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Natural anti-inflammatory polypeptide cecropin-TY1 extracted from Tabancus yao and application of natural anti-inflammatory polypeptide cecropin-TY1

An anti-inflammatory and natural technology, applied in the field of biomedicine, can solve problems such as aggravating sepsis, and achieve the effects of low cytotoxicity, obvious anti-inflammatory effect, and simple synthesis

Active Publication Date: 2015-11-18
SUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At the same time, there are many shortcomings in these treatment methods. For example, anti-infection treatment will cause a large number of bacteria to be killed and release a large amount of endotoxin, which will aggravate sepsis.

Method used

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  • Natural anti-inflammatory polypeptide cecropin-TY1 extracted from Tabancus yao and application of natural anti-inflammatory polypeptide cecropin-TY1
  • Natural anti-inflammatory polypeptide cecropin-TY1 extracted from Tabancus yao and application of natural anti-inflammatory polypeptide cecropin-TY1
  • Natural anti-inflammatory polypeptide cecropin-TY1 extracted from Tabancus yao and application of natural anti-inflammatory polypeptide cecropin-TY1

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Embodiment Construction

[0021] Below in conjunction with the accompanying drawings and specific examples, the specific implementation of the present invention will be further described in detail. The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0022] 1. The effect of anti-inflammatory polypeptide cecropin-TY1 from Yaofly saliva on the production of nitric oxide (NO) in macrophages induced by lipopolysaccharide (LPS).

[0023] (1), inhibit the transcription of inducible nitric oxide synthase (iNOS):

[0024] Inducible nitric oxide synthase (iNOS) is an essential synthetase for nitric oxide (NO) production. Firstly, the effect of cecropin-TY1 on the transcription level of nitric oxide synthase was detected. C57BL / 6 mouse peritoneal macrophages were plated in 24-well cell culture plates (2.5×10 5 Cells / well), cultivated with RMPI-1640 medium (purchased from Gbico, USA) with 2% fetal bovine serum, 100 U / mL ampicilli...

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Abstract

The invention discloses natural anti-inflammatory polypeptide cecropin-TY1 extracted from salivary glands of Tabancus yao. The natural anti-inflammatory polypeptide cecropin-TY1 comprises 39 amino acids, the carbon tail end is amidated, the molecular weight is 3970.22 Dalton, the isoelectric point is 11.17, the amino acid sequence is SEQ ID: 1, and all the amino acids are L-type. The natural anti-inflammatory polypeptide cecropin-TY1 has the characteristics of small molecular weight, remarkable anti-inflammatory effect and low cytotoxicity, has wide application prospects in anti-inflammatory drugs, drugs for treating septicopyemia and endotoxin shock caused by bacterial infection, veterinary drugs, animal feed and cosmetics and is particularly applied to inhibiting lipopolysaccharide induced macrophages from generating nitric oxide, inhibiting lipopolysaccharide induced macrophages from generating inflammatory cell factors, inhibiting a lipopolysaccharide induced inflammation signal path as well as neutralizeing the endotoxin.

Description

technical field [0001] The invention relates to a natural anti-inflammatory polypeptide cecropin-TY1 extracted from the salivary gland of Yaofly and its new application in anti-inflammation, which belongs to the technical field of biomedicine. Background technique [0002] In recent years, with the abuse of traditional antibiotics, microorganisms have become more and more resistant to traditional antibiotics, and microbial infection has become a problem that seriously threatens human health. These microorganisms, especially Gram-negative bacteria, can release lipopolysaccharide (LPS) during infection, which can cause sepsis and endotoxic shock. The main treatment methods for sepsis caused by microbial infection have been infusion, improving the body's oxygen supply, anti-infection therapy, and immunotherapy. At the same time, there are many shortcomings in these treatment methods. For example, anti-infection treatment will cause a large number of bacteria to be killed and r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/435A61K38/17A61K8/64A61P29/00A61P31/04A01N47/44A01P1/00A23K1/17A23K20/195
CPCA01N47/44A23K20/195A61K8/64A61K38/17C07K14/435C07K14/43563A61K38/00
Inventor 卫林徐薇李敏黄春景
Owner SUZHOU UNIV
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