Contiguous overlapping peptides for treatment of house dust mites allergy

A technology of overlapping peptides and dust mites, applied in the direction of allergic diseases, peptides, peptide sources, etc., can solve the problems of reducing the re-formation of allergens and reducing the ability

Inactive Publication Date: 2016-02-03
ANERGIS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These selected fragments exhibit a reduced ability to reform the original tertiary structure of the allergen, if any, resulting in a reduced ability to bind IgE and thus elicit an allergic response in humans

Method used

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  • Contiguous overlapping peptides for treatment of house dust mites allergy
  • Contiguous overlapping peptides for treatment of house dust mites allergy
  • Contiguous overlapping peptides for treatment of house dust mites allergy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0078] The present invention is described hereinafter by way of example with reference to the following experimental procedures and results.

[0079] Materials and methods

[0080] allergen

[0081] Purified native Derp1 (NA-DP1-2) and native Derp2 (NA-DP2-2) were obtained from Indoor Biotechnologies Ltd, UK, UK.

[0082] Peptide selection and synthesis

[0083] The purpose is to prevent the formation of stable tertiary structure of B-cell epitopes, and present below the SEQ ID NO: 27 (Derp1) Swiss-Prot sequence P08176.2 and SEQ ID NO: 28 (Derp2) gene bank sequence AFJ68067.1 shown below All T cell epitopes present within the Derp1 and Derp2 protein sequences are presented. It should be noted that Derp2 exists in the form of multiple isoforms with SwissProtP49278.1 (SEQ ID NO: 29) described in the previous patent application WO2004-081028 (A2), the disclosure of which Incorporated herein by reference. There are four amino acid differences between the GenBank sequence AFJ6...

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Abstract

Contiguous overlapping peptides (COPs) for the treatment of allergic patients by Specific Immunotherapy (SIT) are provided from the sequence of the major allergens of house dust mites Der p 1 and Der p 2. Such peptides while providing all potential T cell epitopes are devoid of the three dimensional structure of the original allergen, therefore reducing their ability to bind IgE. As a result increased amounts of COPs can be administered per injection, therefore reducing both the number of injections and the length of the immunotherapy treatment.

Description

[0001] Cross References to Related Applications [0002] This application is based on US Provisional Application Serial No. 61 / 831,961 filed June 6, 2013, the disclosure of which is incorporated herein by reference in its entirety. [0003] Incorporation by reference of electronically submitted material [0004] Incorporated by reference in its entirety is the computer-readable Amino Acid Sequence Listing, also filed herein and identified as follows: ASCII text file, named filename: 47712A_SeqListing.txt; Size: 20,103 bytes; Created: 2014 June 5th. technical field [0005] The present invention relates to continuous overlapping peptides (COPs) derived from the major allergens of Derp1 and Derp2 house dust mite and the use of these compounds in medicine. The compounds and methods of treatment of the present invention are expected to be useful in the treatment of and generally facilitate the treatment of house dust mite allergy. Background technique [0006] IgE-mediated al...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/36C07K14/415A61K39/35C07K14/435A61K39/02A61K39/00
CPCA61K39/35A61K2039/55505A61K2039/70C07K2319/00A61K2039/55566C07K14/43531A61P37/08
Inventor 亚历山大·谢特纳克里斯托弗·雷蒙
Owner ANERGIS
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