Composite electrostatic spinning nanofiber film and preparation method and application thereof

A nanofiber membrane and electrospinning technology, which is applied in the field of medical devices, can solve the problems of abrasion of abdominal organs, easy adhesion of intestinal tubes to the abdominal wall, and organ wear and tear.

Active Publication Date: 2015-12-02
NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

VAC may wear the abdominal organs during use. The US FDA has clearly pointed out that direct contact between VAC and organs may lead to organ wear and intestinal air fistula. , the intestinal tube is easy to adhere to the abdominal wall, so it is impossible to close the abdomen early and delay the recovery time

Method used

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  • Composite electrostatic spinning nanofiber film and preparation method and application thereof
  • Composite electrostatic spinning nanofiber film and preparation method and application thereof
  • Composite electrostatic spinning nanofiber film and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033](1) The water-soluble basic fibroblast factor bFGF was dissolved in physiological saline at 100 ng / ml as the inner water phase W1, the polylactic acid-glycolic acid copolymer PLGA was dissolved in dichloromethane as the oil phase O, and the oil phase The PLGA concentration is 10 mg / mL, and the polyvinyl alcohol PVA aqueous solution with a mass percentage content of 2% is used as the outer water phase W2, and the volume ratio of W1:O:W2 is 15:2:50; The high-speed homogenizer was emulsified at 30,000 r / min for 2 minutes to form colostrum W1 / O. After the colostrum was stable, the colostrum was dropped into the outer water phase W2, and stirred at 15,000 r / min for 3 minutes to form double emulsion W1 / O / W2; then pour the double emulsion into a beaker, volatilize under magnetic stirring for 3 hours at 28°C, filter, centrifuge at 3,500‐5,000r / min for 20 minutes, wash with deionized water, filter and then centrifuge, repeat this operation 3 times until more than The PVA was rem...

Embodiment 2

[0039] 3-6 months old sows weighing about 25kg, fasted for 12 hours before the experiment, could not help water, preoperative administration: intramuscular injection of midazolam 0.5mg / kg, atropine 0.02mg / kg, the animals were fixed on the test bench, and the animals were placed on the test bench. Indwelling venous catheter in the marginal ear vein, then the intravenous pump continued to pump propofol 3mg / kg, endotracheal intubation was followed by a ventilator, ventilator: tidal volume 8mL / kg, inspired oxygen concentration 21%, respiratory rate 20 / min , PEEP5cmH2O, the right femoral artery cannula, monitor arterial pressure, take a median incision, about 15cm long. Cystocentesis was performed to monitor intra-abdominal pressure and urine output. CLP constructs a model of peritoneal sepsis. The right abdominal puncture cannula was used to construct pneumoperitoneum. The abdomen was routinely closed, and the patient was inflated (nitrogen) through the right intubation tube to ...

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Abstract

The invention discloses a composite electrostatic spinning nanofiber film and a preparation method and application thereof. The preparation method of the composite electrostatic spinning nanofiber film carrying drug controlled-release microspheres includes: (1), preparing polylactic acid-glycolic acid copolymer PLGA microspheres with basic fibroblast growth factors (bFGF) embedded; (2), respectively preparing polycaprolactone / chitosan electrostatic spinning liquid, polycaprolactone electrostatic spinning liquid and gelatin electrostatic spinning liquid; (3), using an electrospinning method to prepare a PCL / CS-PLGA microsphere-PCL / GE electrostatic spinning nanofiber film, namely the composite electrostatic spinning nanofiber film. The nanofiber film is utilized to improve bio-compatibility of PU sponge, promote tissue healing and reduce visceral wear; the microspheres are introduced to realize drug controlled-release, and many blanks of clinically-existing VAC can be filled.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to a composite electrospinning nanofiber membrane and a preparation method and application thereof, in particular to a composite electrospinning nanofiber membrane carrying drug controlled-release microspheres and a preparation method and application thereof. Background technique [0002] The experience and lessons of the treatment of war wounds from World War II to the partial wars in Afghanistan and Iraq show that the incidence of abdominal war wounds has not decreased significantly, and it is always the third fatal war wound. Abdominal injury caused by blast injury can lead to different degrees of abdominal wall damage, exposure of abdominal organs, and intestinal prolapse. Intra-abdominal hypertension combined with resuscitation from hemorrhagic shock and traumatic shock can lead to dehiscence of the abdominal incision, resulting in passive opening of the abdominal cavity. Active a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/26A61L15/42A61L15/44D01F8/14D01F8/02D01F8/18
Inventor 任建安吴秀文陈国璞王革非邓友铭黎介寿
Owner NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
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