Composition and application and preparation thereof

Abstract

The invention relates to the field of animal cultivation, in particular to a composition and an application and preparation thereof. The composition comprises cefquinome or a cefquinome salt and an auxiliary material, and the auxiliary material comprises a combination of glidant and one or a mixture (including two or more) of a stabilizer, a suspending agent, synergist, antioxidant and solvent. Safety test results show that milk cows have no adverse reaction to the provided preparation. Local irritation and anaphylaxis test results show that cefquinome sulfate breast injectant (the lactation period) is free of irritant reaction. Curative effect test results show that the tested drug cefquinome sulfate breast injectant has the clearing effect on treating pathogenic bacteria of a milk area, relieves mastitis clinical symptoms of the milk cows, reduces the somatic number of milk, improves the milk quality and has a good treating effect on the clinic mastitis of the milk cows, and the cure rate reaches 80-85%.

Description

technical field [0001] The invention relates to the field of animal breeding, in particular to a composition and its application and preparation. Background technique [0002] Cow mastitis (cowmastitis) is one of the three most common and frequent diseases of dairy cows (mastitis, endometritis, laminitis), which not only seriously affects the milk production, milk quality, reproductive function and service life of dairy cows, but also It is also harmful to food hygiene and human health. Cow mastitis is mainly caused by the invasion of teat ducts, lymphatic vessels or blood vessels by pathogenic bacteria. It is one of the most common diseases threatening the dairy farming industry. At present, about 50% of the dairy cows in the world suffer from various types of mastitis, which seriously affects the healthy development of the dairy industry. [0003] In the United States, 30%-70% of cows have at least one udder area infected. Schutz reported that the annual cost of mastitis...

AI Technical Summary

Problems solved by technology

Therefore, mastitis causes huge losses such as increased treatment costs, reduced milk production, and premature culling of cows.

[0004] In addition, dairy cow mastitis not only causes huge losses due to reduced milk production and affects the quality of dairy products, but also easily turns into chronic mastitis due to untimely or improper treatment, resulting in fibrosis and atrophy of mammary gland tissue, and dairy cows are prematurely eliminated

For the treatment of acute mastitis, antibiotics are generally used, mainly including penicillins, cephalosporins, aminoglycosides, lincosamides and fluoroquinolones. The drug resistance is reduced, the curative effect is reduced, and the residue of antibiotics in milk is increased, which is harmful to human health.

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