Chinese herba preparation, medicament box and application thereof

A traditional Chinese medicine preparation and preparation technology, applied in the direction of non-central analgesics, antipyretics, anti-inflammatory agents, etc., can solve the problems of easy degradation, poor effect, transportation, storage, and inconvenient use, and achieve stability, The effect of enhancing the therapeutic effect

Active Publication Date: 2015-12-23
LUOYANG RUIHUA ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the Shuanghuanglian soluble powder prepared by this preparation process has the disadvantage that the active ingredients are easily degraded in partial water, and the Shuanghuanglian oral liquid has the problems of inconvenient transportation, storage and use.
[0006] The Ministry of Agriculture Announcement No. 1433 disclo

Method used

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  • Chinese herba preparation, medicament box and application thereof
  • Chinese herba preparation, medicament box and application thereof
  • Chinese herba preparation, medicament box and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]Embodiment 1, get 750g of honeysuckle, 750g of Scutellaria baicalensis, 1500g of forsythia, decoct honeysuckle with 8 times the amount of water for 1 hour and 45 minutes, concentrate the decoction to a density of 1.05, cool to 50 degrees, add 20% milk of lime, make the pH reach 12, filter the precipitate and add 2 times the amount of 95% ethanol, put it through a 60-mesh sieve, adjust the pH to 3.5 with 50% sulfuric acid, stir well, filter, and neutralize the filtrate to 7.0 with 40% sodium hydroxide solution. After filtering, the filtrate is made into a microcapsule coating with β-cyclodextrin in a fluidized bed, and the water content is controlled below 4.0%, and it is set aside. Add 8 times the amount of water to Scutellaria baicalensis, decoct for 4 hours, concentrate the decoction to a density of 1.02, adjust the pH to 2.0 with hydrochloric acid, keep it warm at 80 degrees, let it stand, filter, add water to the precipitate, stir well, and use 40% sodium hydroxide so...

example 2

[0029] Example 2. Take 750g of honeysuckle, 750g of Scutellaria baicalensis, and 1500g of forsythia, add 8 times the amount of water to decoct the honeysuckle for 1 hour and 45 minutes, concentrate the decoction to a density of 1.05, cool to 50 degrees, add 20% lime milk, and make the pH reach 12. Add 2 times the amount of 95% ethanol to filter the precipitate, put it through a 60-mesh sieve, adjust the pH to 3.5 with 50% sulfuric acid, stir well, filter, and neutralize the filtrate to 7.0 with 40% sodium hydroxide solution, filter After that, the filtrate is made into a microcapsule coating with β-cyclodextrin in a fluidized bed, and the water content is controlled below 4.0%, and it is set aside. Add 8 times the amount of water to Scutellaria baicalensis, decoct for 4 hours, concentrate the decoction to a density of 1.02, adjust the pH to 2.0 with hydrochloric acid, keep it warm at 80 degrees, let it stand, filter, add water to the precipitate, stir well, and use 40% sodium h...

Embodiment 2

[0030] Embodiment 2, the inventive method compare with other preparation methods

[0031] Sample 1, the sample prepared in Preparation Example 1.

[0032] Sample 2: the sample prepared in Preparation Example 2.

[0033] Sample 3: Take 750g of honeysuckle, 750g of Scutellaria baicalensis, and 1500g of forsythia, decoct the honeysuckle with 8 times the amount of water for 1 hour and 45 minutes, concentrate the decoction to a density of 1.05, cool to 45-60 degrees, add 20% lime milk, and make When the pH reaches 12-13, add 2 times the amount of 95% ethanol to the filtered precipitate, put it through a 60-mesh sieve, adjust the pH to 3-4 with 50% sulfuric acid, stir well, filter, and put the filtrate in 40% sodium hydroxide solution and pH to 6.5-7.0, filtered, and the filtrate is made into a microcapsule coating with β-cyclodextrin in a fluidized bed, and the water content is controlled below 4.0%, and it is set aside. Add 8 times the amount of water to Scutellaria baicalensis,...

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Abstract

The invention provides a Chinese herba preparation. The Chinese herba preparation comprises a micro-capsule incrusting matter for a Shuanghuanglian powder and an acidic auxiliary material, and the acidic auxiliary material accounts for 10 percent of the total weight of the preparation. The Chinese herba preparation provided by the invention not only can solve the problems in the stability of the preparation in alkaline water, but also can ensure effective dissolution of the active components of the preparation. When the Chinese herba preparation and carbaspirin calcium form a compound preparation, the curative effect on the aspect of cooling down can also be enhanced, and a method which is more economic and effective on livestock fever symptoms in clinic by compared with using the preparation and the carbaspirin calcium independently is provided. The invention further provides a medicament box. The medicament box comprises a Shuanghuanglian oral liquid part and a carbaspirin calcium part, and the carbaspirin calcium part further comprises acidic auxiliary materials.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and in particular relates to a traditional Chinese medicine preparation and a medicine box of Shuanghuanglian preparation. Background technique [0002] Shuanghuanglian preparation is made of 3 traditional Chinese medicines of scutellaria baicalensis, honeysuckle, and forsythia through a series of processes such as extraction, concentration, and filtration to make clinically required dosage forms. It is mainly used in veterinary clinics for fever, loss of appetite, Cough embolism. At present, there are two kinds of Shuanghuanglian series preparations used in animal clinics in the market: Shuanghuanglian oral liquid and Shuanghuanglian soluble powder. The Shuanghuanglian preparation produced according to the Veterinary Pharmacopoeia has poor stability, and the active ingredient (baicalin) is easily degraded in an alkaline aqueous solution. However, the water in North China is basically alkaline...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61K47/48A61K47/12A61P29/00A61K31/616A61K47/69
Inventor 李新李阳沈东林
Owner LUOYANG RUIHUA ANIMAL HEALTH PROD
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