented liquid that is rich in GSH

[0029] Saccharomyces cerevisiae (Saccharomycescerevisiae1210) was purchased from: China Industrial Microbiology Culture Collection Management Center

[0030] Medium contains: glucose 25g / l, yeast powder 15g / l, wort 60g / l, ammonium phosphate 10g / l, magnesium sulfate 5g / l, dipotassium hydrogen phosphate 1g / l, potassium dihydrogen phosphate 1g / l, chlorine Calcium 10mg / l, sodium chloride 1mg / l. The culture temperature is 26-28°C, the tank pressure is 0-0.05MPa, the air volume is 1:1-1:2 by volume, the pH is controlled at 6.0 during the fermentation process, glycerin is added after the fermentation starts, and the glycerin concentration is 100g / L. The total glycerol content is 2.0g / 100ml, add inorganic selenium ions, the addition amount is 20mg / L, add 8mmol / l L-cysteine, L-glutamic acid, glycine and 4mmol / l adenosine triphosphate after 1 day of fermentation, Ferme...

Embodiment 3

[0031] Embodiment 3 is rich in the preparation of the Saccharomyces cerevisiae fermented liquid that is rich in GSH

[0032] Saccharomyces cerevisiae (Saccharomycescerevisiae1337) was purchased from: China Industrial Microorganism Culture Collection Management Center. The strains were irradiated with a 10W ultraviolet lamp at 25cm for 3 minutes, turned off the ultraviolet lamp, and placed in the dark for 5 minutes. The obtained mutagen has higher GSH production capacity. Medium contains: glucose 25g / l, yeast powder 15g / l, wort 60g / l, ammonium phosphate 10g / l, magnesium sulfate 5g / l, dipotassium hydrogen phosphate 1g / l, potassium dihydrogen phosphate 1g / l, chlorine Calcium 10mg / l, sodium chloride 1mg / l. The culture temperature is 26-28°C, the tank pressure is 0-0.05MPa, the air volume is 1:1-1:2 by volume, the pH is controlled at 6.0 during the fermentation process, glycerin is added after the fermentation starts, and the glycerin concentration is 100g / L. The total glycerol ...

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Abstract

The invention relates to a nutrition preparation which is rich in nutrition and has an effect of protecting the liver. The nutrition preparation is mainly prepared from GSH-enriched brewer's yeast dried powder, L-Gln and an acceptable excipient in the nutrition preparation. According to the nutrition preparation in the invention, the nutritional ingredients in the yeast are fully utilized, and the nutrition preparation has a better effect of protecting liver injury.

Description

technical field [0001] The present invention relates to a nutrition preparation with rich nutrition and the function of protecting the liver. The nutrition preparation is mainly made of GSH, L-Gln and Saccharomyces cerevisiae dry powder, and the GSH is Saccharomyces cerevisiae rich in GSH , for the field of biological health food. Background technique [0002] Glutathione, namely γ-L-glutamyl-L-cysteinyl-glycine (γ-L-glutamyl-cysteinyl–glycine, referred to as GSH). In 1888, Pailhode first discovered glutathione in yeast extract, which is composed of glutamic acid, cysteine ​​and glycine. [0003] Glutathione is the most abundant small molecule thiol compound in cells. Reduced glutathione is the main component of non-protein sulfhydryl groups in cells. It has a variety of physiological functions of traditional Chinese medicine in living tissues: GSH participates in redox reactions in cells, is a coenzyme of certain enzymes, and activates some sulfhydryl enzymes; provides re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/30A23L1/305A23L31/10A23L33/18
CPCA23L33/00A23V2002/00A61K9/14A61K9/1635A61K9/4866A61K31/198A61K36/064A61K38/06A23V2250/762A23V2250/55A23V2200/30A61K2300/00A23V2200/32A23V2250/31A23V2250/062
Inventor 付大雁
Owner BEIJING KAWIN TECH SHARE HLDG
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